Investigation of the effects of organic acids on pH-independent drug release from extended-release hydrophilic matrix tablets: A case study with tofacitinib [0.03%]
有机酸对缓释亲水基质片pH非依赖性药物释放的影响研究：托法替尼的个例研究
Caiwei Liu,Yang Li,Qiuyue Peng et al.
Caiwei Liu et al.
Organic acids are often used as pH modifiers in extended-release (ER) formulations to achieve pH-independent release of weakly basic drugs. These acids are intended to enhance drug release at intestinal pH by modifying the microenvironmenta...
Theranostic 99mTc-labeled vancomycin-functionalized cerium oxide nanoparticles: Antibacterial efficacy, in vitro cytotoxicity, and in vivo biodistribution studies [0.03%]
用于细菌感染的诊疗一体化研究：包载万古霉素的纳米铈氧化物的抗菌性能，体外细胞毒性和体内分布研究
Mahmoud M Abouhashim,Ahmed B Ibrahim,Mohamed M Swidan et al.
Mahmoud M Abouhashim et al.
The rising prevalence of bacterial infections, and the limitations of conventional antibiotics, necessitates the development of advanced therapeutic strategies. While vancomycin is highly effective against gram-positive pathogens, its highl...
Biopolymeric Nanocapsules Exploiting the Synergistic Effects of Methotrexate and Curcumin Co-Delivery via Oral or Local Administration for Breast Cancer Therapy [0.03%]
一种口服或局部递送载体：利用甲氨蝶呤和姜黄素协同作用的纳米囊泡用于乳腺癌治疗
Ngoc Tram Nguyen Thi,Huy Q Ly,Thong Hoang Tran et al.
Ngoc Tram Nguyen Thi et al.
Alginate (ALG)-based nanocapsules for the co-delivery of methotrexate (MTX) and curcumin (CUR) have been insufficiently explored, particularly in terms of their potential use for various administration routes. This study prepared and evalua...
Corrigendum to Fabrication and Characterization of Surface Engineered Rifampicin Loaded Lipid Nanoparticulate Systems for the Potential Treatment of Tuberculosis: An In Vitro and In Vivo Evaluation Journal of Pharmaceutical Sciences Volume 110, Issue 5, p2221-2232, May 2021 [0.03%]
利福平载药脂质纳米颗粒系统的制备及表征：体内外评价——对“用于潜在治疗结核病的表面工程化利福平等药物脂质纳米颗粒系统”一文的勘误公告
Nimitt V Chokshi,Shruti Rawal,Dhruvi Solanki et al.
Nimitt V Chokshi et al.
Published Erratum
Journal of pharmaceutical sciences. 2026 Apr 16:104287. DOI:10.1016/j.xphs.2026.104287 2026
Fe²⁺-activated reactive oxygen species amplification via metal-organic frameworks loaded with paclitaxel for enhanced radiosensitivity in breast cancer radiotherapy [0.03%]
二价铁激活的负载紫杉醇金属有机框架介导的活性氧放大增敏乳腺癌放射治疗
Zohreh Daliri Sosefi,Marjan Ghorbani,Motahareh Khoshkar Foshtomi et al.
Zohreh Daliri Sosefi et al.
Cancer stands as a significant contributor to global mortality. Innovative and targeted strategies, particularly the design of purposeful nanostructures with multifunctional applications, have gained interest in chemo-radiotherapy. This app...
Beatriz Corpa-Alcalde,Carlos Ezquer-Garin,Rafael Ferriols-Lisart et al.
Beatriz Corpa-Alcalde et al.
This study evaluated the stability of insulin eye drops in three vehicles under two storage conditions. Insulin ophthalmic solution at 1 and 5 IU/ml were prepared by dilution of subcutaneous human insulin in normal saline (NS), artificial t...
SMARCA2 PROTAC-dendrimer conjugates for the treatment of non-small cell lung cancer [0.03%]
用于非小细胞肺癌治疗的SMARCA2 PROTAC-星形聚合物缀合物
Matthew O&#x;Brien Laramy,Rosliana Halim,Summer Baker Dockrey et al.
Matthew O&#x;Brien Laramy et al.
Targeted protein degradation of SMARCA2 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2) with proteolysis targeting chimeras (PROTACs) represents a promising approach for the treatment of n...
Identifying and mitigating risks during biologic drug product manufacturing: A case study using computational fluid dynamics [0.03%]
基于计算流体动力学的生物药物生产过程中的风险识别与控制案例研究
Sheetal Pai-Wechsung,James Morgan Harris,Fawziya Ali et al.
Sheetal Pai-Wechsung et al.
This case study highlights the use of computational fluid dynamics (CFD) modeling to identify and mitigate the risk of increased high molecular weight species (HMWS) formation during biologic drug product (DP) manufacturing of a multi-dose ...
Hyaluronic acid conjugated gold nanoparticles/chitosan/4-aminopyridine intranasal nanocomposites for myelin repair in multiple sclerosis [0.03%]
用于多发性硬化症髓鞘修复的透明质酸修饰金纳米粒/壳聚糖/4-氨基吡啶鼻用纳复合米材料
Jino Affrald R,Shoba Narayan
Jino Affrald R
Exploiting the therapeutic advantages of 4-Aminopyridine (4AP) in neurological conditions like multiple sclerosis (MS) are limited due to toxicity concerns and blood-brain barrier when administered through intraperitoneal or oral routes. Al...
Stability of frozen protein drug substances across concentration ranges: Case studies on the impact of formulation and freezing processes [0.03%]
冻干蛋白药物活性成分在不同浓度下的稳定性：配方和冷冻工艺影响的研究案例分析
Li Li,Serguei Tchessalov,Ruolin Lu et al.
Li Li et al.
Protein drug substances are routinely stored in frozen form to enable flexible manufacturing and transportation. Although -20°C is commonly used due to operational accessibility and cost-effectiveness, formulations stored at this temperatu...