Resolution, determination of enantiomeric purity and chiral recognition mechanism of new xanthone derivatives on (S,S)-whelk-O1 stationary phase [0.03%]
（SS）-whelk-o1手性固定相拆分新型木兰花属黄烷酮类衍生物及其对映体纯度测定和手性识别机理研究
Maria L Carraro,Andreia Palmeira,Maria E Tiritan et al.
Maria L Carraro et al.
The enantioresolution and determination of the enantiomeric purity of 32 new xanthone derivatives, synthesized in enantiomerically pure form, were investigated on (S,S)-Whelk-O1 chiral stationary phase (CSP). Enantioselectivity and resoluti...
Factors screening to statistical experimental design of racemic atenolol kinetic resolution via transesterification reaction in organic solvent using free Pseudomonas fluorescens lipase [0.03%]
通过有机溶剂中自由荧光假单胞菌脂肪酶介导的转酯化反应筛选 rac-阿替洛尔动力学拆分的统计实验设计因素
Joni Agustian,Azlina Harun Kamaruddin,Hassan Y Aboul-Enein
Joni Agustian
As the (R)-enantiomer of racemic atenolol has no β-blocking activity and no lack of side effects, switching from the racemate to the (S)-atenolol is more favorable. Transesterification of racemic atenolol using free enzymes investigated as...
Determination of the enantiomeric purity of the selective dopamine transporter inhibitor (+)-R,R-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [0.03%]
测定选择性多巴胺转运蛋白抑制剂(+)-R,R-4-(2-苯并二氢吡咯乙基)-1-(4-氟苯基)丙醇的对映体纯度
Patrick Neiens,Georg Höfner,Klaus T Wanner
Patrick Neiens
(+)-R,R-D-84 ((+)-R,R-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol) is a promising pharmacological tool for the dopamine transporter (DAT), due to its high affinity and selectivity for this target. In this study, an analytical ...
Enantioselective potential of polysaccharide-based chiral stationary phases in supercritical fluid chromatography [0.03%]
基于多糖手性固定相的超临界流体色谱法的手性选择性能研究
Gabriela Kucerova,Kveta Kalikova,Eva Tesarova
Gabriela Kucerova
The enantioselective potential of two polysaccharide-based chiral stationary phases for analysis of chiral structurally diverse biologically active compounds was evaluated in supercritical fluid chromatography using a set of 52 analytes. Th...
Synthesis of l-threitol-based crown ethers and their application as enantioselective phase transfer catalyst in Michael additions [0.03%]
基于l-苏糖醇的冠醚合成及其在迈克尔加成反应中手性相转移催化作用的研究
Zsolt Rapi,Tamás Nemcsok,Ádám Pálvölgyi et al.
Zsolt Rapi et al.
A few new l-threitol-based lariat ethers incorporating a monoaza-15-crown-5 unit were synthesized starting from diethyl l-tartrate. These macrocycles were used as phase transfer catalysts in asymmetric Michael addition reactions under mild ...
Enantioselective synthesis of (S)-naproxen using immobilized lipase on chitosan beads [0.03%]
固定化脂酶手性合成萘普生左旋体(S)-Naproxen的研究
Saeedeh L Gilani,Ghasem D Najafpour,Hamid D Heydarzadeh et al.
Saeedeh L Gilani et al.
S-naproxen by enantioselective hydrolysis of racemic naproxen methyl ester was produced using immobilized lipase. The lipase enzyme was immobilized on chitosan beads, activated chitosan beads by glutaraldehyde, and Amberlite XAD7. In order ...
LC-MS/MS and chiroptical spectroscopic analyses of multidimensional metabolic systems of chiral thalidomide and its derivatives [0.03%]
手性反应系统的高效液相色谱-串联质谱和旋光色谱联用分析及其衍生物代谢产物的手性分离与鉴定
Yoshiyuki Ogino,Masahito Tanaka,Togo Shimozawa et al.
Yoshiyuki Ogino et al.
Enantiomeric thalidomide undergoes various kinds of biotransformations including chiral inversion, hydrolysis, and enzymatic oxidation, which results in several metabolites, thereby adding to the complexity in the understanding of the natur...
Liquid and subcritical fluid chromatographic enantioseparation of Nα -Fmoc proteinogenic amino acids on Quinidine-based zwitterionic and anion-exchanger type chiral stationary phases. A comparative study [0.03%]
基于奎尼丁的手性固定相的液相色谱和亚临界流体色谱法拆分Nα-Fmoc氨基酸蛋白质合成单元的对映异构体：比较研究
Gyula Lajkó,Nóra Grecsó,Gábor Tóth et al.
Gyula Lajkó et al.
Stereoselective high-performance liquid chromatographic and subcritical fluid chromatographic separations of 19 Nα -Fmoc proteinogenic amino acid enantiomers were carried out by using Quinidine-based zwitterionic and anion-exchanger-type c...
Comparative Study
Chirality. 2017 Jun;29(6):225-238. DOI:10.1002/chir.22700 2017
Optical resolution and mechanism using enantioselective cellulose, sodium alginate and hydroxypropyl-β-cyclodextrin membranes [0.03%]
基于手性纤维素、藻酸钠及羟丙基-β-环糊精的手性选择性光学解析及其机理研究
Li-Ming Yuan,Wei Ma,Mei Xu et al.
Li-Ming Yuan et al.
Chiral solid membranes of cellulose, sodium alginate, and hydroxypropyl-β-cyclodextrin were prepared for chiral dialysis separations. After optimizing the membrane material concentrations, the membrane preparation conditions and the feed c...
Impact of microorganisms, humidity, and temperature on the enantioselective degradation of imazethapyr in two soils [0.03%]
微生物、湿度和温度对两种土壤中手性除草剂_imazethapyr_消旋化的影晌
Hao Wu,Xiaolin He,Huifen Dong et al.
Hao Wu et al.
Imazethapyr (IM) is a chiral herbicide composed of an (-)-R-enantiomer and an (+)-S-enantiomer with differential herbicidal activity. In this study, the effects of microbial organisms, humidity, and temperature on the selective degradation ...