Probing surfactant protein B fragments as endogenous RNA carriers for pulmonary delivery [0.03%]
探究肺部递送的内源性RNA载体——两性离子表面活性剂蛋白B片段
Michael Y T Chow,Paulina Goldbaum,Cheng Ma et al.
Michael Y T Chow et al.
Pulmonary delivery of gene therapy holds significant clinical potential. While pulmonary administration of naked RNA could induce modest transfection in lung tissues, the underlying transfection mechanisms remain unclear. A hypothesis sugge...
Pharmacokinetics and safety study of methylphenidate hydrochloride sustained-release tablets in Chinese healthy participants [0.03%]
盐酸哌甲酯缓释片在中国健康受试者中的药代动力学和安全性研究
Di Zhou,Yinxia Li,Lijuan Ning et al.
Di Zhou et al.
This study aims to investigate the pharmacokinetic (PK) properties and safety of generic versus brand-name methylphenidate hydrochloride (MPH) sustained-release tablets (Concert®) under fasting and fed conditions, and to evaluate bioequiva...
Hot melt extrusion-driven cocrystallization of aceclofenac with nicotinamide: A strategy to enhance solubility, bioavailability, and therapeutic effect [0.03%]
对乙酰氨基酚与烟酸的熔融共挤出物制备及其溶解度、生物利用度和药效的改善策略研究
Sneha Balu Govind,Elvis A F Martis,Vaishali Ashish Shirsat
Sneha Balu Govind
Aceclofenac (ACF) is a commonly used non-steroidal anti-inflammatory drugs (NSAID) for numerous inflammatory conditions; however, its therapeutic potential is limited due to suboptimal solubility. Pharmaceutical cocrystals have demonstrated...
Something in the air-Unveiling the role of atmospheric nitrogen oxides in nitrosamine formation from amine-containing APIs: Mechanistic insights and risk assessment [0.03%]
空气中有什么作用-揭示大气氮氧化物在胺类药物活性成分形成亚硝胺中的作用：机制见解和风险评估
Rok Grahek,Renat Selimov,Miha Drev et al.
Rok Grahek et al.
Atmospheric nitrogen oxides (NOx) have emerged as a potential contributor to nitrosamine formation in active pharmaceutical ingredients (APIs) containing vulnerable amines. This study investigates the extent and mechanisms of NOx-mediated n...
First step towards predicting clinical immunogenicity of biologics using in vitro based readouts as animal trial alternatives [0.03%]
利用体外读出代替动物试验预测生物制品临床免疫原性的第一步
Sudhanshu Agnihotri,Aditi Venkatesh,Murali Ramanathan et al.
Sudhanshu Agnihotri et al.
Immunogenicity risk assessment is a critical step in the therapeutic development process of biologics. However, anti-drug antibodies continue to occur in the clinic, compromising safety and efficacy and contributing to discontinuation of ot...
Eliminating liquid chromatography-induced methionine oxidation of monoclonal antibodies using high-concentration TCEP injections: The "anTCEPtic" column cleaning method [0.03%]
使用高浓度TCEP冲洗消除单克隆抗体的液相色谱诱导型甲硫氨酸氧化：“抗TCEP”柱清洗法
Andrew Kleinberg,Joy Yoon,Yuan Mao et al.
Andrew Kleinberg et al.
Artificial oxidation of methionine residues during LC/MS analysis of peptide mapping samples is a common issue arising from multiple possible contamination sources. Accurate monitoring of post-translational modifications (PTMs) is critical ...
Semi-solid extrusion 3D printing of milk formula-based paediatric chewable dosage forms [0.03%]
基于婴儿配方奶粉的半固体挤压3D打印儿科可咀嚼剂型
Konstantina Chachlioutaki,Zisis Chatzis,Nikolaos Bouropoulos et al.
Konstantina Chachlioutaki et al.
Age-appropriate oral medicines remain limited for patients with swallowing difficulties, especially children. We present a chewable, drug delivery platform that uses milk formula as the primary excipient for semi-solid extrusion (SSE) 3D pr...
Co-amorphization of felodipine with puerarin: Enhanced dissolution, photostability and oral bioavailability [0.03%]
非洛地平与黄芪甲苷共无定形化：改善溶解性、光稳定性及口服生物利用度
Yawen Tian,Jiayan Shi,Tiantian Li et al.
Yawen Tian et al.
The antihypertensive drug felodipine (FEL) suffers from poor solubility, leading to low bioavailability, and is also known to undergo photodegradation. Co-amorphous formulations represent a promising strategy for simultaneously enhancing th...
A phospholipid-like charge-reversible lipid for PEG-free, stable, and low-inflammatory mRNA lipid nanoparticles [0.03%]
一种类似磷脂的电荷可逆脂质，用于制备PEG-free且稳定、低炎性的mRNA脂质纳米颗粒
Peihan Sha,Sumika Maeshima,Hiroyuki Koide et al.
Peihan Sha et al.
The development of lipid nanoparticles (LNPs) facilitated optimal usage of mRNA drugs to achieve clinical success during the COVID-19 pandemic. Conventional LNPs rely on ionizable lipids for mRNA encapsulation and endosomal escape. However,...
Reimagining Carrier-Based Formulations for Inhalation: Respirable Agglomerates [0.03%]
用于吸入的载药制剂的再思考：呼吸性聚集体
Jeffry G Weers,Thomas E Tarara,Danforth P Miller
Jeffry G Weers
Carrier-based formulations comprising interactive mixtures of micronized drug particles and coarse lactose monohydrate carrier particles were designed to overcome the strong interparticle cohesive forces associated with fine, respirable dru...