Investigation on the antitumor and antibacterial performance of photothermally active molybdenum oxide materials [0.03%]
具有光热活性的钼氧化物材料的抗肿瘤和抗菌性能研究
Hongmei Bai,Ping Zhang,Shihai Chen et al.
Hongmei Bai et al.
Post-surgical breast cancer management remains limited by systemic toxicity, residual tumor burden, and infection risk. To address these issues, we developed an intelligent nanoplatform (MoOx@DOX@LNT) for the co-delivery of oxygen-deficient...
Quantitative prediction of human metabolites formed from the oxidation of the alcohol group of the glucokinase activator, TMG-123, using chimeric mice with humanized livers [0.03%]
TMG-123（一种糖激酶激活剂）的人体代谢物定量预测及其氧化反应研究（利用肝脏人类化嵌合小鼠）
Akiko Watanabe,Seishiro Sakamoto,Shigeru Ohta et al.
Akiko Watanabe et al.
Pharmacokinetic (PK) predictions in humans are important for both the parent compounds and their metabolites, as these predictions help decide whether to progress to human clinical trials. More human PK prediction studies have been conducte...
Sericin and alginate loaded nanocomposite hydrogels for encapsulation and oral administration of insulin [0.03%]
丝素和海藻酸盐负载纳米复合水凝胶用于胰岛素的封装及口服给药
Sania Faiz,Hafiz Muhammad Tahir,Rida Mahnoor et al.
Sania Faiz et al.
Diabetes mellitus is a major global health concern, with limited progress in the development of efficient oral insulin formulations. The current study was designed to assess the physicochemical, biochemical, and therapeutic efficiency of al...
Promising purine-silver nanoparticles for tumor theranostic: Synthesis, radiolabeling, in vitro cytotoxicity, structure-activity relationship, and in vivo biodistribution studies [0.03%]
具有治疗诊断潜力的嘌呤-银纳米颗粒：合成，放射标记，体外细胞毒性，构效关系及体内生物分布研究
Hesham A Shamsel-Din,Ahmed B Ibrahim
Hesham A Shamsel-Din
Purine derivatives are valuable anticancer agents, but their limited stability and poor tumor selectivity restrict therapeutic efficacy. This study aimed to overcome these barriers by designing a multifunctional radiotheranostic system inte...
Direct Analysis of Subvisible Particles in Pharmaceutical Drug Products with Non-invasive Mie-scattering Light Sheet Technology: Profiling Inherent Particle Growth in Monoclonal Antibody Solutions [0.03%]
采用非侵入式Mie散射薄片光技术直接分析药物产品中的亚可见颗粒：单克隆抗体溶液中固有颗粒增长表征
Benjamin Laccetti,Mingshu Liang,Monica Goss et al.
Benjamin Laccetti et al.
Enumerating and sizing subvisible particles (SbVP) is an important aspect of ensuring pharmaceutical drug product (DP) quality. Existing SbVP characterization is limited by the destructive nature of testing methods and the need to withdraw ...
Generalized flow imaging microscopy instrument settings for measuring subvisible particle sizes and concentrations in protein therapies [0.03%]
蛋白质治疗中亚可见颗粒大小和浓度测定的广义流动成像显微镜仪器设置
Austin L Daniels,Sushma Parab,Sigrid C Kuebler et al.
Austin L Daniels et al.
Flow imaging microscopy (FIM) is a common imaging-based technique for measuring the subvisible particle content of protein therapies. FIM measurement accuracy strongly depends on particle segmentation, the process of detecting particles in ...
Do we worry too much about polysorbate degradation? An industry-wide perspective with real-life case studies [0.03%]
聚山梨酯降解问题真的需要担忧吗？来自行业的广泛观点及真实案例分析
Klaus Wuchner,Felix Nikels,Patrick Garidel et al.
Klaus Wuchner et al.
Polysorbates are commonly used in biotherapeutic drug formulations, but their stability over the course of the product's shelf life is a matter of concern. An industry-wide survey involving 15 biopharmaceutical companies found that 23 bioth...
Control strategy for subvisible particulates of therapeutic protein injections in pre-filled syringes using flow imaging [0.03%]
流动成像法在预装注射器中治疗蛋白药物亚可见颗粒控制策略的研究
Bin Zhang,Katiria Flores,Nathyn Horvath et al.
Bin Zhang et al.
Pre-filled syringes (PFSs) are a widely used container closure for therapeutic protein injections, enabling simplified preparation and at-home administration. PFSs are commonly lubricated with sprayed-on silicone oil (SiO), which may migrat...
Long-acting delivery of a model monoclonal antibody from ethylene vinyl acetate implants at a high loading: Drug release and protein stability [0.03%]
乙烯基乙酸酯植入剂中高载药量模型单克隆抗体的长效递送：药物释放和蛋白稳定性研究
Yu Tong Tam,Harsh Patel,Jeffrey C Haley et al.
Yu Tong Tam et al.
Delivering large therapeutic monoclonal antibodies (mAbs) from solid polymer matrices via hot-melt extrusion (HME) is a promising approach to achieving a prolonged release profile. However, this approach presents significant challenges due ...