Biomineralized Electroactive Microbe as the Whole-Cell Electrical Transducer for Electrochemically Online Monitoring of Lactic Acid Fermentation [0.03%]
一种生物矿化电活性微生物整细胞转换器用于在线监测乳酸发酵的电化学传感器
Jinming Zhao,Yanfei Lei,Pengjie Wang et al.
Jinming Zhao et al.
Electroactive bacteria (EAB) hold great promise for the development of electrochemical biosensors given their unique ability to transfer electrons extracellularly via specialized pathways, a process termed extracellular electron transfer (E...
Serum SERS Analysis Reveals Amino Acid- and Protein-Associated Vibrational Features for Subtype Identification in Acute Lymphoblastic Leukemia [0.03%]
急性淋巴细胞白血病亚型识别的血清SERS分析及氨基酸和蛋白质相关振动特征研究
Mengyao Wang,Dandan Li,Yue Duan et al.
Mengyao Wang et al.
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children. Current clinical diagnosis primarily relies on invasive detection methods, while molecular subtyping remains a complex and time-consuming process. Thi...
Discovery of Novel Multifunctional Paramagnetic Platforms: Cell Sorting and Theranostics Based on Active Molecules of Vascular Normalization [0.03%]
新型多功能顺磁平台的发现：基于血管正常化活性分子的细胞分选和诊疗一体化研究
Yanchen Li,Jin Wang,Tingting Liu et al.
Yanchen Li et al.
The novel multifunctional theranostic platform is highly regarded in clinical applications, often achieving desired outcomes in real-time tumor monitoring and personalized treatment. Paramagnetic micron/nanoparticles often exhibit strong ma...
3D-Printed Array Helical Monolithic Column Chip with Hierarchical Porous Structure for High-Throughput ICP-MS Analysis of Trace Rare-Earth Elements [0.03%]
一种具有分层多孔结构的3D打印阵列螺旋单片芯片用于稀土超痕量元素的高通量ICP-MS分析
Lei Cheng,Man He,Beibei Chen et al.
Lei Cheng et al.
Three-dimensional printing (3DP) technology enables the flexible fabrication of integrated monolithic microextraction chips for high-throughput sample pretreatment. Meanwhile, the extraction performance of 3DP-based channels is largely limi...
Sensor Arrays Based on Supramolecular Compound Calixarene: Innovative Breakthroughs in the Detection of Tumor-Associated Carbohydrate Antigens [0.03%]
基于超分子化合物Calixarene的传感器阵列在肿瘤相关糖类抗原检测中的创新突破
Yitong Li,Guanglian Zhou,Qianru Xu et al.
Yitong Li et al.
Abnormal glycosylation is widespread in cancer, and the overexpression of glycoantigens is a manifestation of glycosylation abnormalities. Tn antigen, sTn antigen, and T antigen are known as tumor-associated glycoantigens, and their express...
Microfluidic Generation of Oxidized Phospholipid Gradients in Supported Lipid Bilayers to Examine Scavenger Receptor Interactions [0.03%]
用于研究清道夫受体相互作用的支撑脂质双层中的氧化磷脂梯度的微流体生成
Brett A Berger,Turner P Brown,Wonpil Im et al.
Brett A Berger et al.
Reactive oxygen species (ROS) are responsible for the oxidative truncation of polyunsaturated fatty acids (PUFAs). The products of these reactions have been implicated in many diseases such as cancer and atherosclerosis. As increasing atten...
GSH and Halides Directed Controllable Synthesis of Chiral Gold Nanostars for Sensitive Diagnosis of Nephritis Types Using SERS and Transformer Neural Network [0.03%]
基于拉曼和神经网络的肾炎分型敏感诊断用手性金纳星可控合成及机理研究
Tingyang Xing,Panyi Mao,Shixian Wang et al.
Tingyang Xing et al.
Surface-enhanced Raman spectroscopy (SERS) has shown potential for early disease diagnosis via urinary metabolomics, but still faces challenges in achieving stable hot spots and processing complex clinical data. In this study, the preparati...
Characterization of Cross-Linked Elastomer Networks by Thermal Desorption/Pyrolysis Direct Analysis in Real-Time Mass Spectrometry (TDPy-DART-MS) [0.03%]
热解直接分析实时质谱法表征交联的弹性体网络(TDPy-DART-MS)
Calum Bochenek,Chrys Wesdemiotis
Calum Bochenek
Tires are complex polymeric materials composed of rubber elastomers (both natural and synthetic), fillers, steel wire, textiles, and a range of antioxidant and curing systems. These constituents are distributed differently among the various...
Programmable Dual-Phase Electrochemical Biosensor Combines Homogeneous CRISPR/Cas12a Activation with Interfacial Poly-G Signaling for miRNA-21 Detection [0.03%]
基于界面聚聚电解质信号放大与CRISPR-Cas12a酶促反应激活的双模式电化学生物传感器用于microRNA-21检测
Jia Zhao,Zhuqi Sui,Yi Wang et al.
Jia Zhao et al.
Despite the promise of electrochemical biosensors in amplified nucleic acid diagnostics, existing high-sensitivity platforms often rely on a multilayer surface assembly and cascade amplification confined to the electrode interface. These st...
Background-Free Rolling Circle Amplification for SERS Bioassay Using a Chimeric Hairpin-Integrated CRISPR/Cas12a System [0.03%]
基于杂合发夹型CRISPR/Cas12a系统的无背景信号等离子体核酸信号放大检测体系
Xian-Ming Guo,Shi-Ying Fu,Yu-Qing Wang et al.
Xian-Ming Guo et al.
Rolling circle amplification (RCA) has revolutionized nucleic acid detection owing to its isothermal simplicity. However, over two decades of clinical application have been hampered by off-target amplification and incompatibility with doubl...