High-Fidelity Tracking of Endocytosis in Cancer Cells under Cellular Stress Using a Long-Term Anchoring Cell Membrane Fluorescent Probe [0.03%]
一种长效锚定细胞膜荧光探针的开发及其在细胞应激下对癌细胞内吞作用高保真追踪中的应用研究
Xin Peng,Chuixi Kong,Shuyi Jiang et al.
Xin Peng et al.
Endocytosis plays a critical role in regulating protein dynamics, and cancer cells often exploit this process to enhance their survival capacity. However, the development of reliable tools for high-fidelity visualization of endocytosis unde...
Charged Water Enables the Determination of Inherited Metabolic Diseases by Mass Spectrometry [0.03%]
带电的水能够通过质谱法确定遗传代谢疾病
Yali Yang,Jie Jiang,Jing He et al.
Yali Yang et al.
Inherited metabolic diseases (IMDs) have drawn considerable attention due to their disruption of normal metabolic pathways. However, conventional extraction techniques are predominantly offline and time-consuming, making them inadequate for...
43Ca Freeze-Quenched MAS-DNP for the Characterization of Transient Phases Involved in Nonclassical Formation of Hydroxyapatite [0.03%]
43Ca快速冷冻淬灭MAS-DNP用于表征非经典羟基磷灰石形成过程中的瞬时相态
Tristan Georges,Romain Chèvre,Jean-Michel Guigner et al.
Tristan Georges et al.
Calcium orthophosphates, such as hydroxyapatite (HAP), have been shown to follow nonclassical nucleation and crystallization mechanisms involving intermediate species, including solute prenucleation species (PNS) that precede solid transien...
Rapid Screening of Methicillin-Resistant Staphylococcus aureus Using MALDI-TOF MS and Machine Learning: A Randomized, Multicenter Study [0.03%]
采用基质辅助激光解吸电离飞行时间质谱和机器学习快速筛查耐甲氧西林金黄色葡萄球菌：一项多中心随机研究
Dongeun Yong,Jeong Su Park,Kyungnam Kim et al.
Dongeun Yong et al.
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections including bacteremia. The rapid detection of MRSA is essential for prompt treatment and improved outcomes. However, traditional MRSA scr...
Fluorescent DNA-Polymer Enables Signal Amplification and Precise Protein Localization in Immunofluorescence Imaging [0.03%]
荧光DNA-聚合物在免疫荧光成像中实现信号放大和精确的蛋白质定位
Qin Fu,Yicun Li,Yuheng Lv et al.
Qin Fu et al.
The DNA-barcoding method has revolutionized immunofluorescence imaging, offering a transformative approach to protein visualization and analysis. However, achieving effective signal amplification while maintaining precise target localizatio...
Hyperbranched Rolling Circle Amplification Enabled Nanopore Sensing Platforms for Ultrasensitive Multiplex MicroRNA Detection and Logic-Gated Molecular Diagnostics [0.03%]
超分支滚环放大技术激活的纳米孔检测平台用于超高灵敏多重microRNA检测及逻辑门控分子诊断
Siqi Zhang,Mengkang Zheng,Wei Shi et al.
Siqi Zhang et al.
MicroRNAs (miRNAs) have emerged as crucial biomarker candidates and therapeutic targets for various diseases and cancers, where precise trace-level detection holds significant value for early clinical diagnosis. However, the development of ...
Dual-Mode Electrochemical and Electrochemiluminescent Aptamer Biosensors for Point-of-Care Detection of Cardiac Troponin I [0.03%]
用于床旁检测心肌肌钙蛋白I的双模式电化学生物传感器
Mingang Liao,Zhuoliang Hu,Xilin Chen et al.
Mingang Liao et al.
Acute myocardial infarction (AMI), a leading cause of global mortality, requires the rapid and accurate detection of cardiac troponin I (cTnI) for prompt intervention. To address this, we present an innovative dual-mode electrochemiluminesc...
Retraction of "Label-Free Light Scattering Imaging with Purified Brownian Motion Differentiates Small Extracellular Vesicles in Cell Microenvironments" [0.03%]
撤回：“利用纯净布朗运动的无标记散射光学成像技术区分细胞微环境中较小的细胞外囊泡”
Nebras Ahmed Mohamed,Zhuo Wang,Qiao Liu et al.
Nebras Ahmed Mohamed et al.
Composite Fluorescence Encoding Technology Based on Tetrahedral DNA Framework for Logical Distinction and Multiplexed Recognition [0.03%]
基于四面体DNA框架的复合荧光编码技术用于逻辑区分和多重识别
Xiaoshuang Zhao,Yi Xu,Ning Dai et al.
Xiaoshuang Zhao et al.
Multiplexed bioanalysis and deciphering their regulatory relationships have great significance for the diagnosis and treatment of diseases. In this study, a composite fluorescence encoding technology (CFET) combining spectrum and intensity ...
Collaborative Internal Cavity Effect and Interfacial Modulation Mechanism for Boosting Deep Learning-Powered Immunochromatographic Pathogen Detection [0.03%]
协同内部腔室效应和界面调制机制助力深度学习驱动的免疫层析病原体检测
Yuechun Li,Chenxin Ji,Zhaowen Cui et al.
Yuechun Li et al.
Nanoenabled immunochromatographic assay (ICA) emerges as a powerful tool for pathogen diagnosis, yet current nanotechnologies are still constrained by inadequate light-matter interaction efficiency, sluggish nanomaterial flow dynamics, and ...