Three-Metal Oxide Hollow Lamellar Cube and Oxygen Vacancy Engineering: Construction of a Dual-Mode Sensing Platform and Collaborative Detection Mechanism [0.03%]
三金属氧化物中空棱柱状立方体与氧空位工程：构建双模式传感平台和协同检测机制研究
Haiyang Wang,Di Wu,Shuqun Lao et al.
Haiyang Wang et al.
With increasing public awareness of healthcare, the demand for early screening of cancer biomarkers has grown substantially. Nanozymes, with their unique catalytic and sensing properties, have emerged as promising alternatives in this field...
Ultra-Sensitive Multi-Gas Detection (CS2/SO2/H2S/OCS) Using Spectral Reconstruction Combined with Differential Temperature Conversion [0.03%]
基于光谱重建和差分温度转换的高灵敏多气体（CS₂/SO₂/H₂S/OCS）检测方法研究
Yongqi Wu,Fu Wan,Mu Li et al.
Yongqi Wu et al.
This study presents a detection system for the simultaneous quantification of SF6 decomposition products (CS2, SO2, H2S, and OCS) at ppb/ppm-level precision. To address the challenges of overlapping UV absorption spectra between CS2 and SO2...
Dual-Probe Strategy-Enabled Multiplex Photoelectrochemical Sensor for Highly Sensitive Screening of Diabetes and Related Complications [0.03%]
一种双探针策略驱动的光电化学传感器用于糖尿病及其并发症的高灵敏筛查
Wen Li,Wenhong Yang,Mingwang Liu et al.
Wen Li et al.
Photoelectrochemical (PEC) biosensing has emerged as a vital tool in disease surveillance and therapeutic monitoring. However, most current PEC platforms are constrained to single biomarker detection, limiting their utility in comprehensive...
Yellow Fluorescent Hydrogel with Carbon Quantum Dots: An Innovative Guardian in the Field of Information Security [0.03%]
一种新型的信息安全防护材料：碳量子点黄色荧光水凝胶
Guiting Lin,Zihan Zhao,Zhangmeng Liu et al.
Guiting Lin et al.
In the digital information era, the demand for advanced cryptographic protocols and anticounterfeiting technologies is increasingly intensifying. Leveraging their intrinsic stimuli-responsible characteristics, hydrogels have ascended as pre...
A Novel Hybrid LC-MS/MS Methodology for the Quantitative Bioanalysis of Antibody-siRNA Conjugates [0.03%]
一种抗体siRNA缀合物定量生物分析的新颖混合LC-MS/MS方法学
Zifeng Song,Long Yuan
Zifeng Song
Small interfering RNA (siRNA) is a new class of oligonucleotide therapeutics that is rapidly growing in drug research and development for the treatment of various diseases. One major challenge for siRNA therapeutics is their inefficient del...
Bipartite Genetically Encoded Biosensors to Sense Calcium Ion Dynamics at Membrane-Membrane Contact Sites [0.03%]
双相基因编码生物传感器 检测膜-膜接触位点的钙离子动态变化
Issei Yamaguchi,Lucia Barazzuol,Giulia Dematteis et al.
Issei Yamaguchi et al.
Self-complementing bipartite fluorescent proteins (FPs) are useful tools for the detection of protein-protein proximity and for localizing fluorophores to membrane-membrane contact sites. Here, we report versions of circularly permuted gree...
Dual Organelle-Targeted Near-Infrared Fluorescent Probe for Exploring Dynamic Nuclear Changes during Photodynamic Therapy [0.03%]
双定位 organelle-靶向的近红外荧光探针用于探索光动力治疗过程中动态核变化
Pengju Sun,Yuanyuan Li,Qiuya Wang et al.
Pengju Sun et al.
Observing the dynamic changes of important organelles during photodynamic therapy (PDT) can more intuitively elucidate the mechanism of action, but organelle-targeted fluorescent probes capable of accomplishing this task face challenges. He...
A Robust Immobilization Method for Membrane Protein SPR Assays Using SpyCatcher-SpyTag [0.03%]
一种用于膜蛋白SPR检测的SpyCatcher-SpyTag固定方法
Li Yan,Chenchen Zhu,Yingkui Dong et al.
Li Yan et al.
Membrane proteins are essential for numerous biological processes and constitute a significant portion of drug targets, making the study of their interactions with ligands crucial for drug discovery. Surface plasmon resonance (SPR) is a pow...
Zeyu Zhu,Chengyi Xie,Shaojie Lin et al.
Zeyu Zhu et al.
Collision cross section (CCS) is a crucial parameter in ion mobility-mass spectrometry, which plays a significant role in enhancing the precision of compound annotation. Computational prediction methods aim to infer the CCS value from molec...
Microdroplet Mass Spectrometry Enables Rapid and Sensitive Measurement of Glucose Homeostasis for Elucidating Mechanism of Drug Action [0.03%]
微滴质谱技术可快速灵敏测定葡萄糖稳态阐明药物作用机制
Huifang Yao,Dan Zhou,Sophie VanSickle et al.
Huifang Yao et al.
Microdroplet chemistry has recently gained much attention, as reactions can be greatly accelerated in microdroplets. This study reports its first application in pharmaceutical bioanalysis settings to measure glucose homeostasis with unprece...