Reformulating Rofecoxib: Targeted Nanostructured Lipid Carrier Gel for Localized Treatment of Rheumatoid Arthritis [0.03%]
罗非昔布改良型药物传递系统：用于局部治疗类风湿性关节炎的纳米结构脂质载体凝胶制剂
Sanket Gangurde,Abhijeet A Aher,Nayan A Gujarathi et al.
Sanket Gangurde et al.
Objective: This study aimed to develop and evaluate nanostructured lipid carrier (NLC) gel loaded with rofecoxib (ROX) for topical treatment of rheumatoid arthritis (RA), minimizing systemic exposure and cardiotoxicity.Significance: Despite...
Novel stable micellar formulation for ocular delivery of nepafenac: optimization, characterization and in-vitro evaluation [0.03%]
优化、表征和体外评价的新稳定的那匹酚酰胺眼用micellar制剂
Ronak Vashi,Kishorkumar Sorathia
Ronak Vashi
Objective: The objective of this study was to develop a stable clear ophthalmic nano-micellar formulation of Nepafenac.Significance:The current marketed suspension formulation of nepafenac indicated for post-surgical uvei...
Dermal Gel Formulation of Guiera Senegalensis (Sabara) Leaf Extract: Development, Characterisation, and Antibacterial Evaluation [0.03%]
塞内加尔革参叶提取物的皮肤凝胶制剂：开发、表征及抗菌评价
Nafiu Aminu,Abdulrahman Haliru Sidi,Zainab Attahiru et al.
Nafiu Aminu et al.
Objective: This study aimed to develop and evaluate a dermal gel formulation incorporating the methanolic leaf extract of Guiera senegalensis (GS) for potential topical antimicrobial application.Significance:Dermal gel fo...
Integrated stability and metabolomic investigation of new rifampicin and isoniazid co-loaded liposome against tuberculosis [0.03%]
新型利福平和异烟肼共载脂质体抗结核的稳定性及代谢组学研究
Pragati Sinha,Vinod L Gaikwad,Debabrata Mandal et al.
Pragati Sinha et al.
Objectives: This study aimed to develop and evaluate rifampicin (RIF) and isoniazid (INH) co-loaded liposome for sustained drug delivery to enhance therapeutic efficacy against tuberculosis (TB) and overcome challenges as...
Ultrasound-assisted green extraction of antioxidant and antimicrobial resins from Cannabis sativa for potential pharmaceutical applications [0.03%]
超声辅助绿色提取大麻抗氧化和抗菌树脂的潜在药物应用研究
Sofía Ivonne Ruiz Miraglio,Matías Alejandro Raspo,Nicolás Costamagna et al.
Sofía Ivonne Ruiz Miraglio et al.
Objective: To develop a green and efficient ultrasound-assisted extraction (UAE) process to obtain bioactive resins from Cannabis sativa with potential pharmaceutical applications, optimizing extraction parameters to maxi...
Construction of albumin based nanoparticles utilizing paclitaxel-fatty acid prodrug that mimicking the natural fatty-acid binding process in vivo to synergistically elevate ROS withβ-lapachone for cooperative cancer therapy [0.03%]
利用喜树碱衍生物协同增敏肿瘤内源性ROS生成的基于白蛋白的载药纳米粒抗肿瘤研究
Yanli Zhao,Yimu Li,Yan Chen et al.
Yanli Zhao et al.
Objective: The aim of this study was to develop a chemotherapy drug paclitaxel (PTX) and a tumor specific ROS generation agent β-lapachone(LAP) co-loaded human serum albumin (HSA) based nanoparticles (ANPs) for synergist...
Panaxadiol Saponins-Loaded Gel for Periodontitis Therapy: Anti-Inflammatory and Microbiota-Modulating Effects [0.03%]
用于牙周炎治疗的 panaxadiol 皂苷凝胶：抗炎和调节微生物群的作用
Xin Zeng,Hanling Shi,Ming Chen et al.
Xin Zeng et al.
Objective: To evaluate the anti-inflammatory activity and mechanism of Panaxadiol saponins (PDS), develop a PDS-based gel for periodontitis treatment, and evaluate its therapeutic efficacy using a rat model of periodontit...
An in vitro release test method with Immersion Cells for evaluation of drug release performance of butenafine hydrochloride cream [0.03%]
含布特南芬氯化物软膏的体外释放度试验方法的研究
Ping Li,Rongqin Zhang,Xin Li et al.
Ping Li et al.
Objective: To establish an in vitro release (IVR) method for butenafine hydrochloride cream using Immersion Cells and compare the drug release characteristics of commercial samples. ...
Current developments and future directions in androgen receptor targets using nano-based therapeutics for the management of cancer [0.03%]
基于纳米药物的雄激素受体靶点在癌症治疗中的最新进展和未来方向研究
Nirali Shukla,Anam Sami,Deepshikha Rathore et al.
Nirali Shukla et al.
Nanoformulated androgen receptor (AR) antagonists constitute a cutting-edge advancement in the treatment of AR-driven cancers by significantly enhancing the precision and effectiveness of therapy. These nanoparticle-based formulations are u...
Deoxycholic acid as a permeability enhancer of two antidiabetic drugs with distinctive biopharmaceutical properties through biological barriers [0.03%]
一种胆汁酸作为两种具有不同药剂学特性的抗糖尿病药物通过生理屏障的渗透增强剂的研究
Mladena N Lalic-Popovic,Velibor M Vasovic,Nemanja B Todorovic et al.
Mladena N Lalic-Popovic et al.
Introduction: In the early stages of drug development, evaluating physicochemical properties is crucial for anticipating a compound's absorption, distribution, and therapeutic efficacy. The distribution coefficient (logD)...