A stability-indicating green RP-HPLC method for single-run quantification of ten related substances and abrocitinib, a selective JAK1 inhibitor [0.03%]
一种绿色RP-HPLC稳定性指示方法同时测定阿布昔替尼及其十种有关物质的含量
Nagarjuna Rao Chintanippul,B Purna Chandra Rao,Anil Kumar Kanuri et al.
Nagarjuna Rao Chintanippul et al.
A robust stability-indicating green reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the quantitative analysis of abrocitinib and its ten related substances in accordance with green analy...
Reducing crack occurrence from frictive damage with externally coated pharmaceutical glass vials [0.03%]
具有外部涂层的制药玻璃小瓶可减少摩擦损伤并降低裂纹发生率
Alicia M Gallagher,James E Webb,Eric L Allington et al.
Alicia M Gallagher et al.
Handling of parenteral glass packaging introduces strength-limiting defects that can increase the likelihood of cracking and breakage. Cracking is particularly problematic because it is a critical defect that can compromise the sterility of...
Enhanced bioavailability of albendazole sulfoxide via binary solid dispersion: Preparation, characterization and goat pharmacokinetics [0.03%]
二元固态分散体系改善奥苯达唑砜口服吸收：制备、表征及药代动力学研究
Qindan Zuo,Mengxing Zhang,Yuan Zhu et al.
Qindan Zuo et al.
Albendazole sulfoxide (ABZSO), the pharmacologically active metabolite of albendazole, exhibits favorable tissue distribution but its pharmaceutical application is constrained by poor aqueous solubility. In this study, an optimized binary s...
Niclosamide ethanolamine induces malignant phyllodes tumor cell death via mTOR-TFEB axis-mediated lysosomal biogenesis and functional uncoupling [0.03%]
尼克洛氨乙醇胺通过mTOR-TFEB轴介导的溶酶体生物发生和功能解偶联诱导恶性叶状肿瘤细胞死亡
Xinyi He,Xu Jiang,Huazhong Lin et al.
Xinyi He et al.
Breast malignant phyllodes tumor (MPT) is a fibroepithelial neoplasm characterized by high recurrence rates. Currently, no effective therapeutic agents are available, and surgery remains the mainstay of treatment for MPT. Niclosamide ethano...
Neutrophil membrane-coated melanin nanoplatform: Targeted delivery of rapamycin and synergistic treatment of atherosclerosis [0.03%]
中性粒细胞膜涂覆的黑色素纳米平台：雷帕霉素的靶向递送及动脉粥样硬化的协同治疗
Qian Wang,Juan Zhang,Xinru Ma et al.
Qian Wang et al.
Chronic inflammation establishes a persistent pathogenic microenvironment within atherosclerotic plaques. Given the central role of neutrophils in atherogenesis and their inherent inflammatory tropism, we designed a biomimetic nanoplatform ...
Comment on "Nano-enabled targeted transdermal therapy for pain management in cervical cancer" [0.03%]
关于“纳米药物透皮治疗宫颈癌疼痛”的评论
Shubham Kamble,Gulshan Gurunani,Mitali Bodhankar
Shubham Kamble
Response to the Letter Regarding "Nano-enabled Targeted Transdermal Therapy for Pain Management in Cervical Cancer" [0.03%]
关于“纳米靶向透皮镇痛疗法在宫颈癌治疗中的应用”的回复信
Beatrice Odei-Mensah,Samson A Adeyemi,Yahya Essop Choonara
Beatrice Odei-Mensah
Elucidation of intermolecular interaction patterns in quaternary solid dispersion complexes of Enzalutamide [0.03%]
恩杂鲁胺四元固态分散复合物间的分子间相互作用模式的阐明
Shun Matsuzawa,Tatsuya Fukuta,Naoki Yoshihara et al.
Shun Matsuzawa et al.
Enzalutamide (ENZ) is commercially formulated as an amorphous solid dispersion (ASD) using a single polymer. This study investigated an alternative multicomponent ASD for ENZ to expand formulation options beyond single-polymer systems. Whil...
Pharmacokinetics and pharmacodynamics studies of different types of insulin with the canine euglycemic clamp [0.03%]
用正常糖钳法研究不同类型胰岛素的药代动力学和药效学
Difeng Zhu,Chao Chen,Chenxing Yuan
Difeng Zhu
Diabetes mellitus is a globally prevalent metabolic disorder with insulin therapy as its core intervention. Premixed insulins provide combined basal and prandial glucose control but lack systematic nonclinical validation of component intera...
In-die compressibility as a surrogate for lubrication-induced changes in tabletability [0.03%]
在模具中的可压缩性作为润滑引起的片剂性能变化的替代指标
Gian Mensch,Najeeb Abdelrahman,Stefan Klinken-Uth
Gian Mensch
Lubricants are indispensable in tableting, as their impact extends beyond facilitating ejection to altering compressibility and tablet strength. However, the extent to which lubrication affects in-die compressibility, and whether these effe...