Pyrolysis Compound-Specific Isotope Analysis of Proteins in Aged Paintings: Diketopiperazine δ13C Values as Collagen Source Indicators [0.03%]
老化绘画中蛋白质的裂解化合物特异性同位素分析：二酮基肽胺δ13C值作为胶原蛋白来源指示物的研究
Eugenia Geddes da Filicaia,David A Peggie,Iain P Kendall et al.
Eugenia Geddes da Filicaia et al.
Proteins have been used as adhesives in art throughout history, but determining their source in aged paintings is challenging. Moreover, the distinction between terrestrial and aquatic animal glues is only achievable with proteomic approach...
Akila Wijesinghe,Ridhanya Sree Balamurugan,Umamaheswara Rao Tida et al.
Akila Wijesinghe et al.
Nucleic acid microarrays are widely used in many biological and medical applications. One of the critical steps in the nucleic acid microarray is the placement of nucleic acid molecules using molecular printing in designated spots on the su...
In Situ SERS Monitoring of Membrane Protein Homo- and Hetero-Dimerizations at the Single-Cell Level [0.03%]
单细胞水平上膜蛋白同源和异源二聚化的原位SERS监测
Chen Dong,Xinyue Fang,Tingxiao Wang et al.
Chen Dong et al.
Dimerization of cell membrane receptors governs essential cellular processes─including signal transduction, growth, proliferation, and apoptosis─yet precise discrimination between homo- and heterodimers remains a persistent technical chal...
An Activatable Ratiometric Photoacoustic/Near-Infrared-II Fluorescence Dual-Modal Probe for in vivo Imaging of pH [0.03%]
一种激活型比率型光声/近红外二区荧光双模态探针用于活体成像检测pH值
Jiahao Zhao,Di Liu,Qiang Tong et al.
Jiahao Zhao et al.
Tumor acidity is a key driver of cancer progression and a promising target for early diagnosis and therapy. However, existing approaches remain limited in their ability to sensitively and specifically visualize and quantify tumor acidity in...
Orthogonal Aptamer-Lectin Co-Recognition Enables Sandwich-Type Assays for Glycoproteins [0.03%]
正交型适配体-凝集素协同识别介导糖蛋白的夹心型检测
Dinghui Xiong,Yunyan Ren,Jimmy Gu et al.
Dinghui Xiong et al.
Sandwich assays are widely used for protein detection, but aptamer-based formats are constrained by the difficulty of identifying two high-affinity aptamers that bind distinct, nonoverlapping epitopes on the target. Here, we present an orth...
A pH-Calibrated Multi-Analyte MXene Aerogel Electrochemical Platform Assisted by Interpretable Machine Learning for CSF-Based Prescreening of Postoperative Bacterial Meningitis [0.03%]
基于解释性机器学习的pH校准多分析MXene气凝胶电化学生物传感器用于脑脊液基术后细菌性脑膜炎预筛查
Yuxian Chen,Haoyu Xiao,Qiuyi Deng et al.
Yuxian Chen et al.
Rapid and reliable prescreening and early risk stratification of postoperative meningitis (PNM) remain challenging because clinical symptoms are nonspecific and culture-based testing is time-consuming. Here, we report a machine-learning-ass...
Enhanced Fluorescent Aptasensor Via Tetrahedral DNA Framework-Mediated Multivalent Aptamer Network and High-Quantum-Yield Carbon Quantum Dots [0.03%]
基于四面体DNA框架的多重适配子网络和高量子产率碳点的荧光适配子传感器增强技术
Luyu Wei,Mingrui Xu,Yinjiao Shi et al.
Luyu Wei et al.
Fluorescent aptasensors are promising molecular diagnostic platforms due to their high specificity, stability, and rapid response; however, their sensitivity for trace-level detection is often limited by the low recognition efficiency of ap...
Machine Learning-Driven Biomimetic MXene-Based Sensor Array for Ultraefficient Multiplexed Oxyanions Detection [0.03%]
一种机器学习驱动的仿生MXene基传感器阵列用于高效 oxyanion 检测
Jiaxin Xiao,Guoci Lu,Haoran Yuan et al.
Jiaxin Xiao et al.
The pervasive contamination of groundwater by highly toxic oxyanions necessitates advanced sensing technologies capable of high-throughput screening. To overcome the intrinsic single-analyte limitation of conventional ion-selective electrod...
Avidin-Functionalized Gold Nanoparticles Enable Cationic Isotachophoresis for Enhanced Lateral Flow Assays [0.03%]
带有过量生物素功能化的金纳米粒子增强型等电聚焦免疫层析试纸条
Devon McCornack,Cornelius F Ivory,Zhihong Zhang et al.
Devon McCornack et al.
Lateral flow assays (LFAs) are widely used for rapid, point-of-care diagnostics but struggle with sensitivity in part due to passive migration and interference from high-abundance serum proteins. Here, we introduce the lateral isotachophore...
Controlled Debundling of Single-Walled Carbon Nanotubes (SWCNTs) by Au@Pt Nanorods Enables Mechanism-Dependent Electrochemical Sensing and Biofouling Response [0.03%]
Au@Pt纳米棒控制单壁碳纳米管（SWCNT）解组装实现基于机制的电化学生物传感及生物污染响应
Bahar Mostafiz,Emil Rosqvist,Ermei Mäkilä et al.
Bahar Mostafiz et al.
Single-walled carbon nanotubes (SWCNTs) form intrinsically bundled networks due to strong intertube interactions, yet conventional debundling approaches can disrupt or chemically alter the nanotube structure. Here, Au@Pt nanorods (NRs) were...