Achieving High Potential Stability of Solid-Contact Ion-Selective Electrodes: The Role of Solution with the Primary Ion Preconditioning of the Membrane Cocktail [0.03%]
高稳定性固接离子选择电极的制备及其预处理对膜内主离子浓度影响的研究
Canwei Mao,Rochelle Silva,Ke Zhao et al.
Canwei Mao et al.
Solid-contact ion-selective electrodes often struggle with potential stability during and between measurements. The potential drift significantly limits the reliability of the signal readout of ion-selective electrodes (ISEs), thereby limit...
The Influence of Single-Stranded or Double-Stranded DNA Tags on Ligand Binding Affinity in DNA-Encoded Libraries [0.03%]
单链或双链DNA标签对基于DNA的编码库中配体结合亲和力的影响
Philipp Bittner,Andreas Gloger,Julian A Harrison et al.
Philipp Bittner et al.
DNA-encoded libraries have become widely used in drug discovery, and several different setups to link chemical compounds to DNA have been employed in the field, including single-stranded and double-stranded DNA tags as well as a variety of ...
Multi-sphere Cascade DNA Reaction Amplified "On-Super On-Off" PEC Sensor for Sensitive Detection of Pax-5a Gene [0.03%]
多级滚环扩增的“开超开关”光电化学传感器用于Pax-5a基因检测
Yuming He,Yue Zhang,Yujie Zhou et al.
Yuming He et al.
Pax-5a gene, as a nucleic acid biomarker closely associated with B-cell acute lymphoblastic leukemia (B-ALL), holds significant potential for early disease diagnosis. In this study, we developed a highly accurate and efficient "on-super on-...
Spherical Acoustic Resonator-Based Quartz-Enhanced Photoacoustic-Photothermal Dual Spectroscopy Sensing [0.03%]
基于球形声学谐振器的石英增强光声光热双谱学检测
Chenzhao Sang,Chu Zhang,Runqiu Wang et al.
Chenzhao Sang et al.
In this paper, a single-quartz-enhanced photoacoustic-photothermal dual spectroscopy sensor based on a spherical acoustic resonator (SAR) is reported for the first time. The dual spectroscopy of quartz-enhanced photoacoustic spectroscopy (Q...
A 1H Background-Free 3D Printing Digital Light Processing Resin for Applications in NMR Spectroscopy [0.03%]
一种适用于核磁共振光谱技术的高分辨率1H背景免去除的三维打印数字光处理树脂
Peter M Costa,Katrina Steiner,Daniel H Lysak et al.
Peter M Costa et al.
Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique with a wide range of applications. To support the analysis of diverse and complex samples, various NMR tools and accessories have been created. Three-dimension...
DNA Nanocage-Based Artificial Receptor Generator for Hydrophobic Interaction-Based Specific Membrane Anchoring [0.03%]
基于疏水作用的特异性膜锚定的DNA纳米笼人工受体发生器
Shuoyao He,Yuqi Zeng,Yulin Du et al.
Shuoyao He et al.
Membrane receptor recognition is a specific biotargeting strategy for disease diagnosis and treatment, but it suffers from insufficient receptor expression levels. Hydrophobic interaction-based membrane anchoring strategy allows high anchor...
A New Biomarker for Predicting the Abscopal Effect: Quantifying Polyclonal Effector Tumor Antigen-Specific T Cells by Using Nanoparticles Loading Whole Tumor Antigens [0.03%]
一种预测远隔效应的新生物标志物：利用载有全肿瘤抗原的纳米颗粒量化多克隆效应瘤抗原特异性T细胞
Zhunyi Gao,Jiao Xue,Ziwei Qi et al.
Zhunyi Gao et al.
Radiation therapy (RT) plays important roles in cancer treatment, and the efficacy of RT depends on the abscopal effect, which results in the regression of distant and untreated tumors through localized irradiation of a single tumor lesion....
Antifouling Molecularly Imprinted Photoelectrochemical Sensors for Ultrasensitive and Selective Detection of the Sulfamethoxazole Antibiotic [0.03%]
抗生物污染的分子印迹光电化学传感器超灵敏特异检测磺胺甲恶唑抗生素
Minjiao Xia,Xiangya Zhang,Linlin Zhang et al.
Minjiao Xia et al.
Sulfamethoxazole (SMX) is a widely used antibiotic with toxic and persistent residues, which poses potential health risks in aquatic environments. However, reliable and accurate detection is impeded by the nonspecific adsorption of interfer...
Monitoring Molecular Uptake and Cancer Cells' Response by Development of Quantitative Drug Derivative Probes for Chemical Imaging [0.03%]
开发定量药物衍生物探针进行化学 imaging监测分子摄取和癌细胞的响应
Pei-Hsuan Hsieh,Shu-An Hsieh,Craig Richard et al.
Pei-Hsuan Hsieh et al.
Infrared (IR) spectroscopic imaging combines the molecular specificity of vibrational spectroscopy with imaging capabilities of microscopy, potentially allowing for simultaneous quantitative observations of drugs and cellular response. Howe...
Calibration Transfer of Deep Learning Models among Multiple Raman Spectrometers via Low-Rank Adaptation [0.03%]
基于低秩自适应的多拉曼光谱仪深度学习模型校正传递方法
Jiahui Lai,Miaomiao Li,Song Chen et al.
Jiahui Lai et al.
While deep learning-enhanced Raman spectroscopy enables rapid sample analysis, model portability among spectrometers remains hindered by systematic interdevice variations. In this study, a Low-Rank Adaptation-based Calibration Transfer meth...