Investigating the Correlation Between Drug Physical Properties and Physical Characteristics and Drug Entrapment Efficiencies of Chitosan-TPP Nanoparticles [0.03%]
壳聚糖-TPP纳米颗粒物理性质和物理特征与药物包封率的相关性研究
Abdolelah Jaradat,Wasfy M Obeidat
Abdolelah Jaradat
Chitosan nanoparticles (NPs) have been the subject of intensive research. This study aimed to determine how different drug characteristics such as molecular weights, drug solubility in the processing medium, and drug ionization/charge state...
Vaporized Hydrogen Peroxide Sterilization in the Production of Protein Therapeutics: Uptake and Effects on Product Quality [0.03%]
蛋白药物生产中过氧化氢蒸汽灭菌法的应用及其对产品质量的影响
Michael Meleties,Bailey M Cooper,Daniela Marcano-James et al.
Michael Meleties et al.
The aseptic filling of drug products is carried out in pharmaceutical isolators that have been sterilized. A commonly used method for achieving a high level of sterility assurance is vaporized hydrogen peroxide (VHP) sterilization, which is...
Accelerating Full-Thickness Wound Healing with Bacterial Cellulose-Based Multilayer Composites [0.03%]
基于细菌纤维素的多层复合材料加速全层伤口愈合
Homa Mohaghegh,Zahra Assadi,Amin Derakhshan et al.
Homa Mohaghegh et al.
Materials that speed up wound healing can be of great benefit to patients and healthcare providers. One-layer dressings, however, have unsatisfactory healing efficacy since it is impossible to use materials with different properties simulta...
Utility of Coproporphyrin-I Determination in First-in-Human Study for Early Evaluation of OATP1B Inhibitory Potential Based on Investigation of Ensitrelvir, an Oral SARS-CoV-2 3C-Like Protease Inhibitor [0.03%]
基于恩司特韦研究早期评估OATP1B抑制潜力的粪便原卟啉I测定的效用首次人体试验
Ryosuke Watari,Hiromi Sawada,Hiroshi Hashimoto et al.
Ryosuke Watari et al.
Coproporphyrin-I (CP-I) has been investigated as an endogenous biomarker of organic anion transporting polypeptide (OATP) 1B. Here, we determined the CP-I concentrations in a cocktail drug-drug interaction (DDI) study of ensitrelvir to eval...
Karoline Bechtold-Peters,Andrea Ruggiero,Nienke Vriezen et al.
Karoline Bechtold-Peters et al.
Antibody-drug conjugates unite the specificity and long circulation time of an antibody with the toxicity of a chemical cytostatic or otherwise active drug using appropriate chemical linkers to reduce systemic toxicity and increase therapeu...
A Survey on Handling and Administration of Therapeutic Protein Products in German and Swiss Hospitals [0.03%]
德国和瑞士医院治疗蛋白质产品的管理概况调查研究报告
Maximilian Wozniewski,Ahmed Besheer,Jörg Huwyler et al.
Maximilian Wozniewski et al.
Protein products in hospitals often have to be compounded before administration to the patient. This may comprise reconstitution of lyophilizates, dilution, storage, and transport. However, the operations for compounding and administration ...
Plasma Protein Binding Determination for Unstable Ester Prodrugs: Remdesivir and Tenofovir Alafenamide [0.03%]
不稳定的酯型前药的血浆蛋白结合率测定：瑞德西韦和恩曲他滨阿尔法狄夫盐酸盐的例子
Anita Wen,Ann Ran-Ran Qin,Thomas Tarnowski et al.
Anita Wen et al.
Remdesivir (RDV) and tenofovir alafenamide (TAF) are prodrugs designed to be converted to their respective active metabolites. Plasma protein binding (PPB) determination of these prodrugs is important for patients with possible alteration o...
Does Aggregation of Therapeutic IgGs in PBS Offer a True Picture of What Happens in Models Derived from Human Body Fluids? [0.03%]
人源化体内模型中免疫球蛋白G(IgG)聚集行为的PBS溶液标定方法适用性研究
Shravan Sreenivasan,Sanjeet S Patil,Anurag S Rathore
Shravan Sreenivasan
Therapeutic proteins such as monoclonal antibodies (mAb) are known to form aggregates due to various factors. Phosphate buffered saline (PBS), human serum, and human serum filtrate (HSF) are some of the models used to analyze mAb stability ...
A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, Linagliptin [0.03%]
一种关于肠泌素激素GIP和GLP1、胰高血糖素、葡萄糖、胰岛素以及小分子DPP-4抑制剂林西肽的定量系统药理学模型
Nan Wu,Guohua An
Nan Wu
In the current study, we established a comprehensive quantitative systems pharmacology (QSP) model using linagliptin as the model drug, where drug disposition, drug intervention on dipeptidyl peptidase-4 (DPP-4), glucose-dependent insulinot...
Solid Forms of The New Antitrypanosomal 1-(4-Acetamide-Benzenesulfonyl)-Benzimidazole: Preparation and Physicochemical Characterization [0.03%]
新型抗锥虫化合物1-（4-乙酰胺苯磺酰基）-苯并咪唑的固体形式：制备和物化性质表征
Marina M Marcos Valdez,Octavio E Fandiño,Sonia N Faudone et al.
Marina M Marcos Valdez et al.
This study aimed to investigate the polymorphism of 1-(4-acetamide-benzenesulfonyl)-benzimidazole (PABZI), a newly developed compound with significant activity against Trypanosoma cruzi, the parasite which causes American trypanosomiasis (C...