Understanding real-time water penetration dynamics in tablets using synchrotron X-ray micro-computed tomography [0.03%]
应用同步加速器X射线微计算机断层扫描理解片剂中水的实时渗透动力学现象
Denis Kalugin,Prajwal Thool,Carter Blocka et al.
Denis Kalugin et al.
Understanding the initial water penetration dynamics in pharmaceutical tablets is critical - a precursor to drug bioavailability, yet the underlying mechanisms remain poorly understood. Using in-situ synchrotron X-ray-based micro-computed t...
Flow imaging for particle characterization and quantification in biologicals: A perspective from the Japanese Biopharmaceutical Consortium [0.03%]
日本生物制药协会谈流动成像技术在生物药微粒表征和定量中的应用
Hiroko Shibata,Tim Menzen,Andrea Hawe et al.
Hiroko Shibata et al.
Protein aggregates and particles in biologicals are considered impurities and critical quality attributes because they could elicit immunogenicity. An appropriate control strategy should be established to monitor and control them following ...
Letter to the editor on "Analysis of the formation of (sub)visual particles in ready-to-administer trastuzumab infusion bags during transport" [0.03%]
关于“曲妥珠单抗成品输液袋在运输过程中(sub)可见微粒形成分析”的来信回复
Muhammad Asad Abbas,Muhammad Sheharyar Bhojani,Muhammad Hussain
Muhammad Asad Abbas
Evaluation of dimethyl sulfoxide-free formulations for cryopreservation of human T cells [0.03%]
无二甲基亚砜配方在人T细胞冷冻保存中的评价研究
Alexandra Roesch,Roland Windisch,Christian Wichmann et al.
Alexandra Roesch et al.
Chimeric antigen receptor (CAR) T cells are stored cryopreserved at temperatures below -145°C. Cryopreservation formulations typically contain dimethyl sulfoxide (DMSO) at concentrations between 5% and 10% DMSO, which effectively protects ...
Formulation and evaluation of a dual-drug film-forming topical gel for synergistic antifungal therapy against cutaneous candidiasis [0.03%]
一种针对皮肤念珠菌病的协同抗真菌疗法的双药成膜型凝胶制剂及其评价研究
Hiral Girase,Mahavir Narwade,Abdulrhman Alsayari et al.
Hiral Girase et al.
Cutaneous candidiasis remains a therapeutic challenge owing to limited skin penetration of anti-fungal agents, high recurrence, and increasing resistance to azoles. In this work, a chitosan-based film-forming gel (FFG) was developed incorpo...
Cocrystals of telmisartan with ascorbic acid: Enhanced solubility and antiviral potency against Japanese encephalitis virus [0.03%]
依托考昔与抗坏血酸共晶：对日本脑炎病毒的增强溶解度和抗病毒功效
Varaprasad Rao Regu,Ankita Datey,Tompe Krishna Vitthal et al.
Varaprasad Rao Regu et al.
The significant impact of Japanese encephalitis virus (JEV) on society and the lack of any approved antiviral drugs demand urgent attention. Considering the prohibitive cost involved in new antiviral development, repurposing existing drugs ...
Silicone-oil migration in prefilled syringes induces smoke-like particulates in ultra-high viscosity formulations [0.03%]
预填充注射器中硅油的迁移会导致超高粘度配方产生烟雾状颗粒物
Yunjiao Chi,Xingchun Jiang,Jun Li et al.
Yunjiao Chi et al.
Visible smoke-like particles are occasionally observed in ultra-high viscosity (UHV) formulations, such as ophthalmic viscosurgical devices (OVDs), stored in prefilled syringes (PFS), leading to reduced product yield. In this study, spatial...
Mechanistic dermal patch modelling for fentanyl: Linking in vitro release and permeation data to a physiologically based pharmacokinetic approach [0.03%]
基于生理的药代动力学方法联系体外释放和渗透数据进行芬太尼透皮贴剂建模研究
Daniel Paterson,Yanling Zhang,Sebastian Polak et al.
Daniel Paterson et al.
Dermal physiologically based pharmacokinetic (PBPK) models can be informed by various types of data. In vitro permeation testing (IVPT) experiments aid parameterisation of skin permeation independent of the complexities of systemic uptake. ...
Rule-based mitigation of charge asymmetry-triggered monoclonal antibody self-assembly [0.03%]
基于规则的缓解电荷不对称引起的单克隆抗体自组装
Inna Brakti,Anette Henriksen,Maria Łucja Tomczak et al.
Inna Brakti et al.
When evaluating the proclivity of a monoclonal antibody (mAb) for non-specific self-assembly, it is common to restrict charge distribution analyses to the variable region of mAbs, leaving out possible contributions from the constant region ...
Corrigendum Engineering of Layer-By-Layer Acetate Coated Paclitaxel Loaded Poly(lactide-Co-Glycolide Acid Nanoparticles for Prostate Cancer Therapy- In Vitro Journal of Pharmaceutical Sciences Volume 113, Issue 11, November 2024, Pages 3375-3383 [0.03%]
用于前列腺癌治疗的分层醋酸涂层载 paclitaxel 聚(l-乳酸-co-glycolide)纳米颗粒的工程化-体外研究（《药物科学杂志》第113卷，第11期，2024年11月，页码3375-3383 的更正）
Albert Nguessan Ngo,Kierston K Chatman,Dezirae Douglas et al.
Albert Nguessan Ngo et al.
Published Erratum
Journal of pharmaceutical sciences. 2026 Feb 19:104216. DOI:10.1016/j.xphs.2026.104216 2026