Benchmark for Quantitative Global and Redox Proteomics Analysis by Combining Protein-Aggregation Capture and Data Independent Acquisition [0.03%]
结合蛋白质聚集捕获和数据独立采集的定量全球及氧化蛋白质组分析标准品
Ana Martinez-Val,Samuel Lozano-Juárez,Jorge Lumbreras Burgueño et al.
Ana Martinez-Val et al.
Oxidative damage plays a critical role in various diseases including cardiovascular and neurological disorders. Thiol redox reactions, acting as oxidative stress sensors, influence protein structure and function. Redox proteomics, based on ...
Identifying the Oxidase-like Behavior of N-Doped Carbon Nanozymes via Postsynthetic Modification for Colorimetric Sensing [0.03%]
通过 post-synthesis修饰识别N掺杂碳纳米酶的类氧化酶行为用于比色传感
Chengcheng Gu,Dejie Ma,Liuhan Zhang et al.
Chengcheng Gu et al.
N-doped carbon nanomaterials (NCMs) have attracted significant interest as metal-free nanozymes for sensing due to their exceptional stability and biocompatibility. However, the controversial active sites and catalytic pathways severely hin...
Harnessing Energy Enrichment Strategy for Designing Innovative Sandwich-Structured Upconversion Nanoprobes [0.03%]
用于设计创新夹心结构上转换纳米探针的能量增强策略的研究
Jiawei Zhu,Xiaohui Kang,Jianjun Shen et al.
Jiawei Zhu et al.
Despite the various advantages of upconversion nanoparticles (UCNPs), the paradoxes of high luminescence resonance energy transfer (LRET) efficiency and low quantum yield remain a bottleneck for broader sensing applications. Herein, novel s...
Ion Luminescent Micelles: A Surfactant-Mediated Double-End Signal Amplification Strategy for Portable Detection of Phoxim [0.03%]
离子发光胶束：一种双端信号放大策略的表面活性剂介导便携式检测涕灭威的方法
Siying Che,Gaoqiong Deng,Yaoyu Qi et al.
Siying Che et al.
Residues of organophosphorus pesticides (OPs) raise considerable concern, while achieving high enough detection sensitivity is still a challenge for on-site fluorescence techniques. Herein, we report a "double-end samplification" strategy b...
Endogenous Enzyme Stimulation of Localized Catalytic DNA Assembly for High-Contrast microRNA Imaging and Reliable Evaluation of Drug Resistance [0.03%]
内源酶刺激的局部催化DNA装配用于高对比度microRNA成像及可靠的耐药性评估
Yuqian Jiang,Chenxia Xie,Yingying Chen et al.
Yuqian Jiang et al.
Localized DNA circuits have emerged as a powerful platform for real-time visualization of disease-associated biomolecules in living cells, enabling deeper insights into complex biological processes. However, their extensive applications hav...
Single-Electrode High-Throughput Dual-Color Electrochemiluminescence Array Biosensor: Portable Parallel Screening of Marine Pathogens [0.03%]
一次性电化学发光双色阵列免疫传感器的便携式高通量筛选模式
Yuting Du,Yuanzhen Ning,Wenya Zhang et al.
Yuting Du et al.
To achieve high-throughput rapid monitoring of marine pathogens, this study developed an innovative single-electrode electrochemiluminescence (SEE) array biosensing imaging platform. For the first time, the highly luminous RuSiO2-Au and Lu@...
High-Affinity Aptamer Selection for Microbial Transglutaminase and Application in Colorimetric-SERS Dual-Mode Detection [0.03%]
用于微生物转谷氨酰胺酶的高亲和力适配体筛选及比色表面增强拉曼双模式检测中的应用
Xiaoyao Wang,Qinyan Xu,Zepeng Gu et al.
Xiaoyao Wang et al.
Microbial transglutaminase (MTGase) from Streptomyces mobaraensis is widely used in food processing to improve texture but poses health risks due to immune reactions and masking raw material quality. This study developed a sensitive detecti...
Two-Dimensional Dissipative Paper-Based Immunoassay with Oxygen Vacancy-Enriched CeO2 Nanozymes for Portable Cancer Screening [0.03%]
基于氧空位富集的CeO2纳米酶的二维耗散纸基免疫分析便携式癌症筛查法
Zhichao Yu,Man Xu,Di Wu et al.
Zhichao Yu et al.
Rapid, low-cost, and efficient cancer screening in developing regions is urgently needed. In this work, we proposed a peroxidase-like reaction system centered on endogenous Ce coordination differences by exploring the surface oxygen overflo...
Metabolite Fusion between Breath and Blood Enables More In-Depth Understanding of the Endogenous Metabolome [0.03%]
呼出气体代谢物与血液代谢物的融合使人们能够更深入地了解内源性代谢组
Zhifeng Tang,Jianming Yang,Bingtian Su et al.
Zhifeng Tang et al.
Blood is a widely used sample type in metabolomics but often loses volatile compounds during analysis. In contrast, exhaled breath offers a noninvasive and complementary matrix that retains these volatiles. However, the accuracy of metaboli...
Multifunctional Gold Nanoclusters for a Lung Tissue Distribution Study of a Novel Anti-asthma Inhaled Antibody [0.03%]
用于新型抗哮喘吸入型单克隆抗体肺部分布研究的金纳米团簇及其多种功能性能研究
Yingying Xu,Liu Yang,Ting Zhao et al.
Yingying Xu et al.
Pulmonary delivery of monoclonal antibodies has revolutionized the treatment of various types of lung diseases, such as severe asthma. However, the inconsistent antibody drug concentrations in the lungs and serum highlight the importance of...