Challenges in surfactant removal from biopharmaceutical formulations using TFF and spin columns [0.03%]
使用TFF和旋转柱从生物制药配方中去除表面活性剂的挑战
Kristian Le Vay,Benjamin Steinborn,Constanze Helbig et al.
Kristian Le Vay et al.
Surfactants such as polysorbate 20 (PS20), polysorbate 80 (PS80), and poloxamer 188 (P188) are integral to the stabilization of protein therapeutics, yet their removal is often required during formulation development and analytical characte...
Large language models in drug delivery: A review of the current landscape and future perspectives [0.03%]
大型语言模型在药物递送中的应用：当前格局与未来展望综述
Molham Sakkal,Abdallah Abou Hajal
Molham Sakkal
The development of effective drug delivery systems (DDS) faces persistent challenges, including biological barriers, formulation stability, low bioavailability, and complex regulatory demands. While artificial intelligence (AI) and machine ...
New method for adsorbing the pharmaceuticals on mesoporous silica: Adsorption behavior of ibuprofen on mesoporous silica via the sealed and heating method [0.03%]
一种新的药物在介孔二氧化硅材料上吸附的方法及布洛芬在此类材料上的密封加热吸附行为研究
Yayoi Kawano,Kazuya Nomura,Nobuyuki Natori et al.
Yayoi Kawano et al.
Many active pharmaceutical ingredients (APIs) currently being developed are poorly soluble in water, which enhances their solubility and bioavailability critical challenges. The evaporation/condensation (EV) method, wherein crystalline APIs...
Forging certainty: A novel framework for the specification of combination products [0.03%]
打造确定性：关于组合产品的规范的新框架
Rafeek F Shokry
Rafeek F Shokry
The specification for a combination product represents a critical covenant of its quality. Too often, the current intellectual framework for forging this covenant remains a fragmented patchwork of legacy pharmaceutical and medical device pa...
Dermal disposition characterization and development of a retrospective level A in vitro-in vivo relationship for topical metronidazole products [0.03%]
甲硝唑外用产品的皮质分布特征及回顾性水平A体外-体内关系模型的建立
Benjamin A Kuzma,Sharareh Senemar,Tannaz Ramezanli et al.
Benjamin A Kuzma et al.
Dermal microdialysis involves the insertion of a probe into the dermis beneath an application site for a topical drug product (TDP). The probe measures local, unbound, active pharmaceutical ingredient (API or drug) concentrations in the der...
An integrated material-sparing method for determining dilution potential of direct compression tablet fillers [0.03%]
一种用于确定直接压缩法制剂稀释潜力的集约化材料节约方法
Weeraya Tharanon,Yiwang Guo,Jomjai Peerapattana et al.
Weeraya Tharanon et al.
An ideal filler for direct compression (DC) formulation requires both good flowability and compactibility. To ensure consistent tablet quality across various APIs and API loadings, as well as successful manufacturability, it is essential to...
Temperature-dependent colloidal behavior of polymer-stabilized gold nanoparticles [0.03%]
聚合物稳定金纳米颗粒的温度依赖胶体行为研究
Amit K Barui,Tori Leyba,Rachel Edwards et al.
Amit K Barui et al.
Polymer-based composites, like polystyrene-gold nanoparticles (PS-AuNPs) are widely used in pharmaceutical and biomedical applications including targeted drug delivery, imaging, biosensing, and photothermal due to their combined plasmonic a...
Can an absorptive sink improve the predictivity of biomimetic two-stage dissolution testing: Comparative IVIVC of various formulations of the poorly soluble drug emodepside [0.03%]
吸收池能否改善生物模仿两步溶出测试的预测性：对比评价不同原料药艾莫德普斯特的体内外相关性
Jakob Tobias Lynnerup,Tim Lillotte,Dennis Oversohl et al.
Jakob Tobias Lynnerup et al.
Drug release from four different formulations of the poorly soluble drug emodepside was determined in absence and presence of an absorptive sink (absorptive compartment separated by a barrier) by analyzing both molecularly dissolved and app...
Augmenting the cytotoxicity and apoptosis induction of green synthesized copper oxide nanoparticles from Artemisia sieberi by combining with tamoxifen: Mechanism involving Bax/Bcl-2 modulation [0.03%]
结合他莫昔芬增强小花龙胆绿色合成的铜氧化学疗法和促凋亡作用：通过调节Bax/Bcl-2实现
Saeed Seghatoleslami,Mohammadreza Pourmohammad,Homa Mahmoudzadeh et al.
Saeed Seghatoleslami et al.
Treatment of breast cancer is severely hindered by dose-limiting toxicity and acquired Tamoxifen (Tam) resistance. This study investigated the synergistic anti-cancer effect and molecular mechanism of green-synthesized Copper Oxide Nanopart...
A pharmaceutical developability perspective on antibodies with ultra-long CDRs [0.03%]
具有超长CDR的抗体的药物开发观点
Marcel Passon,Stefaan De Smedt,Hristo L Svilenov
Marcel Passon
Antibodies with ultralong complementarity-determining regions (ulCDRs) have unique antigen-binding features with considerable potential for biomedical applications. Despite this potential, their stability and developability remain largely u...