Sadegh Poozesh,Mike Long,Robert Frederick Meyer et al.
Sadegh Poozesh et al.
The pharmaceutical industry is undergoing a significant digital transformation, with automation emerging as a central strategy to streamline drug product (DP) process development, reduce costs, and enhance operational efficiency. This paper...
Lyophilization of a viral vaccine: Strategies for surrogate use in analytical characterization of cake properties and considerations on virus infectivity [0.03%]
冻干病毒疫苗的冷冻干燥：用于分析表征产物特性策略及关于病毒感染性的考虑
Andrea Arsiccio,Felix Reuter,Sabine Ulamec et al.
Andrea Arsiccio et al.
Lyophilization has the potential to increase the stability of viral vectors and reduce the dependence on an uninterrupted cold chain. However, freezing and drying stress can inactivate viruses, resulting in reduced infectivity. Development ...
Response to comment on "A quantitative metric of immune responses with applications in vaccines, cancer immunity, autoimmunity, and anti-drug antibody monitoring" [0.03%]
关于“用于疫苗、癌症免疫、自身免疫和抗药物抗体监测的定量免疫反应度量”的评论答复
Indiwari Gopallawa,Surendra Chavan,Arvind Goswami et al.
Indiwari Gopallawa et al.
Rapamycin loaded lipid-polymer hybrid nanoparticles in a topical hydrogel for the treatment of psoriasis [0.03%]
雷帕霉素载脂质聚合物混合纳米粒在银屑病治疗中应用的凝胶基质中的负载研究
Samarth Bhargava,Abhay Tharmatt,Prabhjeet Singh et al.
Samarth Bhargava et al.
Lipid-Polymer Hybrid Nanoparticles (LPHNs) offer significant advantages in drug delivery systems due to their enhanced drug loading, controlled release, and stability. This study focuses on developing and evaluating Rapamycin-loaded LPHNs (...
Comment on "A quantitative metric of immune responses with applications in vaccines, cancer immunity, autoimmunity, and anti-drug antibody monitoring" [0.03%]
对“免疫反应的定量度量及其在疫苗、癌症免疫、自身免疫和抗药抗体监测中的应用”的评论
Shobana Chandrasekar,Rohith Krishn M K,Umesh Kumar
Shobana Chandrasekar
Evaluating hemicellulose-API miscibility using melting point depression [0.03%]
利用熔点降低法评估半纤维素-API的互溶性
Tuomas Kilpeläinen,Riikka Laitinen
Tuomas Kilpeläinen
To improve the solubility of poorly soluble APIs, amorphous solid dispersions (ASDs) are commonly employed. For an ASD to remain stable and effective, sufficient miscibility between the API and the polymeric carrier is essential. Although h...
Call for manuscript submissions on the applications of artificial intelligence in drug formulation and development [0.03%]
关于人工智能在药物配制和开发应用的手稿提交征求通知
Kenneth L Audus
Kenneth L Audus
Relating plaque psoriasis barrier function changes with the underlying skin morphology and physiology [0.03%]
银屑病斑块屏障功能变化与皮肤形态和生理的关系研究
Sean E Mangion,Joshua K Dalton,James F Clarke et al.
Sean E Mangion et al.
The relationships between skin barrier function and its morphology and physiology in disease states are poorly described in the literature. Such relationships may be useful in guiding decisions on topical drug development as they impact dru...
Understanding the impact of spray drying temperature on the dissolution behavior of a HPMC-AS spray dried formulation [0.03%]
喷雾干燥温度对羟丙基甲基纤维素乙酸琥珀酸盐喷雾干燥产品溶解行为影响的探究
Guangyu Ma,David Lavrich,Mark Schaefer et al.
Guangyu Ma et al.
Spray dried dispersion (SDD) is increasingly used in solid dose formulations for poorly soluble active pharmaceutical ingredients (APIs). Dissolution was studied on a HPMC-AS based SDD and one important SDD manufacturing parameter, the spra...
Beeswax sacrificial support and latex curing for high-fidelity semi-solid extrusion 3D printed sustained-release tablets [0.03%]
用于半固态挤出3D打印缓释片的蜂蜡牺牲支撑与橡胶模固化方法
Haozheng Zhang,Chuansheng Yang,Wenhao Yuan et al.
Haozheng Zhang et al.
Semi-solid extrusion (SSE) 3D printing offers significant potential for fabricating personalized oral dosage forms, thanks to its mild processing conditions. However, post-printing drying often induces structural collapse and deformation du...