Excipient substitution in botulinum toxin type A formulations: Insights from multi-scale in silico modelling [0.03%]
肉毒杆菌A型制剂中辅料替代:来自多尺度计算模型的见解
Eqram Rahman,Alain Michon,Parinitha Rao et al.
Eqram Rahman et al.
Botulinum neurotoxin type A (BoNT/A) formulations differ mainly in excipients, which determine stability, aggregation, and diffusion. Using multi-scale in silico modelling (AesthetiSIMTM), we evaluated excipient substitution across six mark...
Modeling and simulation of Benzimidazole dissolution behavior in different monosolvents using machine learning and thermodynamic models [0.03%]
基于机器学习和热力学模型模拟苯并咪唑在不同单一溶剂中溶解行为及其机理研究
Kassem Al Attabi,Farag M A Altalbawy,Deepak J et al.
Kassem Al Attabi et al.
Benzimidazole, a compound valued for its distinct physicochemical characteristics and diverse applications, is the focus of this investigation into its dissolution behavior across various monosolvents. This research employs sophisticated ma...
Kenneth L Audus
Kenneth L Audus
2026 Scientific Advisors to the Editors (SAEs) Appointments and Updates [0.03%]
2026年编辑部科学顾问(SAEs)任命及更新
Kenneth L Audus
Kenneth L Audus
Sesquiterpenes from galangal essential oil as potent penetration enhancer: Effect on stratum corneum components and cutaneous TRPV4 ion channel [0.03%]
姜黄挥发油中的倍半萜作为强透皮吸收促进剂:对角质层成分和皮肤瞬时受体电位香草酸亚型4离子通道的影响
Tianyu He,Rong Tian,Zhichao Song et al.
Tianyu He et al.
Natural terpenes found in essential oils (EOs) have shown promise as penetration enhancers (PEs) in pharmaceutical and cosmetic formulations. This study compared the skin penetration enhancement properties of sesquiterpenes and monoterpenes...
Response to Comments on "Diacerein-Loaded Oleoliposome Dry-Powder Inhalation Nano-Formulation for COPD" [0.03%]
关于“用于COPD的载有多硫酸软骨素的油质脂质体干粉吸入纳米制剂”的讨论答复论文
Ossama M Sayed,Khaled Almansour,Amira A Boseila et al.
Ossama M Sayed et al.
Kenneth L Audus
Kenneth L Audus
Ensuring pharmaceutical safety: Highthroughput LC-MS/MS method for plastic additive detection [0.03%]
确保药物安全性:塑料添加剂检测的高通量LC-MS/MS方法
İbrahim Hakkı Demircioğlu,Oğuzhan Dalkılıç,Saffet Çelik et al.
İbrahim Hakkı Demircioğlu et al.
Extractables and Leachables studies require highly reliable and sensitive analytical methods to ensure pharmaceutical product safety. Plastic additives are widely used during production to improve the physicochemical properties of polymeric...
Russell O Potts
Russell O Potts
A review of the Potts-Guy equation and its impact on drug delivery. Keywords: PhD; Russell O. Potts. ...
When heat strikes: Investigating unexpected particles in sodium bicarbonate injections [0.03%]
热效应:调查碳酸氢钠注射液中的意外粒子事件
Narasimha Swamy Kollu,Ravikiran Allada
Narasimha Swamy Kollu
The presence of particles in injectable formulations presents significant risks, such as embolism, phlebitis, and thrombophlebitis. Moreover, visible particles violate pharmacopeial standards and may lead to regulatory actions. Therefore, i...