Design, Optimization, and Evaluation of Ferulic Acid-Loaded Cubosomal Cream for Enhanced Topical Delivery and Anti-Hyperpigmentation Efficacy [0.03%]
一种用于改善透皮给药和抗色素沉着有效性的白桦酯酸载药胶束状脂质体乳膏的设计、优化与评估
Rutuja Vinchurkar,Ashwin Kuchekar
Rutuja Vinchurkar
Objective: The goal of this study was to create and optimize a topical cream based on cubosomes for improved dermal delivery and stability of ferulic acid, a strong antioxidant with anti-hyperpigmentation properties that ...
Development of a transdermal sumatriptan formulation with iontophoresis [0.03%]
一种电穿孔经皮给药的苏马曲坦新剂型的研发工作
Kenji Mori,Takeshi Oshizaka,Kenji Sugibayashi
Kenji Mori
Objective: A transdermal iontophoretic formulation for sumatriptan was approved by the U.S. FDA in 2013 for patients who cannot take oral medications. However, it was withdrawn in 2020 due to skin burns and scarring assoc...
Leveraging Bile Acid Transporters for Enhanced Liver Targeting and Anti-alcoholic Efficacy of Tectoridin via Liposomal Delivery [0.03%]
利用脂质体递送调控胆酸转运体以增强地菍素抗酒精作用及其肝脏靶向性
Xia Cao,Yaping Yang,Michael Adu-Frimpong et al.
Xia Cao et al.
Objective: This study focused on improving the delivery of tectoridin, an anti-alcoholic compound from Pueraria flower, which suffers from poor solubility and low bioavailability when taken orally. To address this, we des...
Medium-Chain Fatty Acid-Enabled Nanostructured Lipid Carriers for Improved β-carotene Biopharmaceutical Properties and Antioxidant Efficacy [0.03%]
中链脂肪酸介导的结构脂质载体用于改善β-胡萝卜素的药代动力学性质及抗氧化效果
Wan-Yi Liu,Ting-Wen Fu,Horng-Huey Ko et al.
Wan-Yi Liu et al.
ObjectiveThis study aimed to enhance the in vitro digestion and permeability of β-carotene (BC), a lipophilic antioxidant with therapeutic potential in oxidative stress-related disorders, by developing a nanostructured lipid carrier (NLC) ...
Carbon nanotubes as gene delivery vectors: Navigating endosomal escape and intracellular fate [0.03%]
用于基因传递的碳纳米管：穿越内体逃逸和胞内命运之旅
Hichem Bensaada,Evgeny A Turetskiy,Kiryowa Idrisa
Hichem Bensaada
Objective: Carbon nanotubes (CNTs) have emerged as non-viral gene delivery vectors, due to their physicochemical properties, high surface area, anisotropic needle-like geometry, tunable surface chemistry, and unique optic...
Analytical Quality by Design (AQbD)-Based RP-HPLC Method Development and Validation for Concurrent Determination of Meloxicam and Chlorhexidine in a Novel Dental In-Situ Gel for Odontalgia [0.03%]
基于分析性质量设计(AQbD)的RP-HPLC方法开发与验证同时测定用于牙痛的新型口腔原位凝胶中美洛昔康和氯己定的方法
Shiv Kumar,Nitasha Chauhan,Shruti Chopra et al.
Shiv Kumar et al.
Objective: Odontalgia (Tooth pain) involves inflammation and infection, requiring anti-inflammatory and antibacterial agents to manage pain. Conventional gels containing NSAIDs, topical anesthetics, and antibacterial agen...
Smart Drug Delivery Systems Based on Frictional Stimulus-Responsive Mechanisms: Principles and Applications [0.03%]
基于摩擦刺激响应机制的智能药物递送系统：原理及应用
Mei Lv,Qianqian Sun,Guofa Zhang et al.
Mei Lv et al.
Objective: This review systematically summarizes the mechanisms and applications of friction as both endogenous and exogenous stimuli in drug delivery systems. ...
Naringenin-Loaded Niosomal Vaginal In Situ Gel: Preclinical Study in Polycystic Ovary Syndrome-Induced Female Wistar Rats [0.03%]
载narigenin硝唑阴道就地凝胶的药代动力学和生物效应：在多囊卵巢综合症诱导的wistar大鼠模型中的临床前研究
Anvitha Welda Sequeira,Kishori P Sutar,Prakash R Biradar et al.
Anvitha Welda Sequeira et al.
Aim: This study aims to develop and assess Naringenin-loaded niosomal vaginal in situ gel for the effective management of Polycystic Ovary Syndrome. The objectives include enhancing drug permeation, ensuring sustained rel...
Development and characterization of olopatadine and verbascoside-loaded thermoresponsive in situ gels for ocular drug delivery: a factorial design approach for allergic conjunctivitis [0.03%]
用于治疗过敏性结膜炎的奥洛帕丁和鼠李皮素温敏原位凝胶的眼用制剂的开发及表征：一种析因设计方法
Heybet Kerem Polat,Tuğba Çopur,Esra Pezik et al.
Heybet Kerem Polat et al.
Objective: Allergic conjunctivitis is one of the most prevalent conditions affecting the eyes, and various medications are used in its treatment. In this study, olopatadine and verbascoside were used in combination. ...
Formulation and optimization of venlafaxine loaded nanostructure lipid carrier based intranasal drug delivery system for brain targeting through in vivo study [0.03%]
基于体内研究的文拉法辛鼻用给药系统的纳米结构脂质载体递送体系的设计及优化
Sulekha Khute,Subash Paranthaman,Rajendra Kumar Jangde
Sulekha Khute
Objective: This study aimed to develop and optimize nanostructured lipid carriers (NLCs) to deliver venlafaxine (VLF) intranasally to optimize its brain bioavailability. ...