Solubility-Permeability Interplay in Facilitating the Prediction of Drug Disposition Routes, Extent of Absorption, Food Effects, Brain Penetration and Drug Induced Liver Injury Potential [0.03%]
溶出和渗透性对药物转运途径、吸收程度、食物影响、脑部穿透及药物诱导肝损伤潜能预测的协同作用
Leslie Z Benet
Leslie Z Benet
Here I detail the use of measures of permeability rate and solubility in predicting drug disposition characteristics through the utilization of the Biopharmaceutics Drug Disposition Classification System (BDDCS) and the Extended Clearance C...
A Study of Microemulsion Systems for Transdermal Delivery of Risperidone Using Penetration Enhancers [0.03%]
透皮吸收 enhancer 促渗剂提升利培酮 microemulsion 微乳体系透皮研究
Amitkumar Virani,Nirali Dholaria,Namrata Matharoo et al.
Amitkumar Virani et al.
The aim of this study was to develop and characterize microemulsion formulations using penetration enhancers as potential transdermal delivery systems for risperidone. Initially, a simple formulation of risperidone in Propylene Glycol (PG) ...
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases [0.03%]
利用药物代谢动力学和药物效应动力学生物标志物指导MTBT1466A首次人体起始剂量选择：一种用于治疗纤维化疾病的新型人源化单克隆抗TGFβ3抗体
Rajbharan Yadav,Siddharth Sukumaran,Jeff Lutman et al.
Rajbharan Yadav et al.
MTBT1466A is a high-affinity TGFβ3-specific humanized IgG1 monoclonal antibody with reduced Fc effector function, currently under investigation in clinical trials as a potential anti-fibrotic therapy. Here, we characterized the pharmacokin...
Optimization and Validation of a Liquid Formulation for a New Recombinant Veterinary Product using QbD Approach [0.03%]
基于QbD的新重组兽用制品液体制剂的优化与验证
María Celeste Rodríguez,Javier Villarraza,María Belén Tardivo et al.
María Celeste Rodríguez et al.
Protein formulation and drug characterization are one of the most difficult and time-consuming tasks because of the complexity of biotherapeutic proteins. Hence, maintaining a protein drug in its active state typically requires preventing c...
Image Classification of Degraded Polysorbate, Protein and Silicone Oil Sub-Visible Particles Detected by Flow-Imaging Microscopy in Biopharmaceuticals Using a Convolutional Neural Network Model [0.03%]
基于流动成像显微镜的生物药用多聚山梨醇酯、蛋白和硅油亚可见颗粒的卷积神经网络图像分类模型研究
Filip M Fedorowicz,Pascal Chalus,Kyra Kirschenbühler et al.
Filip M Fedorowicz et al.
Degradation of polysorbates in biopharmaceutical formulations can induce the formation of sub-visible particles (SvPs) in the form of free-fatty acids (FFAs) and potentially protein aggregates. Flow-imaging microscopy (FIM) is one of the mo...
A Novel Technique to Assess Drug Substance Particle Size in a Complex Inhaled Formulation [0.03%]
一种评估复杂吸入制剂中药物粒子大小的新技术
Daniel P Dobson,Miguel Saggu,Jackson D Pellett et al.
Daniel P Dobson et al.
Dry powder inhalers, comprising an active pharmaceutical ingredient (API) and carrier excipients, are often used in the delivery of pulmonary drugs. The stability of the API particle size within a formulation blend is a critical attribute f...
Jane Pf Bai,Jie Wang,Yifei Zhang et al.
Jane Pf Bai et al.
Though hundreds of drugs have been approved by the US Food and Drug Administration (FDA) for treating various rare diseases, most rare diseases still lack FDA-approved therapeutics. To identify the opportunities for developing therapies for...
Herbal Extracts Encapsulated Nanoliposomes as Potential Glucose-lowering Agents: An in Vitro and in Vivo Approach Using Three Herbal Extracts [0.03%]
三种草药提取物的体内外研究：纳米脂质体包裹的草药提取物作为潜在的降糖剂
Akurange Sujeevi Dammadinna Wickramasinghe,Anoja Priyadarshani Attanayake,Pabasara Kalansuriya
Akurange Sujeevi Dammadinna Wickramasinghe
Encapsulation of polyphenol-rich herbal extracts into nanoliposomes is a promising strategy for the development of novel therapeutic agents against type 2 diabetes mellitus. An attempt was made to encapsulate aqueous, ethanol, and aqueous e...
Importance of Kv Distribution in Freeze Drying Part I: A Holistic Model to Predict Changes in Kv Bimodal Distribution as a Function of Pressure [0.03%]
冻干中Kv分布的重要性（第一部分）：预测压力变化对双峰Kv分布影响的全面模型
Lauren Fontana,Mostafa Nakach,Benoit Koumurian et al.
Lauren Fontana et al.
Measurement of heat transfer coefficients (Kv) is an important part of freeze-dryers characterization and as well a necessary step for executing any modelling. In most cases only an average value of Kv is calculated, or an average value of ...
Prediction of the Time to Reach Equilibrium for Improved Estimation of the Unbound Fraction of Compounds in Equilibrium Dialysis Using kinetic Modeling [0.03%]
应用动力学模型预测达到平衡所需时间以提高平衡透析法测定化合物未结合分数的估计精度
Chan Bae,Gujin Chung,Suk-Jae Chung
Chan Bae
Equilibrium dialysis (ED) is widely used in pharmacokinetics to determine the fraction of unbound (fu) compounds in plasma; however, the kinetics of drugs in the ED system with respect to their permeation across semi-permeable membranes has...