Development of novel lamellar nanoparticle formulation using arginine-β-branched hexyldecyl phosphate for dermal delivery of pyridoxine dicaprylate [0.03%]
一种新型精氨酸-侧链含十六醇磷酸酯纳米片状结构表皮药物传递体系递送维生素B6二硬脂酸酯的研究
Ikumi Suzuki,Tomonobu Uchino,Ichiro Hatta et al.
Ikumi Suzuki et al.
This study aimed to develop novel lamellar nanoparticles (NP) using arginine-β-branched hexyldecyl phosphate (AHP) for dermal delivery of pyridoxine dicaprylate (PDC). NPs were prepared via the film rehydration method, and the effects of t...
Characterization, in vitro release, and pharmacokinetics of rupestonic acid derivative nanostructured lipid carriers optimized by Box-Behnken design [0.03%]
Box-Behnken设计优化的鲁皮松酸衍生物纳米结构脂质载体的表征、体外释放及药动学研究
Xin Fan,Xin Wang,Shuyan Han et al.
Xin Fan et al.
This study aimed to enhance the oral bioavailability of the rupestonic acid derivative CAM106 by developing nanostructured lipid carriers (NLCs) as its delivery system. CAM106-NLCs were prepared via the organic solvent evaporation method, w...
Navigating PUPSIT implementation challenges for high-viscosity oligonucleotide drug products [0.03%]
高粘度寡核苷酸药物产品的PUPSIT实施挑战及应对策略
Yu Zoe Zhang,Joseph Perchiacca,Anya Batalina et al.
Yu Zoe Zhang et al.
The implementation of the revised European Union (EU) EMA Annex 1 (effective August 2023) has introduced stricter requirements for the design and operation of sterile injectable manufacturing processes. Among these requirements, Pre-Use Pos...
N-Nitrosamine Formation in Pharmaceutical Drug Products: Development and Validation of a Biased, Conservative, Predictive Model [0.03%]
药物产品中N-亚硝胺形成的开发和验证一种偏倚的、保守的、预测模型
Ian W Ashworth
Ian W Ashworth
Following the discovery of N-nitrosamines in a range of medicinal products, regulatory agencies have required marketing authorization holders to undertake risk assessments for the presence of N-nitrosamines in their drug products. This work...
Assessment of intranasal permeability and pharmacological activity of glyburide-loaded nanosuspension formulation for Alzheimer's disease [0.03%]
甘丝停纳米悬浮液制剂治疗阿尔茨海默病的鼻黏膜通透性及药理活性评估
Damla Gungor,Semsi Muratoglu,Eren Aytekin et al.
Damla Gungor et al.
Glyburide is an anti-diabetic drug with promising potential implications for Alzheimer's disease. This study evaluated the permeability and activity of glyburide via intranasal administration in Alzheimer's disease using both in vivo and ex...
Lipid-free, thermostable mRNA vaccines prepared using atomic layer deposition [0.03%]
利用原子层沉积制备的无脂质、热稳定的mRNA疫苗
Holly J Coleman,Amber Rauch,Erika Langsfeld et al.
Holly J Coleman et al.
Lipid nanoparticle (LNP) formulations of mRNA vaccines have played a pivotal role in combatting SARS-CoV-2 infections and are expected to be a useful vaccine modality against other pathogens. However, the instability of mRNA-LNP vaccines re...
Phosphatidylserine blockade by dipicolylamine-zinc enhances chemoimmunotherapy of B16F10 melanoma [0.03%]
二乙醇胺锌通过诱导铁死亡增强PSO介导的黑色素瘤化疗免疫治疗的效果研究
Jianping Wang,Fanfei Meng,Ziang Chen et al.
Jianping Wang et al.
In cancer therapy, chemotherapy and immunomodulatory agents are often combined to leverage their complementary mechanisms. Chemotherapeutic drugs promote the release of tumor antigens in situ, enhancing immune recognition, whereas immunosti...
Investigation on the contribution of self-assembled bile salt micelles in the intestinal tract to the synergistic absorption of medicine [0.03%]
胆盐微团在肠道中对药物协同吸收的贡献研究
Ting Le,Su Wang,Mian Zhao et al.
Ting Le et al.
Bile salt vesicles (BSVs) are phases formed by the self-assembly of bile salts and phospholipids in the intestinal endogenous environment, which play a crucial role in the absorption of insoluble components. Reciprocal absorption of drug pa...
Chemical instability of cefaclor in simple suspensions alkalinized with magnesium oxide and the structural elucidation of the degradation products [0.03%]
氧化镁调节pH值的头孢克洛混悬液中的化学不稳定性和降解产物的结构阐明
Ginjiro Kato,Hidemichi Mitome,Mitsuki Yamanaka et al.
Ginjiro Kato et al.
A simple suspension method, where solid formulations are soaked in water (55°C) and suspended followed by tube administration, has been widely used in Japan for patients with dysphagia. However, information on the chemical stability of dru...
Design and Evaluation of Diacerein-Loaded Oleoliposome Dry-Powder Inhalation Nano-Formulation for Targeted Anti-Inflammatory Therapy in COPD [0.03%]
设计和评估用于慢性阻塞性肺病靶向抗炎治疗的载有二春精的油脂质体干粉吸入纳米制剂及其评价研究
Khaled Almansour,Amira A Boseila,Ahmed A Katamesh et al.
Khaled Almansour et al.
Background & objective: Chronic obstructive pulmonary disease (COPD) is accompanied by chronic bronchitis and emphysema; current inhaled therapies suffer from short half-life, poor lung deposition, and corticosteroid resi...