Prediction of vancomycin exposure in patients with central nervous system infections using physiologically based pharmacokinetic modeling [0.03%]
基于生理的药代动力学模型在中枢神经系统感染患者万古霉素暴露量预测中的应用
Ya-Xin Liu,Yun Kuang,Jin-Long Liu et al.
Ya-Xin Liu et al.
Vancomycin remains a key therapeutic option for central nervous system (CNS) infections caused by Gram-positive bacteria, yet its limited and variable penetration into the cerebrospinal fluid (CSF) poses challenges for optimal dosing. This ...
Advantages and limitations of the inclusion of ascorbic acid on nitrosamine mitigation in pharmaceutical drug products [0.03%]
维生素C在药物产品中抑制亚硝胺优劣分析
Armen Mekhdjian,Morteza Sarmadi,Isabel Olson et al.
Armen Mekhdjian et al.
Nitrite scavenging is an effective strategy to control nitrosamine formation during the shelf-life of pharmaceutical drug products, particularly when other interventions are insufficient. Here, we showed that the addition of a specific nitr...
Mitigation of dose-dependent cilostazol absorption from cocrystals: A coformer regulates gastric dissolution and absorption profiles [0.03%]
共晶中剂量依赖性的西洛他唑吸收的缓解：共晶调节剂控制胃溶出和吸收行为
Takato Masada,Kohdai Yamada,Saito Akei et al.
Takato Masada et al.
The present study investigated dose-dependent effects on the oral absorption of cilostazol (CIL) from cocrystals with 4-hydroxybenzoic acid (4HBA) and attempted to mitigate these effects by adding an excess amount of intact 4HBA. With incre...
Enhancing transdermal drug delivery with dissolving microneedles: A review of optimization strategies and challenges [0.03%]
用于经皮药物输送的溶解型微针优化策略及挑战综述
Zixuan Zhang,Yongbing Sun,Haocheng Li et al.
Zixuan Zhang et al.
Microneedles represent a novel transdermal drug delivery technology that relies on micron-sized needle structures. This approach effectively penetrates the stratum corneum to achieve localized or systemic therapeutic effects, addressing the...
Pioneering the future: Delivering the first digitally generated CMC post-approval change (PAC) dossier to global regulators simultaneously [0.03%]
开创未来：向全球监管机构同时提交首个数字化生成的药品上市后变更(CMC PAC)资料包
Marquerita Algorri,Nina S Cauchon,Kabir Ahluwalia et al.
Marquerita Algorri et al.
As medicinal products and their manufacturing processes evolve, biopharmaceutical companies must continuously manage, document, and submit post-approval chemistry, manufacturing, and controls (CMC) changes to global health authorities. Trad...
Development of a mechanistic in vitro-in vivo correlation for upadacitinib using physiologically-based pharmacokinetic modeling [0.03%]
基于生理的药代动力学模型的乌帕替尼机理体内体外关联的发展研究
Md Mahbubul Huq Riad,Sumit Bhatnagar,Susan George et al.
Md Mahbubul Huq Riad et al.
A physiologically-based pharmacokinetic (PBPK) model was successfully developed to describe the absorption, distribution, metabolism, and excretion processes for the upadacitinib 15 mg, 30 mg, and 45 mg extended-release (ER) formulations. A...
Enhanced antifungal therapy for cutaneous candidiasis: Development, evaluation, and optimization of luliconazole-loaded transethosomal gel [0.03%]
用于皮肤念珠菌病的改良抗真菌疗法： luliconazole载药转移脂质体凝胶的研发、评估及优化
Mohamed A Akl,Mahmoud M El-Sonbaty,Tarek M Ibrahim et al.
Mohamed A Akl et al.
Cutaneous Candidiasis, a widespread opportunistic fungal infection primarily caused by Candida albicans, accounts for 1% of outpatient and 7% of inpatient dermatology consultations. The rise in antifungal resistance due to genetic mutations...
Changing the container closure system of lyophilized products: Real or perceived risk to process efficiency and product quality? [0.03%]
影响冻干产品的容器密封系统变更：对工艺效率和产品质量的真正风险还是感知到的风险？
Maxwell Korang-Yeboah,Ann-Marie Afrifa,Lisa Ma et al.
Maxwell Korang-Yeboah et al.
The container-closure system (CCS), specifically the glass vial, plays a pivotal role in heat transfer during lyophilization, thereby influencing process efficiency and product quality. Therefore, a change in CCS without corresponding chang...
Mechanistic insights into drug loading effect on dissolution performance of Loratadine-Soluplus® amorphous solid dispersions [0.03%]
洛拉替丁-索鲁普卢斯无定型固体分散体中载药量对药物溶出性能影响的机制研究
Jannat Falah Hassan,Kawther Khalid Ahmed,Tze Ning Hiew
Jannat Falah Hassan
Amorphous solid dispersions (ASDs) hold promising potential towards modulating the solubility of poorly soluble drugs. However, their use is limited by poor understanding of release mechanism and kinetics, especially with Soluplus®. In thi...
Reply to Maboudi's Comment on "Formulation and In Vitro Evaluation of Liposomal and SMEDDS-Based Cannabidiol Delivery Systems" [0.03%]
对Maboudi关于“大麻二酚脂质体和SMEDDS递送系统的设计与体外评价”的评论的回复
Chrystalla Protopapa,Ioannis Tsichlis,Siva Satyanarayana Kolipaka et al.
Chrystalla Protopapa et al.