Development of an active loading strategy for methylene blue in liposomes and its application in EGFR-targeted photodynamic therapy [0.03%]
用于脂质体的亚甲蓝主动加载策略的发展及其在EGFR靶向光动力治疗中的应用
Guozi Xia,Rui Cao,Lizhen Huang et al.
Guozi Xia et al.
As an ancient drug, methylene blue (MB) has shown promise in tumor photodynamic therapy (PDT) due to its excellent light-induced reactive oxygen species (ROS) yield. However, its rapid plasma clearance and lack of tumor targeting have limit...
Navigating the complexities in characterization of NDSRIs using advanced analytical techniques [0.03%]
利用先进分析技术剖析NDSRI的复杂性
Koushik Mondal,Veera Reddy,Suresh Kumar Sk et al.
Koushik Mondal et al.
The accurate detection and quantification of nitrosamine drug substance related impurities (NDSRIs) requires validated analytical techniques. However, the availability of standards for validation is still evolving due to the structural comp...
Determination of naloxone and its impurities in a vaporized matrix by LC-MS/MS: Application of an in vitro surrogate model platform to assess in vivo permeation and risk associated with vaping opioids [0.03%]
液相色谱-质谱联用测定纳络酮及其杂质：体外替代模型平台评估吸入式阿片类药物渗透及风险的应用
Dustin G Brown,Tasmin Ara Sultana,Patrick Faustino et al.
Dustin G Brown et al.
E-cigarette use in the U.S. has risen over the past decade, particularly among youth and young adults, prompting potential public health concerns. In response, public health agencies including the FDA have initiated studies to assess associ...
Preparation of novel in situ film-forming gel impregnated with clotrimazole-loaded liquid crystalline nanoparticles: In vitro, ex vivo, in vivo dermatopharmacokinetic and antifungal evaluation [0.03%]
载有克霉唑负载型液晶纳米粒的新型就位成膜凝胶的制备及体外、离体及抗真菌评价
Radhika Sharma,Gautam Singhvi,Vikas Rana
Radhika Sharma
In an attempt to conquer the significant concerns, viz. patient discomfort due to repeated application, low skin permeability, retention, and low therapeutic efficacy of conventional topical formulations (creams, ointments, etc.) for the ma...
Corrigendum to Mechanistic Insights into Drug Loading Effect on Dissolution Performance of Loratadine-Soluplus® Amorphous Solid Dispersions [0.03%]
洛拉替丁-索鲁普鲁斯均质固态分散体的药物载药量效应对溶解性能影响的机制研究校正意见
Jannat Falah Hassan,Kawther Khalid Ahmed,Tze Ning Hiew
Jannat Falah Hassan
Published Erratum
Journal of pharmaceutical sciences. 2026 Feb 16:104211. DOI:10.1016/j.xphs.2026.104211 2026
Successful bioequivalence prediction of immediate-release vortioxetine tablets through prospective virtual crossover and parallel trials [0.03%]
通过前瞻性虚拟交叉和并行试验成功预测文拉法辛即释片的生物等效性
Dorota Danielak,Marcela Staniszewska,Svitlana Romanova et al.
Dorota Danielak et al.
We prospectively conducted virtual bioequivalence (VBE) trials under fasted conditions to guide a clinical trial design and candidate selection for a model drug with a long elimination half-life. We combined biopredictive dissolution method...
Targeted transdermal scopolamine delivery over the salivary glands for sialorrhea: Dose-response and systemic safety in rats [0.03%]
针对唾液腺的东莨菪碱透皮给药治疗流涎症：剂量反应及系统安全性研究（大鼠模型）
Natsuko Ishida,Koichi Takagaki,Mutsumi Urayama et al.
Natsuko Ishida et al.
Sialorrhea is a common and distressing symptom in patients with neurological disorders, often impairing quality of life and increasing the risk of aspiration. Although oral anticholinergic agents are widely prescribed, their systemic side e...
Sodium-activated Algerian bentonite with improved surface properties and topical barrier performance [0.03%]
具有改善的表面性能和皮肤屏障效果的钠激活的阿尔及利亚蒙脱石
Rania Chebani,Khedidja Tahar Djebbar,Kamel Daoud
Rania Chebani
This study investigates whether sodium activation can turn an under-utilized Algerian calcium bentonite into a topical barrier-oriented clay with measurable barrier-relevant performance in a model of inflammatory skin barrier dysfunction. R...
Developability assessments with four mRNA-LNP vaccine formulations comparing mouse immunogenicity, structural attributes, and stability profiles [0.03%]
四种mRNA-LNP疫苗配方的可开发性评估：比较小鼠免疫原性、结构特征和稳定性表征
Max Fairlamb,Ozan S Kumru,John M Hickey et al.
Max Fairlamb et al.
A standardized developability workflow to rank-order the stability profiles of mRNA-LNP vaccine formulations is described. As proof-of-concept, three experimental mRNA-LNP formulations with varying lipid compositions were benchmarked agains...
Long-acting injectable microsphere of crosslinked collagen encapsulates solid dispersion to enhance bioavailability of aripiprazole [0.03%]
交联胶原微球包封的艾司西酞普兰固态分散体系长效注射剂以提高生物利用度
Shanglun Li,Xiaoxuan Ji,Wei Huang et al.
Shanglun Li et al.
Aripiprazole (APZ) injectable formulations have been developed to address the poor patient compliance associated with its oral dosage forms for the long-term treatment of schizophrenia. However, the solubility of APZ decreases as the pH inc...