Optimization of Clausena anisata Leaf Extract Lozenges as Smoking Cessation Aid: Quality by Design Approach, Trial-Scale Production at Manufacturing Site, and Stability Evaluation [0.03%]
一种用于戒烟的Clausena anisata叶提取物含片的质量设计优化：制造现场中试生产及稳定性评价
Natawat Chankana,Poj Kulvanich,Jirapornchai Suksaeeree et al.
Natawat Chankana et al.
Objective: The objective of this study was to develop and optimize Clausena anisata leaf extract (CLE) lozenges, a smoking cessation aid, using a Quality by Design (QbD) approach. ...
Loise Silveira da Silva,Izabelle de Mello Gindri,Maria Johann Fensterseifer et al.
Loise Silveira da Silva et al.
Objective: To analyze drug's physicochemical properties and dissolution profiles of testosterone tablets compressed with two different load levels (2 and 15 tons) and to evaluate the influence of process additive on table...
Prediction of Penicillin Concentration Using Time Series Forecasting and Machine Learning Techniques [0.03%]
基于时间序列预测和机器学习技术的青霉素浓度估计模型
Michail Rekkas-Ventiris,Panorios Benardos
Michail Rekkas-Ventiris
Background: Time-series forecasting is crucial in pharmaceutical fermentation, where early detection of deviations safeguards product quality. As the industry evolves toward Pharma 4.0, integrating machine learning into p...
Development of nimesulide-loaded pH-triggered ocular in situ gels; In vitro characterization, MTT assay and Drazie test [0.03%]
尼美舒利载药pH触发型眼部原位凝胶的制备及其体外表征、MTT试验和Draize试验研究
Nasif Fatih Karakuyu,Heybet Kerem Polat,Sedat Unal et al.
Nasif Fatih Karakuyu et al.
Objective: The present study created nimesulide-loaded in situ gels and assessed their potential application in ocular inflammation. Methods: ...
Injection molded multidrug intravaginal rings with antimicrobial properties for prophylaxis and cancer treatment in women's health context [0.03%]
具有抗菌性能的用于女性健康的多药阴道环注射模制模具用于预防和癌症治疗
Gabriela Abreu Raimundo,Tauana Batistella,Maria Johann Fensterseifer et al.
Gabriela Abreu Raimundo et al.
OBJECTIVE: This study explores the development of intravaginal rings with controlled drug release, fabricated through injection molding, for the treatment of viral and bacterial gynecological diseases such as HIV/AIDS, cervical cancer cause...
Transdermal Delivery of Lornoxicam via Transethosomal Gel as a Novel Strategy for Management of Rheumatoid Arthritis [0.03%]
新型经皮给药策略：通过穿越脂质体凝胶递送洛硝考胺治疗类风湿性关节炎
Ayesha Muneer,Shefaat Ullah Shah,Rashna Mirza et al.
Ayesha Muneer et al.
Objective: This study aimed to develop and optimize lornoxicam-loaded transethosomal vesicles (LOR-TES) to improve the solubility, skin permeation, and transdermal delivery of lornoxicam for potential use in the treatment...
Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing [0.03%]
膳食和配制pH值调节对多种大鼠给药模型中BCS一至四类化合物药动学的影响
Satish Kumar,Lakshmi Prasanna Tattala,Ravi Akkireddy et al.
Satish Kumar et al.
Objective: This study was performed to appraise the effect of modulation of formulation pH and abdominal pH on the pharmacokinetics of the selected compounds from different drugs of the biopharmaceutics classification sys...
Formulation of metered-dose inhalers containing beclomethasone dipropionate using quality by design approach [0.03%]
基于质量设计的布地奈德混悬液定量吸入剂的开发
Tu Man Tieu,Van-Hoa Huynh,Thai-Duong Nguyen et al.
Tu Man Tieu et al.
Objective: Metered-dose inhalers (MDIs) containing corticosteroids are widely prescribed for the treatment of asthma and chronic obstructive pulmonary disease, but the high cost of brand-name products limits access in dev...
Stability, in vitro release, and pharmacokinetic evaluation of standardized crude extracts, isolated compounds, and their nano-liposomes derived from Syzygium campanulatum Korth using Sprague-Dawley rats [0.03%]
基于Syzygium campanulatum Korth的标准化粗提物、分离化合物及其纳米脂质体的大鼠稳定性、体外释放和药动学评价
Abdul Hakeem Memon,Osama Memon,Asad Ur Rahman et al.
Abdul Hakeem Memon et al.
Objective: This study aimed to leverage nano-liposomes (NLs) for optimizing the solubility, bioavailability, and pharmacokinetic profiles of 7-hydroxy-5-methoxy-6,8-dimethyl flavanone (7-HMDF), 5,7-dihydroxy-6,8-dimethyl-...
Folate-Functionalized Core-Shell Nanocarrier System for Sustained and Targeted Delivery of Saraca Indica for Breast Cancer Treatment [0.03%]
叶酸功能化核壳型纳米载体系统用于持续靶向递送密花豆提取物治疗乳腺癌
Youssra Ragheb,Sarah Yahia,Rabab M El Sherif et al.
Youssra Ragheb et al.
Background: Targeted therapy plays a crucial role in minimizing the adverse effects of chemotherapy on normal cells by specifically directing therapeutics to cancerous tissues. ...