A computationally informed framework for lipid-based formulation developability: Integrating predictive models with case studies [0.03%]
Callum D Ryan,Joseph P O&#x;Shea,Brendan T Griffin
Callum D Ryan
The increasing prevalence of poorly water-soluble drugs (PWSDs) in development pipelines has intensified the need for bio-enabling strategies such as lipid-based formulations (LBFs). However, formulation selection for optimal bioavailabilit...
Mahmoud Tawfieq,Christina Lene Schneider,Kalle Kællberg Westring Woller-Nielsen et al.
Mahmoud Tawfieq et al.
Photostability is a critical factor influencing the quality and safety of drug products. This study presents a novel method to assess the photostability of drug products under indoor LED lighting, complementing certain aspects of but also c...
Madeline Berrow,Nichola J Starr,David J Scurr et al.
Madeline Berrow et al.
The National Institute for Health and Care Excellence recommend the routine use of topically applied chlorhexidine digluconate (CHX) formulations to eliminate skin microorganisms prior to incision to prevent surgical site infections (SSI). ...
Mikayla L Rahman,Sijia Tao,Camryn Mekal et al.
Mikayla L Rahman et al.
Low adherence to daily oral drug regimens is a significant obstacle in effectively managing chronic therapies like HIV treatment, pre-exposure prophylaxis (PrEP), and contraception. While long-acting injectables eliminate the need for daily...
Dual-layer tissue scaffolds with antibacterial and regenerative properties: Integration of melt electrowriting and electrospray technologies [0.03%]
Irem Aydos,Sabereh Nouri,Sibel Daglilar et al.
Irem Aydos et al.
Efficient wound healing requires the design of advanced biomaterials that combine structural integrity, antimicrobial functionality, and the ability to promote tissue regeneration. The paper discusses the development of dual-layer tissue sc...
Multidisciplinary exploratory survey: Initial insights into biologic drug handling and regulatory perspectives among healthcare professionals [0.03%]
多学科探索性调查：生物药处置和监管视角的初步洞见——来自医护专业人员的观点
Léa Sorret,Nathalie Fuentes,Lara Nonis et al.
Léa Sorret et al.
Biologic drugs require specialized handling to maintain efficacy and safety, yet there is limited data on how healthcare professionals access information and comply with drug handling regulations. A 16-question survey was used to assess pro...
A quantitative metric of immune responses with applications in vaccines, cancer immunity, autoimmunity, and anti-drug antibody monitoring [0.03%]
一种免疫反应的量化指标及其在疫苗、癌症免疫、自身免疫和药物抗抗体监测中的应用
Indiwari Gopallawa,Surendra Chavan,Arvind Goswami et al.
Indiwari Gopallawa et al.
Advances in immunotherapies across cancer, vaccines, autoimmunity, and biologics have highlighted the critical need for comprehensive metrics that capture immune dynamics beyond traditional reductionist measures such as antibody levels, lym...
Comprehensive stress study on recombinant adeno-associated virus vectors: Evaluating the capabilities of established analytical techniques [0.03%]
重组腺相关病毒载体的全面应力研究：评估 established 分析技术的能力
Jakob Heckel,Lukas Bongers,David Naylor et al.
Jakob Heckel et al.
Recombinant adeno-associated virus (rAAV) vectors are prominent vectors for in-vivo gene therapies. However, achieving consistent product quality is a major challenge due to the inherent complexity of their structure and the associated prod...
Forced degradation analysis of recombinant adeno-associated virus serotype 8 based on analytical anion exchange chromatography coupled to orthogonal characterization [0.03%]
基于分析阴离子交换色谱与正交表征偶联的重组腺相关病毒八型强制降解研究
Zhuolun Yang,Yuki Yamaguchi,Xiaofang Lyu et al.
Zhuolun Yang et al.
As a leading vector for gene therapy, recombinant adeno-associated virus (rAAV) has been widely investigated and used. Forced degradation analysis is required to understand the molecular properties and stability of rAAV. In this study, we h...
Evaluation of DMSO extraction efficiency compared to other solvents on representative polymeric materials used in biologics production [0.03%]
评估DMSO与其他溶剂从生物药生产中使用的代表性聚合材料中提取的效率
Ting Cheng,Praveen Kumar,Noorunnisa Rasheed et al.
Ting Cheng et al.
Single-use systems (SUS) are increasingly employed in biopharmaceutical manufacturing, including advanced therapy medicinal products (ATMP) and antibody-drug conjugates (ADC). Dimethyl sulfoxide (DMSO), commonly used at 5-10 % in cell and g...