Impact of injection time and protein modality on particle formation when using closed system transfer devices [0.03%]
注射时间和使用封闭系统传输设备时的蛋白质给药方式对颗粒形成的影响
John F Seeler,Bruce D Mason,Vish Swami et al.
John F Seeler et al.
The impact of injection time, protein modality and concentration/viscosity during the administration of biologics using closed system transfer devices (CSTDs) on drug product quality was investigated. Three brands of CSTDs with different si...
Cold atmospheric plasma pretreatment combined with optimized liposomal formulation for enhanced transdermal delivery of lidocaine [0.03%]
用于利多卡因透皮递送的冷等离子体预处理结合优化脂质体制剂的研究
Lord Sam B Liston,Nichakorn Nuanjan,Somchai Sawatdee et al.
Lord Sam B Liston et al.
Topical anesthetics suffer from low efficacy due to poor skin permeability. This study aims to investigate the potential of cold atmospheric plasma (CAP) pretreatment to improve skin permeation of lidocaine HCl, a local anesthetic, from an ...
Dose accuracy, parenteral material administration compatibility, surfactant choices, and formulation development in large molecules using quartz crystal microbalance [0.03%]
quartz晶体微天平在大分子药物中的剂量准确性、输液相容性、表面活性剂选择和制剂开发中的应用
Joe Weidman,Ligi Mathews,Kedar Gokhale
Joe Weidman
Making positive-impact formulation decisions for antibodies and integrated design of clinical durability creates a better drug product (DP). The goal of this study was to prevent dose loss to surfaces during clinical administration, especia...
Development of in vitro/in vivo correlation for long-acting injectable suspensions via bootstrapping [0.03%]
基于自助法的长效注射混悬液体内体外相关性研究开发
Bo Wan,Shalini Raj Unnikandam Veettil,Yi Li et al.
Bo Wan et al.
In vitro/in vivo correlation (IVIVC) is of great importance to expedite the development life-cycles for pharmaceutical industry and possibly to reduce the burden for regulatory assessment, especially for long-acting injectable (LAI) drug pr...
Ketorolac tromethamine-loaded hydrogel-forming microneedles for pediatric pain relief [0.03%]
用于儿科止痛的酮咯酸氨丁三醇载药水凝胶微针贴片
Guiyu Huang,Shuhui Chen,Yizhi Zhang et al.
Guiyu Huang et al.
Pain is particularly intolerable for children, and the analgesic regimen must be carefully managed, as systemic delivery may lead to serious side effects to growth and development of children. Therefore, the research and development of pain...
Hydroxypropyl-β-cyclodextrin/hyaluronic acid modified polydopamine nanoparticles co-loaded with BNN6 and epirubicin for synergistic photothermal/gas/chemotherapy of breast cancer [0.03%]
羟基丙基-β-环糊精/透明质酸修饰的聚多巴胺纳米颗粒共载BNN6和表阿霉素协同治疗乳腺癌的光热/气体/化疗研究
Dexue Liu,Sajid Asghar,Dan Gao et al.
Dexue Liu et al.
Combination therapy, which integrates diverse treatment modalities to induce synergistic anti-tumor effects, has emerged as a promising strategy in oncology. In this study, we developed a near-infrared (NIR) laser-triggered nitric oxide (NO...
Transient pH film model for in vitro powder dissolution of weakly basic drugs into buffer and comparison to conventional film model [0.03%]
缓冲液中弱碱性药物体外粉体溶出的pH瞬变薄膜模型及其与传统薄膜扩散模型的对比研究
Roshni P Patel,James E Polli
Roshni P Patel
The dissolution of ionizable drugs is critically influenced by the pH of the microenvironment at the solid-liquid interface, which in part can be impacted by the dissolving drug itself. For weak bases, dissolution may increase surface pH, t...
Aggregation of monoclonal and bispecific antibodies during pneumatic tube transport of IV bags in a hospital: Mitigation by polysorbate 80, poloxamer 188, and headspace removal [0.03%]
医院液袋中单克隆和双特异性抗体在气动管传输中的聚集：通过聚山梨酯80、泊洛沙姆188和去除顶空来缓解
Parham Parnian,Annette M Medina,Nidia Gonzalez Lopez et al.
Parham Parnian et al.
Pneumatic tube systems (PTS) are being increasingly used in hospitals to rapidly transport critical packages, but their mechanical stresses raise concerns for the safe transport of protein therapeutics. This study examined the impact of the...
Preparation and evaluation of 3D-printed tacrolimus tablets based on mesoporous silica solubilization [0.03%]
基于介孔二氧化硅增溶的环孢素A3D打印固体制剂的研究
Yixin Zhang,Xiaolu Han,Zhiqiang Tang et al.
Yixin Zhang et al.
Tacrolimus (FK506) has limited clinical applications due to its poor solubility and narrow therapeutic window. Therefore, strategies to enhance its solubility and enable personalized dosing are highly valuable. Recently, loading drug molecu...
Patrick J McNamara,Joseph Fleishaker,Darius Meiman
Patrick J McNamara
Purpose: To employ a comprehensive Top-Down scaling approach to estimate the impact of alterations in bioavailability (gut wall (FG) and hepatic first pass (FH,)) and clearance pathways (renal (ClR) and hepatic (ClH)) on ...