Evaluation of the Alkaloid Secretions within the Millipede Brachycybe and Their Pheromone Properties [0.03%]
球足目线千足虫属种体内生物碱成分分析及其信息素功能研究
Arden Hatch,Anne C Jones,Luisa F Vasquez-Valverde et al.
Arden Hatch et al.
Brachycybe is a genus of the millipede subterclass Colobognatha, a group that exhibits rare social characteristics, including species aggregations and male brood care. Although it has been hypothesized that alkaloid-based defensive secretio...
Diacarnusins A-F, nor-Terpene Endoperoxides of the Red Sea Sponge Diacarnus erythraeanus [0.03%]
来自红海海绵Diacarnus erythraeanus的角甲素A-F：nor倍半萜内过氧化物类化合物
Rania Hasib Afana,Lilach Raijman-Nagar,Micha Ilan et al.
Rania Hasib Afana et al.
Six new nor-terpene endoperoxides, diacarnusins A-F (1-6), along with five known ones (7-11), were isolated from the extract of the Red Sea sponge Diacarnus erythraeanus, which presented cytotoxic activity against the colon carcinoma cell l...
Regulator-Guided Strain Prioritization and Genome Engineering Uncovers Concanamycin Analogs [0.03%]
基于调节因子的菌株筛选及基因组编辑发现康cal抗生素新衍生物
Linnea Verhey-Henke,Katherine L Lev,Morgan McCauley et al.
Linnea Verhey-Henke et al.
Bafilomycin and concanamycin analogs (1-3) are microbial natural products with potent V-ATPase inhibitory activity. Despite their promising therapeutic potential, limited access to these plecomacrolide scaffolds has constrained their broade...
Persenone A from Avocados Exhibits Potent Anti-Fungal Activity against Coccidioides [0.03%]
鳄梨中的Persenone A 对于 Cocci 病原真菌具有强力的抗真菌活性
Vladimir Maslivetc,Susana Tejeda-Garibay,Adeola Fagbayibo et al.
Vladimir Maslivetc et al.
Coccidioidomycosis, or Valley fever, is a fungal respiratory disease caused by Coccidioides immitis or Coccidioides posadasii. Clinical manifestations range from asymptomatic infection to chronic pulmonary disease. Despite the increasing en...
Structural Insights into Metal-Chelating Natural Inhibitors of Factor Inhibiting HIF-1α [0.03%]
金属螯合天然抑制剂因子抑制HIF-1α的结构洞察
Yochidamai Akhsanitaqwim,Yu Nakashima,Naotaka Ikumi et al.
Yochidamai Akhsanitaqwim et al.
Factor inhibiting HIF-1α (FIH) is a 2-oxoglutarate-dependent oxygenase that controls hypoxia signaling and metabolic homeostasis by hydroxylating HIF-1α. Although selective pharmacological inhibition of FIH represents an emerging therapeu...
Phenolmacrolide A, a Benzenoid Ansamycin from Marine-Derived Streptomyces olivaceus NBUA17 with In Vitro Antipancreatic Cancer Activity, Targets EEF1A2 [0.03%]
来源于海洋微生物链霉菌的苯并安桑霉素抗胰腺癌活性成分酚大环内酯A靶向EEF1A2蛋白质
Fangjian Feng,Ran Wang,Zhiran Ju et al.
Fangjian Feng et al.
Ansamycins with diverse ring systems play an indispensable role in the pharmaceutical industry. A novel 20-membered ester-incorporating benzenoid ansamycin, phenolmacrolide A (1), and a new naphthalenoid ansamycin, olimycin I (2), were obta...
Nigroepocins A-D: Antifungal Polyketides from Nigrospora sp. SN56127 with Activity against Fusarium graminearum [0.03%]
来自SN56127 Nigrospora菌的抗真菌多肽类化合物Nigroepocins A-D对Fusarium graminearum具有活性
Shijun Zhong,Jiajun Chen,Huiyuan Yu et al.
Shijun Zhong et al.
Nigroepocins A-D (1-4), along with one known compound clavatol (5), were isolated from the fermentation broth of Nigrospora sp. SN56127. Their structures, including absolute configurations, were determined by NMR, MS, and single-crystal X-r...
Correction to "Tepuazines A-E: Phenazine Glycosides from a Venezuelan Quartz-Rich (Tepui) Cave Soil-Derived Streptomyces virginiae CMB-CA091" [0.03%]
关于“来自委内瑞拉富石洞土衍生链霉菌品系的Tepuazines A-E：phenazine糖苷”的勘误公告
Sarani Kankanamge,Zeinab G Khalil,Robert J Capon
Sarani Kankanamge
Published Erratum
Journal of natural products. 2026 Jul 13. DOI:10.1021/acs.jnatprod.6c00728 2026
4-Acyl-5-aminoimidazole Alkaloids from a Marine-Derived Streptomyces sp. OUCMDZ-944 [0.03%]
海洋链霉菌OUCMDZ-944产生的4-酰基-5-氨基咪唑类生物碱
Yue Liu,Bowei Wen,Guoliang Zhu et al.
Yue Liu et al.
Thirteen new 4-acyl-5-amino-1H-imidazole alkaloids (1-13) were identified from cultures produced by the marine-derived Streptomyces sp. OUCMDZ-944 using feature-based molecular networking (FBMN)-guided isolation. Notably, compounds 1 and 2 ...
Craterstatins A-D: Terpenyl- p-aminobenzoic Acids Produced by an Australian Pasture Soil-Derived Streptomyces sp [0.03%]
来自澳大利亚牧场土壤中链霉菌产生的内酯型聚酮大环化合物：CraterstatinsA-D
Shengbin Jin,David F Bruhn,Erica Burkman et al.
Shengbin Jin et al.
An investigation into Australian pasture soil-derived microbes led to the prioritization of Streptomyces sp. S4S-00182A09 due to the media extract ability to inhibit the motility of dog heartworm Dirofilaria immitis microfilariae (Mf), and ...