Comment on "Improved Sub-Visible Particle Classification in Flow Imaging Microscopy via Generative AI-Based Image Synthesis" [0.03%]
关于“基于生成AI的图像合成改进流式成像显微镜下的亚可见粒子分类”的评论
V Senthilkumar,Pratik Mungekar,R Vasanthan
V Senthilkumar
Mechanistic advances in nanomedicine, nucleic acid therapies, and AI-driven research on cervical cancer [0.03%]
纳米医学、核糖核酸治疗及人工智能驱动的宫颈癌研究新进展
Manoj Dalabehera,Shubham Chaudhari,Jatin Kumar et al.
Manoj Dalabehera et al.
Cervical cancer pharmacotherapy is significantly limited by physiological and cellular barriers that restrict drug access to therapeutic targets, resulting in suboptimal biodistribution, systemic toxicity, and the emergence of drug resistan...
Rational design, expression and refolding of a novel bispecific antibody to simultaneously target VEGF-A and Ang-2 for inhibition of angiogenesis [0.03%]
一种新型的双特异性抗体的理性设计、表达和复性使其同时靶向VEGF-A和Ang-2以抑制血管生成
Elahe Pishgahzadeh,Ladan Mafakher,Sara Dabirian et al.
Elahe Pishgahzadeh et al.
Bispecific antibodies simultaneously targeting vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2) represent a promising anti-angiogenic strategy in cancer therapy. Tandem single-chain bispecific antibodies (scBsAbs) of...
Formulation development and evaluation of nasal in situ gel of promethazine hydrochloride- part II: Pharmacokinetic evaluation and bioavailability studies [0.03%]
氯化/promethazine鼻用在体凝胶制剂的开发与评价（二）：药动学研究及生物利用度研究
Surabhi H Patil,Sanjay B Patil
Surabhi H Patil
Promethazine hydrochloride, a first-generation H1 receptor blocking agent, possesses antimuscarinic, sedative, and serotonin antagonistic properties. It is widely used as an antiemetic for treating nausea and vomiting caused by motion sickn...
PEG-g-(HEMA-co-AA) pH-responsive graft copolymer: A promising approach for the controlled oral delivery of acid-labile rabeprazole sodium [0.03%]
具有pH响应性的聚乙二醇共接枝物(HEMA-co-AA)：雷贝拉唑钠的控制口服传递的良好策略
Ume Ruqia Tulain,Nadia Shamshad Malik,Alia Erum et al.
Ume Ruqia Tulain et al.
This research presents the development of a novel pH-sensitive PEG (HEMA-co-AA) graft copolymer hydrogel designed to provide controlled and protective delivery of acid-labile drugs, specifically Rabeprazole sodium. The hydrogel was synthesi...
Efficacy of ultraviolet irradiation of pharmaceutical excipients in mitigating N-nitrosamine generation [0.03%]
紫外线照射药用辅料以降低亚硝胺生成的效能研究
Saki Minamioka,Shun Matsuzawa,Naoki Yoshihara et al.
Saki Minamioka et al.
The generation of N-nitrosamine compounds (NOCs) in drugs presents a critical regulatory challenge owing to their potential mutagenicity and exceptionally strict acceptable intake limits required for patient safety. These impurities arise p...
Design of poly(jasmine lactone) micelles for enhanced delivery of remdesivir as a substitute for β-cyclodextrin formulations [0.03%]
聚茉莉酸丁内酯胶束的合成用于增强瑞德西韦药物的递送性能以替代β-环糊精包合物
Jyoti Verma,Fanny Frejborg,Pekka Kolehmainen et al.
Jyoti Verma et al.
Remdesivir (REM), a nucleoside analogue that has been approved for SARS-CoV-2 treatment, is poorly soluble in water and is currently administered intravenously formulated with sulfobutylether-β-cyclodextrin (SBECD) to facilitate solubiliza...
Integrating nitrosamine theoretical formation into Translational Pharmaceutics: Mitigating risks during accelerated formulation development in early phase clinical studies [0.03%]
论翻译药学中的亚硝胺理论生成：在早期临床试验中加快制剂开发过程时降低风险
Diego Cobice,Vinay Mamidala,Rachel Quick et al.
Diego Cobice et al.
Nitrosamine impurities, owing to their established carcinogenic potential, represent a significant challenge in contemporary pharmaceutical development. Regulatory expectations have evolved rapidly, with stringent requirements for their ide...
Bioadhesive pH-responsive chitosan-dextran nanoparticles for controlled trimethoprim delivery in urinary tract infections [0.03%]
用于控制泌尿道感染的 TMP 递送的生物粘附性 pH 响应型壳聚糖-右旋糖酐纳米粒子
Yanlin Wu,Xiaolong Zhang,Guangjing Mu et al.
Yanlin Wu et al.
The globally affected Urinary Tract Infections (UTI) is caused by resistant uropathogens, formation of biofilms, and intracellular persistence. In the present study, chitosan-dextran nanoparticles that are bioadhesive in nature were prepare...
Salbutamol sulfate and budesonide inhalation suspension for inhalation therapy: In vivo and in vitro evaluation [0.03%]
盐酸沙丁胺醇和布地奈德吸入溶液的临床与体外评价研究
Chao Zhang,Yunqi Bi,Zengming Wang et al.
Chao Zhang et al.
Nebulized inhalation therapy is widely used for the treatment of acute exacerbations of asthma and COPD, in which budesonide (BUD) and salbutamol sulfate (SA) are commonly combined for synergistic anti-inflammatory and bronchodilatory effec...