Enhanced Breath Aldehyde Analysis by Dual-Membrane-Assisted Charge Tagging, Enrichment, and Onsite Elution NanoESI-MS [0.03%]
双膜辅助电荷标记、富集及现场洗脱纳米喷雾离子源质谱分析增强的呼出气醛类检测
Beichen Zhu,Yifan Wei,Xiumei Zheng et al.
Beichen Zhu et al.
Aldehydes, crucial volatile organic compounds present in exhaled breath, have been established as promising biomarkers for cancer diagnosis. However, their rapid and sensitive detection through widely employed spray-based ionization mass sp...
The Role of Chloride in Raman Signal Enhancement by Electrochemical Silver Oxidation Revealed by Dark Field Microscopy [0.03%]
暗场显微揭示电化学银氧化中氯离子对拉曼信号增强的作用
Sheila Hernandez,Kevin Wonner,Pouya Hosseini et al.
Sheila Hernandez et al.
Raman spectroscopy is a widely used technique in several contexts, including chemical analysis, materials characterization, and catalysis. However, to exploit the high capacities of this technique, signal enhancement is needed. For this pur...
CRISPR/Cas12a Protein Switch Powered Label-Free Electrochemical Biosensor for Sensitive Viral Protease Detection [0.03%]
用于敏感病毒蛋白酶检测的CRISPR / Cas12a蛋白开关驱动的无标签电化学生物传感器
Tianyi Zhang,Yingying Zhao,Cong Zhu et al.
Tianyi Zhang et al.
Viral proteases are critical molecular targets in viral pathogenesis, representing pivotal biomarkers for understanding viral infection mechanisms and developing antiviral therapeutics. This study introduces a label-free electrochemical bio...
Examining Instrumental Factors Influencing the Performance of Data-Independent Acquisition Methods in Hydrogen/Deuterium Exchange Mass Spectrometry [0.03%]
氢/氘交换质谱中影响数据非依赖采集方法性能的仪器因素研究
Frantisek Filandr,Morgan Hepburn,Vladimir Sarpe et al.
Frantisek Filandr et al.
Hydrogen/deuterium exchange mass spectrometry (HX-MS) is a method used to study solution-phase protein structure and dynamics. Despite its many applications, HX-MS is limited in throughput because manual data analysis is still the norm. We ...
Novel Native Reversed-Phase Liquid Chromatography (nRPLC)/MS for Antibody-Drug Conjugates (ADCs) Characterization and Drug-Antibody Ratio (DAR) Assessment [0.03%]
新型本土反相液相色谱(nRPLC)/MS在抗体药物偶联物(ADCs)表征及药物抗体比(DAR)测定中的应用
Fengfei Ma,A Carl Sanchez,James Song et al.
Fengfei Ma et al.
Characterization of drug-antibody ratio (DAR) species in antibody-drug conjugates (ADCs) is crucial for assessing the developability/manufacturability and downstream development of drug candidates. Although hydrophobic interaction chromatog...
A Generalizable Screening Platform for Developing Functional Aptasensors [0.03%]
可用于开发功能性适配体传感器的通用筛选平台
Micaela Belleperche,Jiawen Liu,Yuhao Chen et al.
Micaela Belleperche et al.
Aptamers are versatile sensing elements for the construction of biosensors. A common approach for signal generation in "aptasensors" involves the displacement of short complementary "probes" resulting from conformational changes upon aptame...
Correction to "Native Capillary Nanogel Electrophoresis Assay of Inhibitors of Neuraminidases Derived from H1N1 and H5N1 Influenza A Pandemics" [0.03%]
对“来自H1N1和H5N1流感大流行的神经氨酸酶抑制剂的原位毛细管纳米凝胶电泳检测法”的勘误通知
Laura N Taylor,Lisa A Holland,Makenzie T Witzel
Laura N Taylor
Published Erratum
Analytical chemistry. 2025 Mar 31. DOI:10.1021/acs.analchem.5c01608 2025
Programmable AIESTA: All-in-One Isothermal Enzymatic Signal Transduction Amplifier for Portable Profiling [0.03%]
可编程的AIESTA：便携式分析用一体化等温酶信号转导放大器
Haoran Shen,Yanling Li,Kangling Tang et al.
Haoran Shen et al.
The Argonaute (Ago) protein exhibits high specificity in nucleic acid recognition and cleavage, making it highly promising for biosensing applications. Its potential is further enhanced by its independence from protospacer adjacent motif (P...
Ultrasensitive Detection of FLT3-ITD Mutations via Primer Competition Enhanced Mutant Accumulation [0.03%]
通过引物竞争增强突变累积实现FLT3-ITD突变的超灵敏检测
Ling Dai,Mengjun Deng,Kena Chen et al.
Ling Dai et al.
The in-frame internal tandem duplication of the FLT-3 gene (FLT3-ITD), a prevalent genetic aberration, significantly contributes to treatment failure and poor prognosis in acute myeloid leukemia (AML). A robust and cost-effective assay for ...
Effects of H2O and SF6 on CO Molecular Relaxation in a Cantilever-Enhanced Fiber-Optic Photoacoustic Sensor [0.03%]
H2O和SF6对悬臂梁增强型光纤光声传感器中CO分子弛豫的影响
Xinyu Zhao,Hongchao Qi,Yajie Zhang et al.
Xinyu Zhao et al.
The effects of H2O and SF6 on the relaxation rate of CO molecules are studied using a fiber-optic photoacoustic sensor (FOPAS) that integrates a resonant multipass photoacoustic cell with a fiber cantilever. The CO photoacoustic signal is e...