Chiral Separation and Molecular Simulation of Five Quinolones on a Bonded Amylose[(S)-α-Methylbenzyl Carbamate] Column (CHIRALPAK IH) and the Elucidation of Its Recognition Mechanism [0.03%]
手性柱IH拆分五元环喹诺酮及其分子模拟研究与识别机理探讨
Xiangwen Chen,Xuan Chen,Juan Pan et al.
Xiangwen Chen et al.
In this work, the silica gel bonded amylose[(S)-α-methylbenzyl carbamate] (CHIRALPAK IH) was chosen as the chiral stationary phase (CSP) for the separation of five quinolone enantiomers by high-performance liquid chromatography (HPLC), nam...
Chiral Post-Modification of UiO-66-NH2 on Gas Chromatography Chiral Separation [0.03%]
UiO-66-NH2固相衍生化手性分离材料的制备及其在气相色谱中的应用研究
Jia Huang,Yizhuo Ma,Maria Abbasi et al.
Jia Huang et al.
As enantiomers can have different pharmacological and toxicological impacts even though they have the analogous chemical composition, efficient chiral separation is crucial. Chromatography is one of the primary methods for separating enanti...
Stokes Spectropolarimetry Applied to Measure Circular Birefringence Dispersion of Aqueous Solutions of Sugars [0.03%]
用于测量糖水溶液圆偏振色散的 Stokes 谱偏振光度法
Ruan Lucas Sousa Lima,Eric Santos da Silva,Paulo Trindade Araujo et al.
Ruan Lucas Sousa Lima et al.
Circular birefringence (CB) is defined as the difference in refractive index for opposite circular polarization states and has played a crucial role in the development of stereochemistry and the concept of chirality. It manifests experiment...
Electrochemiluminescent Chiral Sensor Based on Covalent Organic Frameworks for Discrimination of Phenylalanine Enantiomers [0.03%]
一种手性电致化学发光传感器用于识别苯甘氨酸对映体
Qinhua Liu,Xuan Kuang
Qinhua Liu
Chiral recognition of amino acids is crucial in pharmaceutical and clinical fields due to the enantiomer-dependent bioactivity of chiral compounds. Here, we report an electrochemiluminescent (ECL) sensor utilizing a chiral covalent organic ...
Automated Evaluation Method for Aggregation-Induced Circularly Polarized Luminescence of Platinum(II) Complexes With 1,1'-Bi-2-naphthol Derivatives as Ligands [0.03%]
基于1,1'-.bi-2-萘酚衍生物配体的铂(ii)配合物聚集诱导圆偏振发光的自动化评价方法
Satoko Suzuki,Akio Kaneta,Anas Santria et al.
Satoko Suzuki et al.
Luminogens exhibiting aggregation-induced circularly polarized luminescence (AICPL) properties have garnered significant attention in recent years due to their promising applications in optoelectronics and biomedical research. Typically, ag...
The Reversible Dimerization of Chiral Ureidopyrimidinones. Chiroptical Signaling via the Formation and Disruption of Quadruple Hydrogen Bonding Arrays [0.03%]
手性脲嘧啶
Gary D Jaycox
Gary D Jaycox
In solution, 2-ureido-4[1H]-pyrimidinones show a strong propensity to dimerize via a well-defined quadruple donor-donor-acceptor-acceptor hydrogen bonding array. For derivatives that have been modified with chiral functional groups, intermo...
Chiral Ionic Liquids for Enantioselective Liquid-Liquid Extraction of DL-3-Phenyllactic Acid: Synthesis, Characterization, and Mechanistic Insights [0.03%]
用于DL-3-苯基乳酸对映体分离的拆分性离子液体的设计合成及其机制研究
Min Wei,Yinxin Yang,Ruoxi Huang et al.
Min Wei et al.
In this work, a novel pair of chiral ionic liquids (CILs) based on cis- and trans-myrtanol was designed, synthesized, and applied in the enantioselective liquid-liquid extraction (LLE) of DL-3-phenyllactic acid (DL-3-PLA). DL-3-PLA, a natur...
Synthesis, Conformational Analysis, Antioxidant and Enzyme Inhibition Activity, Molecular Docking, and DFT Studies of New Chiral Hydrazide-Hydrazone Derivatives [0.03%]
新的手性腙衍生物的合成、构象分析、抗氧化及酶抑制活性、分子对接和DFT研究
Şenel Teke Tunçel,Yusuf Sıcak,M Oluş Özbek et al.
Şenel Teke Tunçel et al.
A new series of chiral hydrazide-hydrazone derivatives were synthesized and evaluated their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase and urease inhibition and antioxidant activities. The chemical structures of n...
Molecular Docking Observations on Enantiomeric Retention Trends and Selection of Chiral Stationary Phase [0.03%]
对映体保留趋势的分子对接观察及手性固定相的选择
Anca-Elena Dascălu,Alina Ghinet,Eric Boulanger et al.
Anca-Elena Dascălu et al.
This study explores molecular docking as a predictive tool for enantiomeric separations in supercritical fluid chromatography, focusing on the binding mechanisms of chiral stationary phases. The enantiomeric separation of five chiral molecu...
Quantitative Chiral Separations on KRAS Inhibitor Sotorasib by UHPLC-MS/MS: Method Validation and Enantioselective Pharmacokinetics Assessment in Rat Plasma [0.03%]
基于UHPLC-MS/MS的KRAS抑制剂Sotorasib的手性定量分离：方法验证及其在大鼠血浆中的对映体选择性药代动力学评估
Jony Susanna Kandula,Keyur Parmar,A R Priyadharshni et al.
Jony Susanna Kandula et al.
In this research, estimation of enantioselective pharmacokinetics and biological interconversion of sotorasib were investigated. This is the first report for the novel chiral liquid chromatography-tandem mass spectrometry method for the ena...