An Ultrasensitive Single-Particle Collision Electrochemical Immunoassay at Subfemtogram-per-Milliliter Levels via Cascaded Hybridization Chain Reaction Amplification [0.03%]
Jieyu Zhang,Qingying Gao,Fangfang Yang et al.
Jieyu Zhang et al.
Herein, we developed an ultrasensitive single-particle collision-based electrochemical immunosensing platform for detecting a total prostate-specific antigen (tPSA) as a model target. It relies on the collision events resulting from the enz...
Ratiometric Fluorescent Probe with Metal-Mediated Dual-Emission Centers for Ultrasensitive and Interference-Resistant SF6 Monitoring in High-Voltage Equipment [0.03%]
Xiaoxuan Sun,Jingyu Bao,Yawei Xie et al.
Xiaoxuan Sun et al.
Developing SF6 detection method with convenient, efficient, and interference-resistant is crucial for monitoring gas leaks in grid insulation systems. Here, we report a novel ratiometric fluorescent probe (NiCDs@MOF) with dual-emission cent...
Ti3C2/CuCoSe2 p-n Heterojunction: Preparation and Mechanism for Machine Learning-enhanced Electrochemical Sensing of Rutin [0.03%]
Qiang Li,Maoyuan Hu,Jianlong Li et al.
Qiang Li et al.
Rutin is widely employed as a therapeutic agent, but excessive intake may induce adverse reactions such as gastric discomfort, headache and dermatitis. However, reliably quantifying it in complex matrices remains a significant challenge. He...
Mazdak Afshar Bakshloo,Leïla Bechtella,Jianjun Tao et al.
Mazdak Afshar Bakshloo et al.
Achieving zero-dalton resolution─the discrimination of biomolecules with identical mass─remains a fundamental challenge in molecular analysis. Nanopore sensing can resolve short peptide isomers, but whether discrimination persists when pe...
Yating Hu,Junchi Song,Yuchen Li et al.
Yating Hu et al.
Conventional fluorescence-activated cell sorting (FACS) systems are usually expensive and require large sample volumes. In this study, we present a compact microfluidic system based on gradient dielectrophoresis (gDEP-μFACS). The device in...
Spatially Selective Diffusion-Ordered NMR Spectroscopy for High-Resolution Mixture Analysis in Inhomogeneous Magnetic Fields [0.03%]
Haolin Zhan,Qingjie Yang,Hanmin Li et al.
Haolin Zhan et al.
Diffusion-ordered NMR spectroscopy (DOSY) serves as a robust spectroscopic method for the analysis of intact mixtures by resolving the individual components and their diffusion properties. However, the ability of DOSY generally relies on sp...
A Phage Endolysin-Derived Binding Protein Targeting the LysM Motif Enables Highly Specific Identification of Acinetobacter baumannii [0.03%]
Shukho Kim,Yoon-Jung Choi,Md Shohel Rana et al.
Shukho Kim et al.
Acinetobacter baumannii, a member of the A. baumannii-calcoaceticus complex (ABC), is a major cause of hospital-acquired infections. Differentiating A. baumannii from other ABC species remains challenging. In this study, we developed a nove...
Multifunctional Core-Shell Nanodiamond Stationary Phase for Open-Tubular Capillary Electrochromatography: Synergistic Interactions and Exceptional Joule-Heat Dissipation [0.03%]
Lan Xia,Qifeng Fu,Zhining Xia
Lan Xia
Open-tubular capillary electrochromatography (OT-CEC) holds significant promise for microscale separations but is frequently constrained by trade-offs among phase stability, sample loadability, and the detrimental effects of Joule heating. ...
Fe-PNC Nanoenzyme-Enhanced Closed Bipolar Sensing Platform for Sensitive ECL/Fluorescence Detection and Imaging of miRNA-141 [0.03%]
Jing Liu,Mengjie Sun,Yufei Fan et al.
Jing Liu et al.
A closed-bipolar, dual-mode imaging biosensing platform is reported for the ultrasensitive detection and visualization of microRNA-141. The system integrates a T7 Exodriven cascade amplification circuit with an Fe-PNC nanozyme cathodic prob...
Electrochemiluminescence Biosensing Platform Based on CRISPR/Cas12a and DNA Nanotweezer-Mediated Catalytic Hairpin Assembly Amplification [0.03%]
Qian Wang,Mengting Sheng,Yuxin Zheng et al.
Qian Wang et al.
The detection of microRNAs (miRNAs) biomarkers has great potential in the early diagnosis of acute myocardial infarction (AMI). Herein, we constructed an electrochemiluminescence biosensing platform based on DNA nanotweezer (DNT)-mediated c...