Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives [0.03%]
尼泊酸对映过量的测定及其1-（7-硝基苯并[c][1,2,5]恶二唑-4-基）衍生物的研究
Simone K Schmidt,Georg Höfner,Klaus T Wanner
Simone K Schmidt
For the enantiopure synthesis of novel chiral GABA uptake inhibitors, nipecotic acid (1) is an important key precursor. To characterize accurately the pharmacological activity of these interesting target compounds, the determination of the ...
Chirality-specific lift forces of helix under shear flows: Helix perpendicular to shear plane [0.03%]
螺旋结构在剪切流体中的手性特异性提取力：螺旋轴垂直于剪切平面
Qi-Yi Zhang
Qi-Yi Zhang
Chiral objects in shear flow experience a chirality-specific lift force. Shear flows past helices in a low Reynolds number regime were studied using slender-body theory. The chirality-specific lift forces in the vorticity direction experien...
Distribution of enantiomers of volatile organic compounds in selected fruit distillates [0.03%]
几种果酒中挥发性手性有机化合物的对映体分布规律
Olga Vyviurska,Helena Zvrškovcová,Ivan Špánik
Olga Vyviurska
The enantiomer ratios of chiral volatile organic compounds in fruit distillates were determined by multidimensional gas chromatography using solid-phase microextraction (SPME) as a sample treatment procedure. Linalool and its oxides, limone...
Stereoselective bioaccumulation, transformation, and toxicity of triadimefon in Scenedesmus obliquus [0.03%]
丙环唑在斜生栅藻中的立体选择性富集、转化及其毒性研究
Peng Xu,Ledan Huang
Peng Xu
In this study the stereoselective bioaccumulation and transformation of triadimefon and the toxicity of triadimefon and its metabolite triadimenol to the green algae Scenedesmus obliquus were studied. In growth inhibition experiments, triad...
Direct chiral separations of the enantiomers of phenylpyrazole pesticides and the metabolites by HPLC [0.03%]
手性柱直接拆分联苯肼酯类农药及代谢产物对映体的高效液相色谱法
Jing Gao,Han Qu,Chuntao Zhang et al.
Jing Gao et al.
The enantiomeric separation of the enantiomers of three phenylpyrazole pesticides (fipronil, flufiprole, ethiprole) and two fipronil metabolites (amide-fipronil and acid-fipronil) were investigated by high-performance liquid chromatography ...
Enantioseparation of nine indanone and tetralone derivatives by HPLC using carboxymethyl-β-cyclodextrin as the mobile phase additive [0.03%]
手性环糊精衍生物作为拆分剂的高效液相色谱法拆分茚酮和四氢萘酮映异构体的研究
Xiaoyu Hu,Xin Guo,Shuo Sun et al.
Xiaoyu Hu et al.
High-performance liquid chromatography (HPLC) is a powerful method in the area of chiral separation. In this study, a method of HPLC using carboxymethyl-β-cyclodextrin (CM-β-CD) as chiral selector was developed for enantioseparation of ni...
Comparison of intestinal permeability and p-glycoprotein effects on the intestinal absorption of enantiomers of 2-(2-hydroxypropanamido) benzoic acid in rats [0.03%]
Racemic消旋混合物2-（2-羟基丙酰氨基）苯甲酸光学异构体在大鼠肠道吸收的手性差异及外排载体p-糖蛋白的影响作用比较研究
Qili Zhang,Meiyan Zhang,Danlin Wang et al.
Qili Zhang et al.
The purpose of this study was to compare intestinal permeability between enantiomers of 2-(2-hydroxypropanamido) benzoic acid ((R)-/(S)-HPABA), a marine-derived antiinflammatory drug, using an in situ single-pass intestinal perfusion (SPIP)...
Using chiral peptide substitutions to probe the structure function relationship of a key residue of Aβ42 [0.03%]
采用手性肽替代的方法研究Aβ42关键位点的结构功能关系
Christopher J A Warner,Subrata Dutta,Alejandro R Foley et al.
Christopher J A Warner et al.
Amyloid beta-protein 42 plays an important role in the onset and progression of Alzheimer's disease. Familial mutations have identified the glutamate residue 22 as a hotspot with regard to peptide neurotoxicity. We introduce an approach to ...
Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75 [0.03%]
C75脂肪酸合酶抑制剂对映体的放射增敏潜能差异性研究
Colin Rae,John W Babich,Robert J Mairs
Colin Rae
The elevated activity of fatty acid synthase has been reported in a number of cancer types. Inhibition of this enzyme has been demonstrated to induce cancer cell death and reduce tumor growth. In addition, the fatty acid synthase inhibitor ...
A convenient and validated enantiomer separation of chiral aliphatic amines as nitrobenzoxadiazole derivatives on polysaccharide-derived chiral stationary phases under simultaneous ultraviolet and fluorescence detection [0.03%]
一种手性多糖柱拆分茋衍生的亚胺基茋
Suraj Adhikari,Jong Seong Kang,Wonjae Lee
Suraj Adhikari
A convenient method using a fluorogenic agent, 4-chloro-7-nitro-1,2,3-benzoxadiazole (NBD-Cl), was developed for enantiomer separation of chiral aliphatic amines including amino alcohols by normal high-performance liquid chromatography. The...