Pediatric extended-release oral formulations: A U.S. market landscape analysis [0.03%]
美国儿童缓控释口服制剂市场分析报告
Hwee Jing Ong,Y-H Kiang,Bhanu Bejgum et al.
Hwee Jing Ong et al.
Extended-release (ER) oral formulations provide therapeutic and practical benefits for pediatric patients by minimizing fluctuations in systemic exposure, reducing dosing frequency, and improving adherence. However, few reviews of ER formul...
Supercooled liquid state facilitates recrystallization-mediated gelation of amorphous cinnarizine [0.03%]
过冷液相介导无定形西尼地平的重结晶凝胶化过程
Yutong Li,Manlin Teng,Sining Han et al.
Yutong Li et al.
Amorphization is an effective strategy for enhancing the solubility of poorly water-soluble drugs. However, its benefits can be compromised by gelation-a counterintuitive phenomenon that leads to decreased dissolution behavior compared to t...
Self-assembled polymeric prodrug provides controlled cisplatin release and enhanced efficiency in local chemotherapy [0.03%]
自组装聚合物前药控制顺铂释放并提高局部化疗效率
Mohamed M Abdelghafour,Bence Kutus,László Mérai et al.
Mohamed M Abdelghafour et al.
In this work, we report the synthesis of novel polymeric prodrug nanoparticles of cisplatin to reduce the severe side effects of cisplatin and investigate its potential localized delivery to aerodigestive tract carcinomas. Cisplatin was con...
Predicting surfactant effects on drug permeation across hollow fiber membrane [0.03%]
预测表面活性剂对药物穿过中空纤维膜渗透的影响
Roshni P Patel,Jack D Murray,Brendan T Griffin et al.
Roshni P Patel et al.
The hollow fiber membrane (HFM) system is a potential combined dissolution/permeation in vitro tool to predict oral solid dosage form performance. However, drug permeability interpretation in the presence of surfactants remains mechanistica...
Dissolved oxygen effects on human growth hormone stability during freeze-thaw and metal-catalyzed oxidation [0.03%]
溶解氧对人成长激素在冻融和金属催化氧化中的稳定影响
Yuya Miyahara,Ricarda Nagel,Wolfgang Friess
Yuya Miyahara
Dissolved oxygen (DO) has been proposed to influence protein stability during freeze-thaw (F/T) processing, yet its direct impact remains unclear. This study evaluated whether DO levels or vacuum degassing affect the stability of human grow...
Nano-enabled targeted transdermal therapy for pain management in cervical cancer [0.03%]
用于宫颈癌镇痛的纳米载体经皮给药治疗
Beatrice Odei-Mensah,Samson A Adeyemi,Lindokuhle M Ngema et al.
Beatrice Odei-Mensah et al.
Cervical cancer, caused by persistent infection with high-risk human papillomavirus (HPV) types, remains one of the leading causes of cancer death among women. Pain is a significant concern in patients with advanced disease, due to the anat...
Impact of pneumatic tube system transportation on product quality of therapeutic monoclonal antibody liquid drug products filled in vials and pre-filled syringes [0.03%]
气动传输系统对瓶装和预充式注射器中治疗性单克隆抗体液体药物产品质量的影响
Kashappa Goud Desai,Cait Sofa,James D Colandene et al.
Kashappa Goud Desai et al.
Pneumatic tube systems (PTSs) offer rapid intra-hospital transport but may affect the quality of therapeutic monoclonal antibody (mAb) liquid drug products. This study demonstrates the impact of PTS transport on the product quality of two t...
Development and evaluation of sorafenib and curcumin co-loaded microemulsion gel for the management of breast cancer [0.03%]
开发和评价联合装载索拉非尼和姜黄素微乳凝胶用于乳腺癌的治疗及其评估
Md Abul Barkat,Afaf F Almuqati,Harshita Barkat et al.
Md Abul Barkat et al.
In this study, sorafenib (an established anticancer drug) and curcumin (a polyphenolic compound), both with numerous challenges like solubility, permeation, bioavailability, and dose-dependent toxicity, were co‑loaded in a microemulsion-ba...
A multi-dimensional modeling framework integrating metabolomics analysis and process modeling for bioprocess characterization [0.03%]
一个集成代谢组学分析和过程建模的多维模型框架，用于生物过程表征
Yingting Shi,Jingyu Jiao,Yuxiang Wan et al.
Yingting Shi et al.
Upstream bioprocess development relies heavily on design of experiment (DoE) and response surface methodology, which often focus on endpoint outcomes while overlooking the dynamic trajectories of cell culture processes. To overcome this lim...
Deng-Guang Yu,Cui He,Jingjing Feng et al.
Deng-Guang Yu et al.
Janus nanostructures are popular in a wide variety of applied scientific fields because they provide two adjacent sides to contact with environments. Thus, such structures can be facilely endowed with desired properties and functional perfo...