Purification and Activity Evaluation of a Novel Thrombopoietin Mimetic Peptide [0.03%]
一种新型血小板生成素拟肽的纯化及活性评价研究
Yimiao Liang,Yang Li,Rui Ma et al.
Yimiao Liang et al.
The emergence of thrombopoietin mimetic peptides presents a promising therapeutic strategy for addressing thrombocytopenia. This particular study aimed to establish a direct, expeditious, and efficient method for modifying and purifying a n...
Ternary Dry Powder Agglomerate Inhalation Formulation of Melatonin With Air Jet Mixing to Improve In Vitro And In Vivo Performance [0.03%]
一种三元干粉聚集体吸入制剂及其气流混合工艺以改善体内体外性能（以褪黑素为实例）
Qingzhen Zhang,Shanglong Kou,Yingtong Cui et al.
Qingzhen Zhang et al.
An improved agglomerate formulation with melatonin and fine lactose for dry powder inhalation using Turbuhaler® was developed. Co-grinding lactose with 1 % magnesium stearate prior to air jet mixing served as a key factor to improve the in...
Identification of Novel and Early Biomarkers for Cisplatin-induced Nephrotoxicity and the Nephroprotective Role of Cimetidine using a Pharmacometabolomic-based Approach Coupled with In Vitro Toxicodynamic Modeling and Simulation [0.03%]
基于药理代谢组学的方法结合体外毒动力学模型与计算机模拟鉴定顺铂致肾毒性的新型早期生物标志物及西米替丁的肾保护作用研究
Hardik Mody,Sreenath Nair,Adrian Rump et al.
Hardik Mody et al.
Cisplatin is widely used for the treatment of various types of cancer. However, cisplatin-induced nephrotoxicity (CIN) is frequently observed in patients receiving cisplatin therapy which poses a challenge in its clinical utility. Currently...
Porous Starch-inulin Loaded Quercetin Microcapsules: Characterization, Antioxidant Activity, in-vitro Release, and Storage Stability [0.03%]
多孔含壳聚糖/明胶的芦丁微胶囊化淀粉-菊粉小球：结构特性，抗氧化性，体外释放及储藏稳定性研究
Zahra Davoudi,Mohammad Hossein Azizi,Mohsen Barzegar et al.
Zahra Davoudi et al.
Quercetin (Q) has many potential health benefits, but its low stability limits its use in functional foods and pharmaceuticals. The low stability of quercetin is a challenge that needs to be addressed to fully realize its therapeutic potent...
Filling Unit Operation for Biological Drug Products: Challenges and Considerations [0.03%]
生物药品灌装工艺的挑战及考虑因素
Michael Adler,Andrea Allmendinger
Michael Adler
One of the key unit operations during the aseptic fill-finish process of parenteral products, such as biologics, is the filling process of the formulated, sterile filtered drug substance into primary packaging containers. The applied fillin...
Characterization of Silicone from Closed System Transfer Devices and its Migration into Pharmaceutical Drug Products [0.03%]
封闭系统转运装置中的硅胶特征及其向药物产品的迁移研究
Maximilian Wozniewski,Ahmed Besheer,Ahmad S Sediq et al.
Maximilian Wozniewski et al.
Closed System Transfer Devices (CSTDs) are increasingly used in healthcare settings to facilitate compounding of hazardous drugs but increasingly also therapeutic proteins. However, their use may significantly impact the quality of the ster...
Use of Closed System Transfer Devices (CSTDs) with Protein-Based Therapeutic Drugs-A Non-Solution for a Non-Problem? [0.03%]
封闭系统转输装置(CSTD)用于蛋白质类药物的问题与对策？非问题的非解方案？
Jonas Fast,Twinkle Christian,Mirjam Crul et al.
Jonas Fast et al.
Marshall S Padilla,Montira Tangsangasaksri,Chih-Chun Chang et al.
Marshall S Padilla et al.
In this study, an oil-in-water (o/w) nanoemulsion is used to deliver siRNA targeting Twist1, a protein that contributes to tumor metastasis in a variety of cancers. The FDA-approved oil, medium chain triglycerides (MCT), is used as the hydr...
Incorporation of Loratadine-Cyclodextrin Complexes in Oral Thin Films for Rapid Drug Delivery [0.03%]
洛拉替丁-环糊精包合物在口腔薄膜中的应用以实现快速药物传递
Annika Yardy,Kirsten Entz,Dayna Bennett et al.
Annika Yardy et al.
Rapidly dissolving polymer thin films, or oral thin films (OTFs), have recently emerged as an improved oral drug delivery vehicle with its ability to bypass liver first pass metabolism, longer shelf-life, and simpler transport and distribut...
Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers [0.03%]
肾上腺素受体激动剂对P-糖蛋白功能调节的可能作用：离体大鼠空肠片和Caco-2单层细胞的研究
Hironori Mukai,Masashi Takanashi,Ken-Ichi Ogawara et al.
Hironori Mukai et al.
To clarify the regulation of drug absorption by the enteric nervous system, we investigated how adrenergic agonists (adrenaline (ADR), clonidine (CLO), dobutamine (DOB)) and dibutyryl cAMP (DBcAMP) affected P-glycoprotein (P-gp) function by...