High-Throughput Chiral LC-MS/MS Method Using Overlapping Injection Mode for the Determination of Pantoprazole Enantiomers in Human Plasma with Application to Pharmacokinetic Study [0.03%]
一种高通量的手性LC-MS/MS方法用于人血浆中泮托拉唑对映异构体的测定及其药代动力学研究应用
Shengni Li,Huafang Jiang,Yiya Wang et al.
Shengni Li et al.
A sensitive and high-throughput chiral liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of R-pantoprazole and S-pantoprazole in human plasma. Sample extraction was carried out by using...
Synthesis and Enantiomeric Recognition Studies of Optically Active Pyridino-Crown Ethers Containing an Anthracene Fluorophore Unit [0.03%]
手性吡啶冠醚-蒽复合物的合成及其对映体识别研究
Balázs Szemenyei,Ildikó Móczár,Dávid Pál et al.
Balázs Szemenyei et al.
Novel enantiopure pyridino-18-crown-6 ether-based sensor molecules containing an anthracene fluorophore unit were synthesized. Their enantiomeric recognition abilities toward the enantiomers of 1-phenylethylamine hydrogen perchlorate (PhEt)...
Stereochemical Properties of Multidentate Nitrogen Donor Ligands and Their Copper Complexes by Electronic CD and DFT [0.03%]
多齿氮配体及其铜配合物的立体化学性质的电子圆二色谱和DFT研究
Mohammad Reza Poopari,Zahra Dezhahang,Yunjie Xu
Mohammad Reza Poopari
UV-Vis and electronic circular dichroism (ECD) spectroscopy, complemented with Density Functional Theory (DFT) calculations, were used to elucidate the structural diversities of three multidentate nitrogen donor ligands and two associated c...
An Edge Selection Mechanism for Chirally Selective Solubilization of Binaphthyl Atropisomeric Guests by Cholate and Deoxycholate Micelles [0.03%]
胆酸和脱氧胆酸胶束对联萘客体手性溶剂化的边缘选择机制
Kyle W Eckenroad,Gregory A Manley,Jenna B Yehl et al.
Kyle W Eckenroad et al.
Combining micellar electrokinetic capillary chromatography (MEKC) and nuclear magnetic resonance (NMR) experimentation, we shed light on the structural basis for the chirally selective solubilization of atropisomeric binaphthyl compounds by...
Facile Diastereoseparation of Glycosyl Sulfoxides by Chiral Stationary Phase [0.03%]
手性固定相简单地分离差向异构糖基亚砜化合物
Tohru Taniguchi,Mai Asahata,Akihito Nasu et al.
Tohru Taniguchi et al.
Separation of the diastereomers of glycosyl sulfoxides differing in the sulfur chirality has been difficult. This article presents a fast and scalable method for their diastereoseparation using a chiral stationary phase. The usefulness of t...
Effects of Hexane in Supercritical Fluid Chromatography for the Separation of Enantiomers [0.03%]
用于拆分对映异构体的超临界流体色谱法中正己烷的影响
Haihong Wu,Stanley Yu,Lu Zeng
Haihong Wu
Supercritical fluid chromatography (SFC), operated in conventional mode, is normally recognized as normal phase chromatography, and uses a solvent combination of supercritical CO2 and alcohols to separate compounds. Hexane, a commonly used ...
Chiral HPLC Separation, Absolute Structural Elucidation, and Determination of Stereochemical Stability of trans-Bis[2-(2-pyridinyl)aminophenolato] Cyclotriphosphazene [0.03%]
反式-双[2-(2-吡啶基)氨基苯酚]三磷杂环己二烯的手性HPLC拆分、绝对构型鉴定及其立体化学稳定性研究
Kazumasa Kajiyama,Yuki Setone,Kouki Aoyagi et al.
Kazumasa Kajiyama et al.
Chiral high-performance liquid chromatography (HPLC) separation of trans-bis[2-(2-pyridyl)aminophenolato] dichlorocyclotriphosphazene was achieved and the absolute configuration of was assigned to be S,S by single-crystal X-ray structural a...
Optical Activity Governed by Local Chiral Structures in Two-Dimensional Curved Metallic Nanostructures [0.03%]
二维曲面金属纳米结构中的手性光学活动性调控
Tetsuya Narushima,Shun Hashiyada,Hiromi Okamoto
Tetsuya Narushima
Chiral nanostructures show macroscopic optical activity. Local optical activity and its handedness are not uniform in the nanostructure, and are spatially distributed depending on the shape of the nanostructure. In this study we fabricated ...
Physical-Chemical Properties of the Chiral Fungicide Fenamidone and Strategies for Enantioselective Crystallization [0.03%]
fungicide fenamidone的物理化学性质及其对映体选择性结晶策略
Anne-Kathleen Kort,Heike Lorenz,Andreas Seidel-Morgenstern
Anne-Kathleen Kort
Thermodynamic and kinetic parameters are of prime importance for designing crystallization processes. In this article, Preferential Crystallization, as a special approach to carry out enantioselective crystallization, is described to resolv...
Synthesis of Novel Chiral Sulfonamide-Bearing 1,2,4-Triazole-3-thione Analogs Derived from D- and L-Phenylalanine Esters as Potential Anti-Influenza Agents [0.03%]
以D-和L-苯丙氨酸酯为原料合成新型手性磺胺基-1,2,4-三氮唑-3-硫酮衍生物作为潜在的抗流感化合物
Eyüp Başaran,Ayşegül Karaküçük-Iyidoğan,Dominique Schols et al.
Eyüp Başaran et al.
Novel enantiopure 1,2,4-trizole-3-thiones containing a benzensulfonamide moiety were synthesized via multistep reaction sequence starting with D-phenylalanine methyl ester and L-phenylalanine ethyl ester as a source of chirality. The chemic...