Enhanced zika virus suppression by coupling ribavirin with biodegradable drug delivery [0.03%]
利用可生物降解的药物输送结合核糖霉素增强对寨胺病毒的抑制作用
Julissa Rodriguez,Asa Waterman th,Maria R Blahove et al.
Julissa Rodriguez et al.
Advancement and implementation of nanoparticle-based systems for enhanced drug delivery have become essential for the suppression of viral pathogens due to lack of viable treatment options. This study focuses on characterization and applica...
Vincent Chak,Sathy Balu-Iyer
Vincent Chak
Unwanted immune responses lead to several clinical conditions, including autoimmune diseases, allergies, and anti-drug antibody formation against biological therapeutic modalities. To address these challenges, tolerance-inducing strategies ...
Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences [0.03%]
绿色的、可再生的还是低碳的？药学科学中溶剂选择的框架
Md Sajjadur Rahman,William Hiers,Andrew Davidson et al.
Md Sajjadur Rahman et al.
Pharmaceutical companies have largely committed to achieving net-zero goals with both short-term and long-term science-based targets. At the same time, drug quality, safety and regulatory compliance must continue to be met. While solvent su...
Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI [0.03%]
一种用于磁共振成像导向的索拉非尼靶向递送的瑞莫单抗多功能磁脂质体的诊疗潜力研究
Ali Pouresmaeili,Abolghasem Abbasi Kajani
Ali Pouresmaeili
Development of theranostic nanoplatforms capable of the controlled and targeted delivery of anticancer agents and simultaneous bioimaging has attracted great attention as an exciting and frontier research field. Here, the sorafenib loaded m...
Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation [0.03%]
雷南平通过鼻腔给药的壳聚糖微球制剂、设计和药代动力学评价
Gyati Shilakari Asthana,V Shilpa,B Geethika Reddy et al.
Gyati Shilakari Asthana et al.
Ranolazine is an established antianginal agent; however, its oral administration is associated with delayed onset of action and variable systemic exposure due to extensive hepatic first-pass metabolism. Intranasal drug delivery is a non-inv...
Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs [0.03%]
儿科罕见病药物开发的演变——从成功到解决未满足需求的策略
Sydney Stern,Yifei Zhang,Michelle Pressly et al.
Sydney Stern et al.
Over 7,000 rare diseases have been identified and 50-75% of them impact pediatrics. Pediatric rare diseases represent a critical unmet need, as nearly 95% of these conditions lack FDA-approved therapies. Progress, through scientific innovat...
A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry [0.03%]
基于颗粒大小分布和模具几何形状的片重分散度预测数学模型框架
Rajarshi Sengupta,Y-H Kiang,Behzad Changalvaie et al.
Rajarshi Sengupta et al.
Tablet weight variability is a critical quality attribute in solid oral dosage manufacturing. Despite its practical importance, existing approaches for relating tablet weight variability to formulation and tooling parameters remain largely ...
Recrystallization can stop nitrosamine formation in ranitidine hydrochloride [0.03%]
重结晶可避免雷尼替丁中亚硝胺形成
Jianchao Xu,Yijing Huang,Jon Selbo et al.
Jianchao Xu et al.
Nitrosamines, first identified in the 1950s as carcinogenic contaminants in food, tobacco, and industrial chemicals. Among them, N-nitrosodimethylamine (NDMA) is particularly dangerous due to its high carcinogenicity and frequent occurrence...
Corrigendum to 'Antipsychotic Potential and Safety Profile of TPGS-Based Mucoadhesive Aripiprazole Nanoemulsion: Development and Optimization for Nose-To-Brain Delivery' [Journal of Pharmaceutical Sciences 110/4 (2021) 1761-1778] [0.03%]
“TPGS基黏附型二甲双胍纳米乳的抗精神病潜力及安全特征：鼻用给药递送的开发与优化”校正案
Santosh Ashok Kumbhar,Chandrakant R Kokare,Birendra Shrivastava et al.
Santosh Ashok Kumbhar et al.
Published Erratum
Journal of pharmaceutical sciences. 2026 Jun 18:104397. DOI:10.1016/j.xphs.2026.104397 2026
In vitro hepatocyte uptake-based estimation of tissue partition coefficients of basic compounds for PBPK modeling [0.03%]
基于体外肝细胞摄取的基本化合物组织分配系数的PBPK模型估算
Nilesh Gaud,Magdalena Miodek,Roza Starczak et al.
Nilesh Gaud et al.
Accurate prediction of tissue-to-plasma partition coefficients (Kp,tissue) is critical for physiologically based pharmacokinetic (PBPK) modeling, particularly for basic compounds (pKa > 7) that display complex distribution driven by lysosom...