Minimally Invasive Single-Cell Metabolomics Analysis to Unveil Different Trajectories of Individual Cells in Ferroptosis [0.03%]
微创单细胞代谢组学分析揭示铁死亡中各个体细胞的不同轨迹
Dandan Xia,Rong Jin,Le Tong et al.
Dandan Xia et al.
Existing cellular heterogeneity necessitates continuous analysis in a single cell to capture dynamic information. However, current mass spectrometry-based single-cell metabolomics analysis is a destructive technique and cannot perform multi...
Direct Visualization and Quantitative Modeling of Mass Transport Limitation in Biomolecular Kinetics via Imaging-Based Meta-SPR [0.03%]
基于成像的元SPR生物分子动力学直接可视化和定量建模及质量传递限制量化
Mingqian Chen,Jiacong Li,Yuhong Li et al.
Mingqian Chen et al.
Directly observing how mass transport limitation (MTL) distorts biomolecular kinetics has long remained out of reach. Here, we harness an imaging-based metasurface plasmon resonance (Meta-SPR) platform to both visualize and chemically quant...
SERS-Enhanced CRISPR Biosensors: A Platform for Ultrasensitive Molecular Diagnostics [0.03%]
基于SERS增强的CRISPR生物传感器：一种超灵敏分子诊断平台
Navid Rabiee
Navid Rabiee
Ultrasensitive Electrochemiluminescence Nanoprobe for Early Screening and Early Diagnosis of Cervical Cancer [0.03%]
用于宫颈癌早期筛查和诊断的超高灵敏电化学发光纳米探针
Xinhui Tang,Xiaoting Peng,Weina Zhang et al.
Xinhui Tang et al.
High-risk HPV-16 infection is strongly linked to cervical cancer, making its quantitative detection vital for early screening and early diagnosis. However, accurate detection of HPV-16 DNA is challenging due to the low viral load and biomol...
Orthogonal NIR/Ratiometric Probe for Simultaneous Imaging of NO and ATP in Acute Lung Injury: Elucidating Metabolic Dysregulation and Therapeutic Screening [0.03%]
急性肺损伤中NO和ATP的同时成像的正交NIR/比色探针：阐明代谢失调及药物筛选
Xinyue Li,Jinzhen Zheng,Ning Li et al.
Xinyue Li et al.
Acute lung injury (ALI) involves severe mitochondrial dysfunction, where the dynamic interplay between nitric oxide (NO) and adenosine triphosphate (ATP) remains elusive due to the lack of tools for their simultaneous visualization. Here, w...
A Novel, Low-Voltage-Excited Luminol-OH- Electrochemiluminescence System for Ultrasensitive Biosensing [0.03%]
一种新颖的低电压激发鲁米诺羟自由基电致化学发光体系用于超高灵敏度生物传感
Ting Hu,Chenglong Wang,Zihan Tang et al.
Ting Hu et al.
Sensitive and accurate detection of low-abundance protein biomarkers is critical in biomedical research. In this work, a novel luminol-OH--Pd-WOx/CNT electrochemiluminescence (ECL) system was developed, which is capable of generating intens...
Accelerated dl-Amino Acid Quantification of Deep Sea Water from Toyama Bay and Anti-Aging Activity Investigation Using Caenorhabditis elegans [0.03%]
加速量化Toyama湾深海水中dl-氨基酸以及使用Caenorhabditis elegans研究抗衰老作用
Takahiro Takayama,Haruto Iwata,Reina Fujio et al.
Takahiro Takayama et al.
Deep seawater (DSW), defined as seawater deeper than 200 m, has notable applications in various fields such as energy, agriculture, food, cosmetics, and public health. Several studies have attributed its utility to mineral effects; however,...
Interfacial Interaction Monitoring and Constitutional Isomer Discrimination Using a Graphene-Integrated Terahertz Metasurface [0.03%]
基于石墨烯集成太赫兹 metamaterial 的界面交互监测及构造异构体识别研究
Taeyeon Kim,Jaehun Park,Seongwon Gim et al.
Taeyeon Kim et al.
Monitoring and discrimination of molecular behavior in isomers remain a longstanding challenge due to similar chemical compositions, although they have functionally critical differences. Due to the consistent demand for molecular design/str...
A Depth-Controlled Longitudinal Cutting Strategy Enhances MALDI-MSI of Entire Leaves [0.03%]
一种深度可控的纵向切割策略可增强整个叶片的MALDI-MSI性能
Ying Chen,Chunping Tang,Jian Sui et al.
Ying Chen et al.
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) enables spatial analysis of endogenous metabolites in plant leaves, contributing to insights into the complex chemical, spatial, and temporal variations in pl...
MOSCAT: Aldehyde-Selective Chemical Proteomics for Site-Specific Profiling of Cinnamaldehyde Targets in Living Cells [0.03%]
MOSCAT：用于活细胞香草醛特异目标精确定量的亚硝基苯胲胺化学蛋白质组学技术
Kailu Tian,Jiahua Zhou,Yanan Li et al.
Kailu Tian et al.
Cinnamaldehyde (CA), a bioactive compound from cinnamon, exhibits diverse pharmacological activities including anti-inflammatory and anticancer effects. However, comprehensive exploration of the target landscape of CA at site-specific resol...