Multi-Module Cassette Tangential Flow Filtration Enables High-Throughput Isolation and Functional Analysis of Small Extracellular Vesicle Subpopulations [0.03%]
多模块 cassette 平行流过滤能够实现小细胞外囊泡亚群的高通量分离及功能分析
Xisuo Su,Xiaoqin Hong,Jiantong Dong et al.
Xisuo Su et al.
Small extracellular vesicles (sEVs) are nanoscale, lipid bilayer-enclosed vesicles that carry diverse biomolecules and hold considerable potential in disease diagnosis, monitoring, and therapeutic interventions. Efficient and scalable isola...
Homogeneous Hot Spots Plasmonic Microcapsules Integrated Enrichment-Detection All-in-One for Sensitive and Repeatable Surface-Enhanced Raman Spectroscopy Analysis [0.03%]
均一等离子体微胶囊集成富集检测装置用于灵敏且可重复的表面增强拉曼光谱分析
Dan Li,Ling Xia,Gongke Li
Dan Li
Rapid and accurate analysis of complex samples by surface-enhanced Raman spectroscopy (SERS) still faces challenges. Herein, an enrichment-detection all-in-one strategy within plasmonic microcapsules (PMCs) was proposed for sensitive and re...
A Monolith-Based μHPLC-SERS Integrated Microplatform Featuring Mg2+-Regulated Dual-Capture Mechanism for Real-Time Online ATP Monitoring [0.03%]
一种基于整体的μHPLC-SERS集成微平台实时在线监测ATP的方法
Qian Xie,Shulun Xie,Liuhong Lin et al.
Qian Xie et al.
Adenosine triphosphate (ATP), a universal energy currency and biomarker of cellular viability, undergoes dynamic fluctuations critical for neurological health, food safety, and clinical diagnostics. Real-time monitoring of ATP in cerebrospi...
Integrating AF4 and Py-GC-MS for Combined Size-Resolved Polymer-Compositional Analysis of Nanoplastics with Application to Wastewater [0.03%]
结合AF4和Py-GC-MS进行纳米塑料尺寸解析聚合物组分分析及其在污水处理中的应用
Maria Hayder,Cloé Veclin,Aislinn Ahern et al.
Maria Hayder et al.
Although nanoplastics are a widespread pollutant, their characterization and quantification in environmental samples remains challenging with no standard approach currently available. Here, we describe a novel workflow for nanoplastic analy...
Correction to "DNA Origami Plasmonic Nanoantenna for Programmable Biosensing of Multiple Cytokines in Cancer Immunotherapy" [0.03%]
“癌症免疫治疗中用于多种细胞因子程序化生物传感的DNA折纸等离激元纳米天线”的纠正意见
Jie Tang,Chen Ji,Xing Lu et al.
Jie Tang et al.
Published Erratum
Analytical chemistry. 2025 Jul 11. DOI:10.1021/acs.analchem.5c03711 2025
Novel Urazole-Derived MS-Cleavable Cross-Linkers Targeting Tyrosine/Lysine Residues for Protein Structural Analysis [0.03%]
一类新型尿唑衍生物的MS裂解交联剂用于酪氨酸/赖氨酸残基靶向及蛋白质结构分析
Yanxin Zhang,Qibo Yan,Ming Li et al.
Yanxin Zhang et al.
Chemical cross-linking mass spectrometry (XL-MS) is crucial for probing protein structure and protein-protein interactions. Currently, lysine-reactive cross-linkers have been widely developed and applied. In this study, two urazole-derived ...
Sensitive Detection of Exosomal Biomarkers via a Drop-Shaped Porous Microfluidic Chip for Potential Diagnosis of Alzheimer's Disease [0.03%]
基于滴形多孔微流控芯片的外泌体生物标志物灵敏检测用于阿尔茨海默病的潜在诊断
Huiying Xu,Yujing Zhang,Lihua Shen et al.
Huiying Xu et al.
Alzheimer's disease (AD), a progressive and irreversible neurodegenerative disorder, underscores the critical need for developing noninvasive early diagnostic methods. In recent years, blood-exosome-based diagnostics have emerged as a promi...
Rapid Fluorescence Lifetime Imaging through One-Dimensional Deep Learning Optimization [0.03%]
基于一维深度学习优化的快速荧光寿命成像技术
Xinwei Gao,Yanfeng Liu,Yong Guo et al.
Xinwei Gao et al.
Traditional fluorescence lifetime imaging (FLIM) provides valuable quantitative insights for biomedical and molecular biology research, but often relies on computationally intensive datafitting methods to extract meaningful metrics. To addr...
Yuhang Yang,Zechun Li,Ruomeng Guo et al.
Yuhang Yang et al.
Simultaneous thermal analysis (STA) is a well-established characterization method that quantitatively measures changes in sample weight and endothermic/exothermic properties. Currently, commercial STA instruments have reached their maximum ...
Li Zhang,Guoming Xie,Min Qing
Li Zhang
The inherent programmability of DNA, dictated by Watson-Crick base-pairing and sequence diversity, renders it a versatile biomolecule for nanoscale engineering. Toehold-mediated strand displacement (TMSD) enhances DNA strand exchange by ove...