Clinical Translation Considerations for Diacerein-Loaded Oleoliposome Dry-Powder Inhalation in COPD [0.03%]
用于慢性阻塞性肺疾病患者的载有二月桂酸二硬脂基瓜尔胶的油质脂质体干粉吸入制剂的临床转化注意事项
Devendra Kumar Singh,Thakur Rohit Singh,Varshini Vadhithala et al.
Devendra Kumar Singh et al.
Specific polysorbate fingerprints of CHO hydrolases and implications for indirect assays [0.03%]
CHO 水解酶的特定聚山梨酯指纹及其对间接测定方法的影响
Melanie Maier,Viktor Gross,Linus Weiss et al.
Melanie Maier et al.
Polysorbate degradation in biopharmaceutical formulations can impact the stability and efficacy of therapeutic proteins. This degradation is predominantly caused by specific residual host cell hydrolases present at sub-ppm concentrations. T...
An alternative nonclinical approach to support the first-in-human clinical trial of a T-cell bispecific targeting EGFRvIII [0.03%]
支持针对EGFRv III的T细胞双特异性抗体首次用于人体试验的非临床研究的替代方法
Elisabeth Husar,Silke Simon,Afsaneh Abdolzade-Bavil et al.
Elisabeth Husar et al.
As a tumor specific protein, EGFRvIII represents an ideal target for targeted cancer immunotherapies. Here we report the nonclinical evaluation of EGFRvIII-TCB, a novel EGFRvIII-targeted T-cell bispecific antibody designed for glioblastoma ...
Modeling Filtration Flow Rate in Peristaltic Pump Systems for High-Viscosity Bovine Serum Albumin: A Multivariate Nonlinear Approach [0.03%]
基于多元非线性方法的牛血清白蛋白高粘度溶液蠕动泵系统过滤流速模型研究
Jianwei Chang,Yu Zhang,Fang Zhang et al.
Jianwei Chang et al.
Filtration of highly viscous pharmaceutical solutions exhibits a non-linear relationship between pump speed and flow rate. To systematically investigate this phenomenon, experiments were conducted across a wide range of solution viscosities...
Development and evaluation of high-flowability spherical crystals of tofacitinib citrate Form A for direct powder compression [0.03%]
左旋氨氯地平A型高流动性球晶的制备及直接压片性能评估
Xueyao Zeng,Xiao Ke,Xinnuo Xiong et al.
Xueyao Zeng et al.
A novel method for preparing spherical crystals of tofacitinib citrate Form A is presented in this study, alongside the determination of its single-crystal structure. Tofacitinib citrate was dissolved in a ternary solvent system of two alco...
Paper-Based Reaction Devices as Accelerated Platforms in Forced Degradation Studies [0.03%]
基于纸张的反应装置作为强制降解研究中的加速平台
Airton G Salles Jr,Willian R de Araujo,Manoel T Rodrigues Jr et al.
Airton G Salles Jr et al.
The stability of pharmaceutical compounds is a central concern in drug development, as degradation can compromise both efficacy and safety. Conventional forced degradation studies, while effective, are often time-consuming and resource-inte...
Development of HRP-based 3D intercellular exchange assay for high throughput screening [0.03%]
基于HRP的高通量筛选三维细胞间交换测定法的发展
Xian Wu,Xiangxiang Hu,Yiqin Li et al.
Xian Wu et al.
Extracellular vesicles (EVs) play a vital role in mediating intercellular communication and regulatory processes. Using a three-dimensional (3D) intercellular exchange assay, we previously demonstrated that EVs facilitate the intercellular ...
Investigating the effect of solvent polarity environment differences in electrolyte and non-electrolyte systems [0.03%]
溶剂极性环境差异在电解质和非电解质体系中的影响研究
Valeria Briceida Tellez-Gallego,Kate Sorg,Rodolfo Pinal
Valeria Briceida Tellez-Gallego
To address the knowledge gap regarding the polarity of excipient solutions and the impact on biologically relevant systems, a comprehensive exploration of the polarity of solutions is essential. This study explores the solvatochromic respon...
Diffusional release of a dispersed solute from solid and hollow cylindrical polymeric matrix into a finite external volume [0.03%]
有限外部体积中固态和空心圆柱形聚合物基质中分散溶质的扩散释放
Mahdi Cheraghian,Mohammad J Abdekhodaie
Mahdi Cheraghian
This study proposes both exact and numerical methodologies to characterize the diffusional release kinetics of a solute from solid or hollow cylindrical polymeric matrices into a limited external environment when the initial solute concentr...
The Crux of vehicle designations: The essence of topical dermatologic vehicles and their use [0.03%]
车辆设计的实质：皮肤局部用药载体的真谛及其应用
Christian Surber,Michael E Herbig,Daphne Reinau-Häberlin
Christian Surber
Topical therapies are essential in dermatology, accounting for over half of all prescriptions. These treatments are invaluable for managing various skin conditions due to their localized effect, ease of access and application, and generally...