Viscosity-Tuned Mitochondrial Probe for Precision Tumor Theranostics and Apoptosis Imaging [0.03%]
黏度调节的线粒体探针用于肿瘤精确诊断治疗及凋亡成像
Jialu Tian,Lixia Zhang,Yanchun Qiao et al.
Jialu Tian et al.
Early cancer diagnosis greatly enhances survival rates and improves patients' quality of life. Intracellular viscosity, among various microenvironmental factors influencing cellular function, plays a pivotal role. Abnormal viscosity levels ...
Combining the NanaPPI Toolbox and AI-Driven Virtual Inhibitor Screening for the p53-MDM2 Interaction [0.03%]
结合NanaPPI工具箱和人工智能驱动的虚拟抑制剂筛选用于p53-MDM2相互作用
Huijuan Liu,Hong Zhang,Saiyang Ding et al.
Huijuan Liu et al.
High-throughput screening for inhibitors of protein-protein interactions (PPIs) provides vital information for therapeutic intervention in diseases driven by aberrant PPIs. Traditionally, the discovery of PPI inhibitors involves sequential ...
Prussian Blue Nanozyme-Based Dry-Dipstick Reflectometry for Multiplex Detection of Low Molecular Weight Metabolites [0.03%]
基于普鲁士蓝纳米酶的干试纸反射法用于低分子量代谢物的多重检测
Tangwen Wang,Kelan Yan,Lu Ding et al.
Tangwen Wang et al.
Chronic diseases (CDs) and their associated hepatic and renal dysfunctions pose grim global health challenges, severely compromising quality of life while increasing morbidity and mortality rates. In China, a big bottleneck in effective CD ...
Integrated Single-Cell Proteomic and Morphometric Analysis Reveals Heterogeneous Drug-Resistant Subpopulations [0.03%]
整合单细胞蛋白质组和形态学分析揭示异质性耐药亚群
Qian-Xi Fan,Yi-Rong Jiang,Jian-Bo Chen et al.
Qian-Xi Fan et al.
Investigating the heterogeneous responses of individual cancer cells to chemotherapeutic drugs is crucial for deciphering the mechanisms of cancer drug resistance. In recent years, single-cell proteomics has demonstrated its significant cap...
Multilayer Counterflow Microdialysis Chips for Scalable Buffer Exchange and Sample Purification [0.03%]
用于规模化缓冲液交换和样品纯化的多层逆流微透析芯片
Sima Mehraji,Don L DeVoe
Sima Mehraji
In this study, we present a scalable multilayer platform enabling rapid buffer exchange and sample purification by counterflow microdialysis. The microfluidic system features a compact design employing polycarbonate substrates that contain ...
Discrimination of Dengue Diseases in Children Using Surface-Enhanced Raman Spectroscopy Coupled with Machine Learning Approaches [0.03%]
基于表面增强拉曼光谱结合机器学习区分登革热儿童患者类型研究
Uraiwan Waiwijit,Pitak Eiamchai,Saksorn Limwichean et al.
Uraiwan Waiwijit et al.
This study introduces a novel approach to dengue diagnostics by leveraging surface-enhanced Raman spectroscopy (SERS) coupled to machine learning. This method addresses the critical need for rapid and accurate identification of dengue virus...
Kenneth R Durbin,Matthew T Robey,Joseph B Greer et al.
Kenneth R Durbin et al.
Charge state deconvolution is essential for efficient and effective protein mass spectrometry analysis. High-quality mass profiling is necessary to determine which proteoforms are present in protein samples and their relative abundances. In...
MOF-Integrated Single-Enzymatic Colorimetric Paper-Based Biosensor for Point-of-Care Testing of Organophosphorus Pesticides [0.03%]
基于金属有机骨架的单酶试纸型生物传感器用于现场检测有机磷农药
Jiaqi Huang,Yanfei Zhang,Huiwen Wang et al.
Jiaqi Huang et al.
Organophosphorus pesticides (OPs), which are widely applied in agriculture, raise significant environmental and health concerns due to their neurotoxic inhibition of acetylcholinesterase (AChE). Conventional point-of-care testing (POCT) met...
Simultaneous Bioelectrochemical Detection of Nitrate and Nitrite with a Whole-Cell Hydrogel Electrode [0.03%]
具有整体细胞水凝胶电极的同时生物电化学检测硝酸盐和亚硝酸盐的方法
Qichao Fan,Yang Chen,Rui-Jie Ma et al.
Qichao Fan et al.
Bioelectrochemical sensors (BES) are promising to specifically detect nitrate or nitrite but never realize simultaneous detection in a single system. In this study, a novel biosensor using self-assembled hydrogel bioelectrodes with reduced ...
Quantification Challenges in Polymer Analysis in Urban Runoff and Wastewater using Pressurized Liquid Extraction and Double-Shot Pyrolysis-Gas Chromatography-Mass Spectrometry [0.03%]
城市地表径流和污水中聚合物分析的量化挑战：采用加压液体萃取及双射流水解-气相色谱-质谱法
Daniele Martuscelli,Jonas B Jensen,Luca Solari et al.
Daniele Martuscelli et al.
Microplastics are persistent environmental pollutants with potential risks to ecosystems and human health. This study optimized methods for isolating and quantifying polyethylene (PE), polyethylene terephthalate (PET), polypropylene (PP), a...