Successful bioequivalence prediction of immediate-release vortioxetine tablets through prospective virtual crossover and parallel trials [0.03%]
通过前瞻性虚拟交叉和并行试验成功预测文拉法辛即释片的生物等效性
Dorota Danielak,Marcela Staniszewska,Svitlana Romanova et al.
Dorota Danielak et al.
We prospectively conducted virtual bioequivalence (VBE) trials under fasted conditions to guide a clinical trial design and candidate selection for a model drug with a long elimination half-life. We combined biopredictive dissolution method...
Targeted transdermal scopolamine delivery over the salivary glands for sialorrhea: Dose-response and systemic safety in rats [0.03%]
针对唾液腺的东莨菪碱透皮给药治疗流涎症：剂量反应及系统安全性研究（大鼠模型）
Natsuko Ishida,Koichi Takagaki,Mutsumi Urayama et al.
Natsuko Ishida et al.
Sialorrhea is a common and distressing symptom in patients with neurological disorders, often impairing quality of life and increasing the risk of aspiration. Although oral anticholinergic agents are widely prescribed, their systemic side e...
Sodium-activated Algerian bentonite with improved surface properties and topical barrier performance [0.03%]
具有改善的表面性能和皮肤屏障效果的钠激活的阿尔及利亚蒙脱石
Rania Chebani,Khedidja Tahar Djebbar,Kamel Daoud
Rania Chebani
This study investigates whether sodium activation can turn an under-utilized Algerian calcium bentonite into a topical barrier-oriented clay with measurable barrier-relevant performance in a model of inflammatory skin barrier dysfunction. R...
Developability assessments with four mRNA-LNP vaccine formulations comparing mouse immunogenicity, structural attributes, and stability profiles [0.03%]
四种mRNA-LNP疫苗配方的可开发性评估：比较小鼠免疫原性、结构特征和稳定性表征
Max Fairlamb,Ozan S Kumru,John M Hickey et al.
Max Fairlamb et al.
A standardized developability workflow to rank-order the stability profiles of mRNA-LNP vaccine formulations is described. As proof-of-concept, three experimental mRNA-LNP formulations with varying lipid compositions were benchmarked agains...
Long-acting injectable microsphere of crosslinked collagen encapsulates solid dispersion to enhance bioavailability of aripiprazole [0.03%]
交联胶原微球包封的艾司西酞普兰固态分散体系长效注射剂以提高生物利用度
Shanglun Li,Xiaoxuan Ji,Wei Huang et al.
Shanglun Li et al.
Aripiprazole (APZ) injectable formulations have been developed to address the poor patient compliance associated with its oral dosage forms for the long-term treatment of schizophrenia. However, the solubility of APZ decreases as the pH inc...
Development and characterization of allopurinol-loaded transethosomal gel for topical gout management [0.03%]
一种外用治疗痛风的别嘌醇载药透乙osomes凝胶的开发与表征
Iqra Safdar,Aqeedat Javed,Muhammad Usman et al.
Iqra Safdar et al.
Gout refers to the painful inflammation of the joints due to deposition of monosodium urate (MSU) cystals. Treatment of gout commonly involve a biopharmaceutical classification system (BCS) class IV drug, allopurinol (ALLP), which is a xant...
Biopolymer-stabilized zein nanoparticles for pressure ulcer management: Formulation, optimization, and preliminary in vivo assessment [0.03%]
用于压力性溃疡管理的生物聚合物稳定玉米谷蛋白纳米颗粒：配方、优化及初步体内评估
Yasmin E Emara,Wessam M El-Refaie,Maram M Allam et al.
Yasmin E Emara et al.
Pressure ulcers (PUs) remain a major healthcare burden, requiring innovative, safe, and effective therapies. Bioactive polysaccharide-based nanoplatforms offer promise owing to their biocompatibility, biodegradability, and wound-healing pot...
A novel in silico platform combining data-driven and physics-based models for protein formulation developability assessment [0.03%]
一种新型计算平台结合数据驱动和物理基础模型用于蛋白质配方开发性评估
Andrea Arsiccio,Kristian Le Vay,Andre Sao Pedro et al.
Andrea Arsiccio et al.
The development of novel therapeutic proteins is accompanied by huge financial and time investments. Advancing molecules through drug product development without proper scrutiny often leads to costly failures. In some cases, such failures a...
Cinnamon oil-driven lipid nanocarrier system for topical miconazole delivery: QbD-based development and characterization [0.03%]
基于QbD的脂质纳米载体系统用于局部递送麦珠子灰浆的肉桂油驱动研究与表征
Sarah I Bukhari,Rama Kharsa,Munirah Al Otaibi et al.
Sarah I Bukhari et al.
Lipid-based nanocarriers offer a promising approach to provide topical antifungal therapy through drug delivery enhancement and synergistic effect. Accordingly, the study was planned to develop a nano-lipid matrix incorporating an antifunga...
Impact of disintegrants on the structure and disintegration of hydroxypropyl methylcellulose-based amorphous solid dispersion tablets [0.03%]
崩解剂对羟丙甲纤维素共熔物无定型固体分散体制剂结构和溶出性能的影响研究
Natsuki Takahashi,Miho Inoue,Takayuki Terukina et al.
Natsuki Takahashi et al.
Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration delay after storage poses a significant challenge to formulation performance. This study investig...