Accurate Single-Particle Tracking and Diffusion Measurement in Freestanding Lipid Bilayers and Model Membranes [0.03%]
单个颗粒在脂质双层和模型膜中的精确追踪及扩散测量
Lily Anne Van Ye,Richard D Michael,Joshua J Meyer et al.
Lily Anne Van Ye et al.
Single-particle tracking (SPT) in lipid bilayers offers a powerful means to investigate the dynamic interaction of individual molecules in a variety of model membranes. However, accurate diffusion characterization in freestanding bilayers r...
Untargeted Metabolomics for Forensic Body Fluid Identification-A Pilot Study [0.03%]
用于法医体液识别的未靶向代谢组学研究-一项初步研究报告
Meghna Swayambhu,Tom D Schneider,Janko Tackmann et al.
Meghna Swayambhu et al.
Determining the bodily origin of biological traces is a valuable tool in forensic investigations as it helps corroborate testimonies, reconstruct crime-related activities, and select relevant samples for further analysis. Current body fluid...
Sniffing Out Lung Cancer: Biomimetic Breath Analysis via a Deep Eutectic Solvent-Driven Colorimetric Sensor Array [0.03%]
电子鼻技术在呼吸组学中的研究进展及肺部疾病诊断应用探索
Shiva Pesaran,Zahra Shojaeifard,Javad Tashkhourian et al.
Shiva Pesaran et al.
Lung cancer remains the leading cause of cancer-related mortality worldwide, primarily due to the lack of accessible, noninvasive early diagnostic tools. Here, we present a novel paper-based colorimetric sensor array that leverages deep eut...
Catalase-Driven Microflow Displacement for Rapid, Visual Antimicrobial New SI file added.Susceptibility Testing [0.03%]
一种快速直观的抗菌药物敏感性试验的新方法——过氧化氢酶驱动微流控置换法新的附件文件已添加。
Yuexiao Jia,Xiaoqing Cai,Zhixin Li et al.
Yuexiao Jia et al.
Rapid and accurate antimicrobial susceptibility testing (AST) is essential for guiding effective antibiotic therapy and combating antimicrobial resistance (AMR). Here, we present an instrument-free phenotypic AST method that integrates cata...
Axially-Staggered-Trap Microplasma Source-Based Miniaturized Optical Emission Spectrometer for High-Performance Elemental Detection [0.03%]
基于轴向错位阱微等离子体源的高性能元素检测微型光学发射光谱仪
Meng Zhang,Qingsong Tang,Kai Li et al.
Meng Zhang et al.
To miniaturize a microplasma-based optical emission spectrometer with high performance, the spatial distribution of electron density and the spectral responses in a point-discharge (PD) microplasma were systematically studied. COMSOL simula...
Aptamers Generated by Multi-Strategy Selection Target FcγRI and Block IgG Fc-FcγRI Interaction [0.03%]
多策略筛选获得的靶向FcγRI抗体片段Fc功能区并阻断IgGFc与FcγRI相互作用的适配体
Jing Sheng,Tingrun Cui,Yang Xu et al.
Jing Sheng et al.
FcγRI, a high-affinity receptor for the Fc region of IgG, plays a pivotal role in bridging humoral and cellular immunity by mediating phagocytosis, and cytokine secretion to combat pathogens and maintain immune homeostasis. Developing high...
Macromolecule-Enriched Fluorescent Peptides Derived from Receptor Proteins for Sensitive Drug Identification via Differential Sensing [0.03%]
基于受体蛋白的富集宏分子荧光肽的敏感药物识别差分传感法
Shiqi Liuye,Tianhao Shi,Yang Zhou et al.
Shiqi Liuye et al.
Synthetic illicit drugs have posed severe threats to health and social security. Differential sensing integrated with multivariate data processing methods provides substantial benefits for the simultaneous detection of multiple drugs. Ratio...
Integrative Real-Time NMR and X-ray Crystallography Reveal Prostaglandin D2 Metabolism [0.03%]
整合的实时核磁共振和X射线晶体学揭示前列腺素D2代谢路径
Soichiro Ohta,Shigeru Shimamoto,Haruka Oda et al.
Soichiro Ohta et al.
Understanding the metabolic pathways and kinetics of prostaglandins is essential for elucidating their biological functions and therapeutic potential. Prostaglandin D2 (PGD2), a somnogen in the brain, undergoes nonenzymatic conversion into ...
Sensitive Detection of Chloramphenicol Using Electrochemiluminescence Imaging Based on a DNA Walker Coupled with Nanozyme Quenching Effect [0.03%]
基于DNA行走器结合纳米酶猝灭效应的氯霉素电化学发光成像检测法
Shuxian Han,Zhuangzhuang Ru,Nuo Zhang et al.
Shuxian Han et al.
Chloramphenicol (CAP), as a broad-spectrum antibiotic, can combat bacterial infections but can accumulate in the human body through food chains, leading to food safety issues. In this work, a novel electrochemiluminescence (ECL) biosensing ...
Deprotonated Nanofilms-Enabled Fluorescence-Colorimetric Dual-Mode Sensing of 3-Hydroxy-2-butanone [0.03%]
抗质子纳米膜增强的荧光-比色双模式3-羟基丁酮检测新模式研究
Xue Gu,Xinyu Gou,Yan Jiang et al.
Xue Gu et al.
3-Hydroxy-2-butanone (3H2B) is a key gaseous metabolite of Listeria monocytogenes, a potential lung cancer biomarker, and a widely used food flavoring agent, underscoring the demand for real-time monitoring solutions. In this study, we desi...