Dissolving microneedles enable effective transdermal delivery of vitamin B12 and reduce endothelial inflammation [0.03%]
可溶性微针能使有效的经皮递送维生素B12并减少内皮炎症
Mandeep Marwah,Emmanuella Jumbo,Pavanjeeth Balakrishnan et al.
Mandeep Marwah et al.
Vitamin B12 deficiency is a significant clinical concern, often leading to pernicious anaemia and associated vascular dysfunction. Traditional supplementation methods face challenges such as poor absorption in patients lacking intrinsic fac...
Favipiravir-Levofloxacin salt reaction and its impact on the physicochemical properties [0.03%]
favipiravir-左氧氟沙星盐的相互作用及其对物理化学性质的影响
Ilma Nugrahani,Yefinadya Muharrifani,Marlia Singgih Wibowo et al.
Ilma Nugrahani et al.
Antivirals are often combined with antibiotics to treat infectious diseases, yet studies on their multicomponent systems remain limited. This experiment aimed to develop a multicomponent system combining the antiviral favipiravir (FAV) and ...
Letter to the editor regarding "Investigation of CT imaging-based Bi2S3 drug-loaded nanoparticles for the diagnosis and therapy of colorectal cancer" [0.03%]
关于“基于CT成像的Bi2S3载药纳米颗粒在结直肠癌诊断和治疗中应用研究”的来信
Hesam Nozari,Ali Zare,Ali Hosseini
Hesam Nozari
Differential effects of osmotic fluid dynamics on intestinal drug absorption between juvenile and adult rats: potential impact on drug interaction with hyperosmotic beverages [0.03%]
渗透流体动力学对幼年和成年大鼠肠道药物吸收的差异影响及其与高渗饮料相互作用的潜在影响
Kazuki Hotta,Tomoki Ishii,Asuka Kichijima et al.
Kazuki Hotta et al.
We previously reported that beverage-drug interactions can be partly explained by osmotic fluid secretion, leading to drug dilution in the intestine, using adult (8-week-old) rats. In this study, age-related differences in osmolality-depend...
HS15-based nanotherapeutics for direct nose-to-brain delivery against central nervous system fungal [0.03%]
用于中枢神经系统真菌感染的鼻脑递送纳米药物
Gaoshuo Zhang,Xingwang Ji,Wei Zhang et al.
Gaoshuo Zhang et al.
Amphotericin B (AmB) is a broad-spectrum antifungal drug, but its use in the treatment of fungal infections in the central nervous system (CNS) has been limited by the constraints of the blood-brain barrier (BBB) and the severe toxicity of ...
Evaluation of co-amorphous systems containing ritonavir and coformers: An experimental and molecular simulation study [0.03%]
含利托那韦和赋形剂的共无定形体系的评价：实验与分子模拟研究
Arif Budiman,Ai Syipa Ulfah Paujiah,Taufik Muhammad Fakih et al.
Arif Budiman et al.
This study investigates the role of saccharin (SAC) and nicotinamide (NIC) as co-formers in the formulation of ritonavir (RTV) using two different preparation methods: melt-cooling and solvent evaporation via experimental and computational ...
Dual strategy to enhance domperidone dissolution: mechanochemically synthesized multicomponent salts in orodispersible tablets [0.03%]
用于口崩片的机械化学合成多元复合盐增强多潘立酮溶解度的双重策略
Kassius de Souza Reis,Bruno Arantes Borges,Ana Carolina Marioto Santos et al.
Kassius de Souza Reis et al.
The pharmaceutical ingredient domperidone (DOM) acts as a prokinetic and antiemetic agent, commonly indicated for the treatment of gastroparesis, epigastric pain, reflux, and nausea. Its clinical efficacy, however, is limited by poor water ...
Exploring manganese-loaded nanoparticle formulations as contrast agents: A comprehensive in vitro and in vivo study [0.03%]
一种锰载纳米颗粒造影剂的体内和体外全面研究
Maide Öztürk Dalkılınç,Melih Zeki Kaya,Meltem Karataş et al.
Maide Öztürk Dalkılınç et al.
Magnetic Resonance Imaging (MRI) is a crucial diagnostic modality in modern medical practice, offering non-invasive insight into internal structures and functions of the human body. The development of MRI contrast agents has significantly i...
Thermosensitive in-situ gel based on halloysite nanotube/chitosan for site-specific delivery of aceclofenac [0.03%]
基于高岭土纳米管/壳聚糖的阿西美辛定点释放示温凝胶剂
Souvik Singha,Melbha Starlin Chellathurai,Syed Mahmood et al.
Souvik Singha et al.
Periodontitis, a severe and chronic inflammatory gum disease, necessitates the development of advanced drug delivery strategies due to the limitations of conventional therapies, such as rapid drug clearance and inadequate site-specific rete...
Corrigendum to Practical Estimation of Amorphous Solubility Enhancement Using Thermoanalytical Data: Determination of the Amorphous/Crystalline Solubility Ratio for Pure Indomethacin and Felodipine [Journal of Pharmaceutical Sciences] Volume 105, Issue 9, September 2016, Pages 2625-2630 [0.03%]
关于用热分析数据实践估计无定形溶解度增强的校正：纯吲哚美辛和非洛地平的无定形/结晶溶解度比率的确定校正[J].药物科学杂志]卷105，期9，2016年9月，页2625-2630
Peter J Skrdla,Philip D Floyd,Philip C Dell&#x;orco
Peter J Skrdla
Published Erratum
Journal of pharmaceutical sciences. 2026 Feb 26:104227. DOI:10.1016/j.xphs.2026.104227 2026