Development of a mechanistic in vitro-in vivo correlation for upadacitinib using physiologically-based pharmacokinetic modeling [0.03%]
基于生理的药代动力学模型的乌帕替尼机理体内体外关联的发展研究
Md Mahbubul Huq Riad,Sumit Bhatnagar,Susan George et al.
Md Mahbubul Huq Riad et al.
A physiologically-based pharmacokinetic (PBPK) model was successfully developed to describe the absorption, distribution, metabolism, and excretion processes for the upadacitinib 15 mg, 30 mg, and 45 mg extended-release (ER) formulations. A...
Enhanced antifungal therapy for cutaneous candidiasis: Development, evaluation, and optimization of luliconazole-loaded transethosomal gel [0.03%]
用于皮肤念珠菌病的改良抗真菌疗法： luliconazole载药转移脂质体凝胶的研发、评估及优化
Mohamed A Akl,Mahmoud M El-Sonbaty,Tarek M Ibrahim et al.
Mohamed A Akl et al.
Cutaneous Candidiasis, a widespread opportunistic fungal infection primarily caused by Candida albicans, accounts for 1% of outpatient and 7% of inpatient dermatology consultations. The rise in antifungal resistance due to genetic mutations...
Changing the container closure system of lyophilized products: Real or perceived risk to process efficiency and product quality? [0.03%]
影响冻干产品的容器密封系统变更：对工艺效率和产品质量的真正风险还是感知到的风险？
Maxwell Korang-Yeboah,Ann-Marie Afrifa,Lisa Ma et al.
Maxwell Korang-Yeboah et al.
The container-closure system (CCS), specifically the glass vial, plays a pivotal role in heat transfer during lyophilization, thereby influencing process efficiency and product quality. Therefore, a change in CCS without corresponding chang...
Mechanistic insights into drug loading effect on dissolution performance of Loratadine-Soluplus® amorphous solid dispersions [0.03%]
洛拉替丁-索鲁普卢斯无定型固体分散体中载药量对药物溶出性能影响的机制研究
Jannat Falah Hassan,Kawther Khalid Ahmed,Tze Ning Hiew
Jannat Falah Hassan
Amorphous solid dispersions (ASDs) hold promising potential towards modulating the solubility of poorly soluble drugs. However, their use is limited by poor understanding of release mechanism and kinetics, especially with Soluplus®. In thi...
Reply to Maboudi's Comment on "Formulation and In Vitro Evaluation of Liposomal and SMEDDS-Based Cannabidiol Delivery Systems" [0.03%]
对Maboudi关于“大麻二酚脂质体和SMEDDS递送系统的设计与体外评价”的评论的回复
Chrystalla Protopapa,Ioannis Tsichlis,Siva Satyanarayana Kolipaka et al.
Chrystalla Protopapa et al.
Investigation on the antitumor and antibacterial performance of photothermally active molybdenum oxide materials [0.03%]
具有光热活性的钼氧化物材料的抗肿瘤和抗菌性能研究
Hongmei Bai,Ping Zhang,Shihai Chen et al.
Hongmei Bai et al.
Post-surgical breast cancer management remains limited by systemic toxicity, residual tumor burden, and infection risk. To address these issues, we developed an intelligent nanoplatform (MoOx@DOX@LNT) for the co-delivery of oxygen-deficient...
Quantitative prediction of human metabolites formed from the oxidation of the alcohol group of the glucokinase activator, TMG-123, using chimeric mice with humanized livers [0.03%]
TMG-123（一种糖激酶激活剂）的人体代谢物定量预测及其氧化反应研究（利用肝脏人类化嵌合小鼠）
Akiko Watanabe,Seishiro Sakamoto,Shigeru Ohta et al.
Akiko Watanabe et al.
Pharmacokinetic (PK) predictions in humans are important for both the parent compounds and their metabolites, as these predictions help decide whether to progress to human clinical trials. More human PK prediction studies have been conducte...
Sericin and alginate loaded nanocomposite hydrogels for encapsulation and oral administration of insulin [0.03%]
丝素和海藻酸盐负载纳米复合水凝胶用于胰岛素的封装及口服给药
Sania Faiz,Hafiz Muhammad Tahir,Rida Mahnoor et al.
Sania Faiz et al.
Diabetes mellitus is a major global health concern, with limited progress in the development of efficient oral insulin formulations. The current study was designed to assess the physicochemical, biochemical, and therapeutic efficiency of al...
Promising purine-silver nanoparticles for tumor theranostic: Synthesis, radiolabeling, in vitro cytotoxicity, structure-activity relationship, and in vivo biodistribution studies [0.03%]
具有治疗诊断潜力的嘌呤-银纳米颗粒：合成，放射标记，体外细胞毒性，构效关系及体内生物分布研究
Hesham A Shamsel-Din,Ahmed B Ibrahim
Hesham A Shamsel-Din
Purine derivatives are valuable anticancer agents, but their limited stability and poor tumor selectivity restrict therapeutic efficacy. This study aimed to overcome these barriers by designing a multifunctional radiotheranostic system inte...