Overcoming translational barriers in nose-to-brain drug delivery for clinical applications [0.03%]
克服鼻部给药递送药物至大脑以用于临床应用的转化障碍
Xinyue Zhang,Stephanie Chow,Ho Wan Chan et al.
Xinyue Zhang et al.
Recent research has shown an increasing interest in nose-to-brain drug delivery due to its non-invasive nature and ability to transport therapeutics directly to the central nervous system. This approach offers significant advantages over tr...
Explaining the Underlying Causes of Different Tabletability Classifications of Binary Mixtures [0.03%]
解释二元混合物不同压片性分类的内在原因
Pradeep Valekar,Ira S Buckner
Pradeep Valekar
A tabletability classification system has been previously proposed to categorize the range of tabletability behaviors of binary mixtures. 1,2 Although the proposed system has been applied in several subsequent studies, the causes of each be...
A multicompartment stomach physiologically-based pharmacokinetic model capturing gastric reacidification can improve food effect predictions of weak bases [0.03%]
一个生理药代动力学模型可以捕获胃的再次酸化，从而改善弱碱性药物的食物效应预测问题
Lisa Cheng,Po-Chang Chiang,Matthew R Wright et al.
Lisa Cheng et al.
Various changes within the gastrointestinal tract following meal intake may significantly impact oral drug absorption. Physiologically-based pharmacokinetic (PBPK) models are often used to perform early predictions of food effects on oral a...
Application of ion-exchange chromatographic technique using resins to prepare the salts of polar unstable prodrugs and new chemical entities (NCEs) [0.03%]
离子交换色谱技术在制备极性不稳定的前药和新化学实体(NCEs)的盐中的应用
Raja K Rit,V Venkataramasubramanian,V Deepika et al.
Raja K Rit et al.
Prodrugs are inactive and bio-reversible derivatives of drugs or clinical candidates. Prodrugs and New Chemical Entities (NCEs) often do not show good bioavailability primarily due to poor solubility. One of the strategies to overcome this ...
Zahraa Al-Tamimi,Mei Feng,Waleed Elballa et al.
Zahraa Al-Tamimi et al.
Despite significant advancements in peptide drug development, there is still a challenge in formulating and delivering peptide drugs orally. Current oral peptide drugs have very low bioavailability (
Experimental determination of extinction coefficients by sedimentation velocity analytical ultracentrifugation for accurate quantification of recombinant adeno-associated virus [0.03%]
利用分析超速离心法测定沉淀速度实验以确定消光系数从而准确量化重组腺相关病毒数量
Yuki Yamaguchi,Takahiro Maruno,Takaaki Kurinomaru et al.
Yuki Yamaguchi et al.
Recombinant adeno-associated virus (rAAV) is widely used as a gene delivery vector. Sedimentation velocity analytical ultracentrifugation (SV-AUC) is the gold standard for quantifying the ratio of full particles (FPs) to the sum of empty pa...
Interaction of isoniazid derivatives active against drug-resistant tuberculosis with models of the lung surfactant and of the Mycobacterium tuberculosis cell wall [0.03%]
异烟肼衍生物与肺表面活性剂和结核分枝杆菌细胞壁模型的相互作用
Weronika Śliżewska,Filomena Martins,Rodrigo F M de Almeida et al.
Weronika Śliżewska et al.
Tuberculosis is one of the most important causes of death in the world. The emergence and increased prominence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), non-susceptible to currently available therapies, has toughen...
Preparation and characterization of oral insulin-trimethyl chitosan complex-loaded solid self-nanoemulsifying drug delivery systems (SNEDDS) [0.03%]
口服胰岛素-三甲基壳聚糖复合载药固态自微乳化药物递送系统(SNEDDS)的制备及表征
Richieline S Cual,Tajmarah Ayyah M Sandato,Mae Quenie T Pontanar
Richieline S Cual
Insulin, a pancreatic hormone regulating blood glucose, is available in forms of syringe, pen, or implants; however, these methods presented challenges related to skin adverse reactions and patient compliance. Oral insulin delivery has long...
Photodegradation of dacarbazine irradiated by common lighting sources: An examination of the differences between light-emitting diode (LED) and fluorescent light [0.03%]
达卡巴嗪经常见光源光解降解的差异性能研究：关于发光二极管(LED)与荧光灯的对比研究
Shun Takayama,Yukiko Nagai,Tomomi Sugiyama et al.
Shun Takayama et al.
Light-sensitive pharmaceuticals are susceptible to alteration or degradation under ambient light conditions, such as sunlight or artificial lighting, requiring pharmacists and patients to prevent exposure of these drugs to light. However, t...
Design and synthesis of carbamate-linked ester prodrugs selectively activated by carboxylesterase 1 with enhanced stability against intestinal hydrolysis [0.03%]
一种增强型肠道稳定性且能被羧酸酯酶1选择性激活的氨基甲酸酯连接酯前药的设计与合成
Masato Takahashi,Shintaro Sakamoto,Nao Sakamoto et al.
Masato Takahashi et al.
Ester-based prodrugs are often prematurely hydrolyzed by intestinal carboxylesterases, leading to reduced bioavailability and potential gastrointestinal (GI) toxicity. To overcome this limitation, a series of diester, carbonate-linked ester...