Menglin Zhou,Chenhao Gong,Shan Cong et al.
Menglin Zhou et al.
Mass spectrometry (MS) is central to molecular discovery, yet the interpretation of tandem mass spectra (MS/MS) remains limited by database dependence and an incomplete structural resolution. Here, we explore whether large language models (...
Boronic Acid-Functionalized MOFs Enable Ultrasensitive Proteomic Profiling of Ultratrace Plasma for Triple-Negative Breast Cancer Diagnosis [0.03%]
硼酸官能化金属有机框架用于超灵敏血浆蛋白组学分析以检测三阴性乳腺癌
Shuang Zhang,Zhixiao Xu,Haoni Yan et al.
Shuang Zhang et al.
Blood-based proteomics holds great promise for noninvasive disease diagnostics, yet remains constrained by large sample requirements, laborious preprocessing, and limited sensitivity. Here, we present a streamlined workflow for ultratrace p...
Wearable and Multimodal Electrochemical Hydrogel Sensor for Real-Time Non-Invasive Sweat Glucose Monitoring [0.03%]
用于实时无创汗液葡萄糖监测的可穿戴多模态电化学水凝胶传感器
Yilin Liang,Tianjun Zhou,Jiarui Liu et al.
Yilin Liang et al.
Noninvasive sweat glucose monitoring is a promising strategy for real-time health management. In this study, we developed a flexible electrochemical sensor platform based on gold nanorods@polylysine-glucose oxidase (AuNRs@PLL-GOx) composite...
Spatial Synergy of Crown Ether Groups in Covalent Organic Framework Nanochannels Enabling Efficient Monovalent Cation Separation [0.03%]
冠醚基团在共价有机框架纳米通道中的空间协同作用实现高效单值阳离子分离
Ri-Jian Mo,Zhong-Yan Xu,Shuang Chen et al.
Ri-Jian Mo et al.
Selective ion transport in nanochannels is critical not only for ion extraction but also for analytical applications requiring high-precision ion isolation prior to detection. However, for ions with identical charge and similar size (e.g., ...
Integrating Suspect and Nontargeted Screening for Food Safety Testing: A Case Study of Bee Pollen Supplements [0.03%]
可疑和非目标筛查在食品安全检测中的应用——以蜂花粉补充剂为例
Susannah M Heeren,Nynke I Kramer,Laura Righetti
Susannah M Heeren
Natural food supplements, including bee pollen supplements, are increasingly popular, yet they may hide safety issues arising from concentrated chemicals, ranging from natural toxins to anthropogenic contaminants. To assess their safety, me...
Spatially Confined Photoinduced Penning Ionization for Highly Sensitive Mass Spectrometry [0.03%]
空间限制的光诱导Penning离子化高灵敏度质谱法
Yi Yu,Hang Li,Zhenyuan Zhang et al.
Yi Yu et al.
In vacuum ultraviolet (VUV) lamp-based photoionization mass spectrometry (PI-MS), the axially mounted configuration exhibits higher sensitivity due to a longer light absorption path. However, VUV light irradiation of the metal surfaces with...
A Chemical and Biological Portable Mass Spectrometer (CB-pMS) with Automated Sampling and Hybrid Ionization for Online Detection of Bioaerosols and VOCs [0.03%]
具有自动取样和混合电离的化学与生物离子便携式质谱仪（CB-pMS），用于在线检测生物气溶胶和VOCs
Baokun Yang,Shiyu Du,Xiao Han et al.
Baokun Yang et al.
The escalating threat of airborne chemical and biological pollutants demands real-time monitoring technologies capable of simultaneously detecting both classes of contaminants. Conventional analytical methods are frequently constrained by s...
CommAST Enables Antibiotic Susceptibility Testing at the Gut Microbiota Community Level [0.03%]
CommAST使能在肠道微栖境层面进行抗生素敏感性测试
Chenling Ding,Weiqi Wu,Yanqi Zhang et al.
Chenling Ding et al.
Knowledge of the susceptibility of gut bacteria to antibiotics is important for understanding the frequent gut microbiota dysbiosis caused by oral antibiotic administration. However, traditional antimicrobial susceptibility testing (AST) me...
Aptamer-Modified Nanostructured Particles Exhibiting Sensitive Cell-Scale FRET Enable Precise Pancreatic Cancer Diagnosis [0.03%]
一种适用于敏感细胞荧光共振能量转移的适配体修饰纳米结构颗粒用于精准胰腺癌诊断
Na He,Yixi Zhang,Yuemeng Yang et al.
Na He et al.
Diagnosis of pancreatic cancer (PC) at early stage remains a challenge due to the limited sensitivity and specificity of current biomarkers. Here, we develop nanostructured magnetic particles (NMPs) exhibiting highly sensitive and specific ...
Multivalence Aptamers Enhance Transmembrane Efficiency of Localized Catalytic Hairpin Assembly-Based Nanomachine for Sensitive Cell Imaging [0.03%]
多重价适配体增强局部催化发夹组装纳米机器的跨膜效率用于敏感细胞成像
Xudong Zhang,Chenxin Ma,Xueyuan Zhang et al.
Xudong Zhang et al.
As a promising scaffold material, DNA tetrahedrons (TDNs) were integrated with localized catalytic hairpin assembly (LCHA) to develop a nanomachine. However, the TDN nanomachine, as an exogenous material, has difficulty directly penetrating...