Development and characterization of allopurinol-loaded transethosomal gel for topical gout management [0.03%]
一种外用治疗痛风的别嘌醇载药透乙osomes凝胶的开发与表征
Iqra Safdar,Aqeedat Javed,Muhammad Usman et al.
Iqra Safdar et al.
Gout refers to the painful inflammation of the joints due to deposition of monosodium urate (MSU) cystals. Treatment of gout commonly involve a biopharmaceutical classification system (BCS) class IV drug, allopurinol (ALLP), which is a xant...
Biopolymer-stabilized zein nanoparticles for pressure ulcer management: Formulation, optimization, and preliminary in vivo assessment [0.03%]
用于压力性溃疡管理的生物聚合物稳定玉米谷蛋白纳米颗粒：配方、优化及初步体内评估
Yasmin E Emara,Wessam M El-Refaie,Maram M Allam et al.
Yasmin E Emara et al.
Pressure ulcers (PUs) remain a major healthcare burden, requiring innovative, safe, and effective therapies. Bioactive polysaccharide-based nanoplatforms offer promise owing to their biocompatibility, biodegradability, and wound-healing pot...
A novel in silico platform combining data-driven and physics-based models for protein formulation developability assessment [0.03%]
一种新型计算平台结合数据驱动和物理基础模型用于蛋白质配方开发性评估
Andrea Arsiccio,Kristian Le Vay,Andre Sao Pedro et al.
Andrea Arsiccio et al.
The development of novel therapeutic proteins is accompanied by huge financial and time investments. Advancing molecules through drug product development without proper scrutiny often leads to costly failures. In some cases, such failures a...
Cinnamon oil-driven lipid nanocarrier system for topical miconazole delivery: QbD-based development and characterization [0.03%]
基于QbD的脂质纳米载体系统用于局部递送麦珠子灰浆的肉桂油驱动研究与表征
Sarah I Bukhari,Rama Kharsa,Munirah Al Otaibi et al.
Sarah I Bukhari et al.
Lipid-based nanocarriers offer a promising approach to provide topical antifungal therapy through drug delivery enhancement and synergistic effect. Accordingly, the study was planned to develop a nano-lipid matrix incorporating an antifunga...
Impact of disintegrants on the structure and disintegration of hydroxypropyl methylcellulose-based amorphous solid dispersion tablets [0.03%]
崩解剂对羟丙甲纤维素共熔物无定型固体分散体制剂结构和溶出性能的影响研究
Natsuki Takahashi,Miho Inoue,Takayuki Terukina et al.
Natsuki Takahashi et al.
Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration delay after storage poses a significant challenge to formulation performance. This study investig...
Prediction of vancomycin exposure in patients with central nervous system infections using physiologically based pharmacokinetic modeling [0.03%]
基于生理的药代动力学模型在中枢神经系统感染患者万古霉素暴露量预测中的应用
Ya-Xin Liu,Yun Kuang,Jin-Long Liu et al.
Ya-Xin Liu et al.
Vancomycin remains a key therapeutic option for central nervous system (CNS) infections caused by Gram-positive bacteria, yet its limited and variable penetration into the cerebrospinal fluid (CSF) poses challenges for optimal dosing. This ...
Advantages and limitations of the inclusion of ascorbic acid on nitrosamine mitigation in pharmaceutical drug products [0.03%]
维生素C在药物产品中抑制亚硝胺优劣分析
Armen Mekhdjian,Morteza Sarmadi,Isabel Olson et al.
Armen Mekhdjian et al.
Nitrite scavenging is an effective strategy to control nitrosamine formation during the shelf-life of pharmaceutical drug products, particularly when other interventions are insufficient. Here, we showed that the addition of a specific nitr...
Mitigation of dose-dependent cilostazol absorption from cocrystals: A coformer regulates gastric dissolution and absorption profiles [0.03%]
共晶中剂量依赖性的西洛他唑吸收的缓解：共晶调节剂控制胃溶出和吸收行为
Takato Masada,Kohdai Yamada,Saito Akei et al.
Takato Masada et al.
The present study investigated dose-dependent effects on the oral absorption of cilostazol (CIL) from cocrystals with 4-hydroxybenzoic acid (4HBA) and attempted to mitigate these effects by adding an excess amount of intact 4HBA. With incre...
Enhancing transdermal drug delivery with dissolving microneedles: A review of optimization strategies and challenges [0.03%]
用于经皮药物输送的溶解型微针优化策略及挑战综述
Zixuan Zhang,Yongbing Sun,Haocheng Li et al.
Zixuan Zhang et al.
Microneedles represent a novel transdermal drug delivery technology that relies on micron-sized needle structures. This approach effectively penetrates the stratum corneum to achieve localized or systemic therapeutic effects, addressing the...
Pioneering the future: Delivering the first digitally generated CMC post-approval change (PAC) dossier to global regulators simultaneously [0.03%]
开创未来：向全球监管机构同时提交首个数字化生成的药品上市后变更(CMC PAC)资料包
Marquerita Algorri,Nina S Cauchon,Kabir Ahluwalia et al.
Marquerita Algorri et al.
As medicinal products and their manufacturing processes evolve, biopharmaceutical companies must continuously manage, document, and submit post-approval chemistry, manufacturing, and controls (CMC) changes to global health authorities. Trad...