Biowaiver monograph for immediate-release solid oral dosage forms: Amlodipine Besylate [0.03%]
贝那普利口服固体制剂 Immediate-Release 药物 waivers 的生物等效性豁免评估报告
Porfirio de la Cruz Cruz,Mauricio A García,José Trinidad Pérez Urizar et al.
Porfirio de la Cruz Cruz et al.
Amlodipine besylate is a calcium channel blocker widely used for treating hypertension and coronary artery disease. This biowaiver monograph evaluates the suitability of BCS-based biowaivers for immediate-release (IR) oral dosage forms cont...
Combinatorial therapeutic effect of liposomes in inhibiting prostate cancer aggressiveness and targeting cancer-associated fibroblast [0.03%]
脂质体组合治疗抑制前列腺癌侵袭性并靶向癌症相关成纤维细胞的效果
Natsorn Watcharadulyarat,Paweena Dana,Prattana Tanyapanyachon et al.
Natsorn Watcharadulyarat et al.
Prostate cancer has the second-highest incidence cancer and is the fifth leading cause of mortality in males. Cancer-associated fibroblasts (CAFs), the abundant stromal cells in the tumor microenvironment (TME), play vital roles in secretin...
Development of a biocompatible CuO-ZnO nanocomposite for targeting of Chloramphenicol with enhanced antibacterial and anti-biofilm efficacy [0.03%]
一种生物相容的CuO-ZnO纳米复合材料的开发，用于增强氯霉素抗菌和抗生物被膜功效的靶向输送
Moupiya Ghosh,Dhritishree Ghosh,Shrabani Paul et al.
Moupiya Ghosh et al.
The extensive use and adverse side effects of standard antibiotics have imposed challenges for therapeutic treatment. Multi-drug resistant (MDR) pathogens need much higher concentrations of antimicrobial drugs, which kill the beneficial mic...
Dual statistical modeling using Box Behnken and D-optimal designs for optimization of indocyanine green conjugated silver nanoparticles and improvement of their associated photothermal therapy for application in wound healing [0.03%]
使用Box Behnken和D-最优设计的双统计模型优化吲哚菁绿偶联银纳米颗粒及其光热疗法在伤口愈合中的应用改良
Sarah Salah Thabet,Mona Morsy,Roxane Abdel-Gawad
Sarah Salah Thabet
This work focuses on preparing indocyanine green (ICG) conjugated silver nanoparticles (AgNPs) for wound management; making use of AgNPs antimicrobial and wound healing capabilities that improve and synergize the photothermal based healing ...
Development and characterization of low molecular weight heparin-triethanolamine cream: Skin permeability and antithrombotic efficacy [0.03%]
低分子量肝素-三乙醇胺软膏的开发与表征：透皮吸收及抗凝血功效研究
Masayori Hagimori,Seitaro Kamiya
Masayori Hagimori
Heparin's coagulation factor inhibitory activity varies depending on its molecular size. Low-molecular-weight heparin (LMWH), which has fewer side effects, such as bleeding, compared to unfractionated heparin, has attracted attention. To de...
Quality-by-design evaluation of Pickering emulsion-assisted spherical crystallization: A case study on ibuprofen [0.03%]
Pickering型乳液辅助的球晶制备工艺的质量源于设计研究——以布洛芬为例
Jianjian Xiao,Yifan Song,Zishi Chen et al.
Jianjian Xiao et al.
Spherical crystallization is a widely used particle design technique in pharmaceuticals, integrating crystallization, milling, and granulation into a single step to reduce production costs and improve quality control. Pickering emulsions, s...
Dry powder inhalation of siRNA therapeutics: Emerging strategies for pulmonary gene silencing [0.03%]
干粉吸入siRNA药物：肺部基因沉默的新兴策略
Yicheng Lu,Min Zhao,Meng Li et al.
Yicheng Lu et al.
Small interfering RNA (siRNA) holds great promise for treating pulmonary diseases by enabling targeted gene silencing. However, effective delivery of siRNA to the lungs faces multiple challenges, including enzymatic degradation, mucus clear...
Premlata Kuldip Ambre,Steven Baertschi,Jared S Bee et al.
Premlata Kuldip Ambre et al.
Kenneth L Audus
Kenneth L Audus
What happens after you apply it to the skin? Evaporative metamorphosis and the transformation of critical quality attributes in topical products [0.03%]
外用后发生了什么？皮肤蒸发形变及局部产品质量关键属性的转变
S Narasimha Murthy
S Narasimha Murthy
Topical dermatological formulations undergo profound compositional, physicochemical, and microstructural transformations upon application to the skin. This process, termed evaporative metamorphosis, alters critical quality attributes (CQAs)...