Multi-Compartment Pharmacokinetics and Tissue Bioavailability of Coenzyme Q10 from a Phospholipid-Based Self-Nanoemulsifying Drug Delivery System in Rats: A Distribution Pattern Consistent with a Possible Lymphatic Contribution [0.03%]
基于磷脂的自纳米乳化药物递送系统对辅酶Q10大鼠体内药代动力学及组织生物利用度的影响：可能具有淋巴途径贡献的分布模式
Krishnamurthy Narasimha Prasad,Chaithra Chandrashekar,Srinivasa Krishnappa et al.
Krishnamurthy Narasimha Prasad et al.
Objectives: To evaluate a proprietary phospholipid-based self-nanoemulsifying CoQ10 delivery system using an integrated multi-compartment framework encompassing plasma pharmacokinetics, erythrocyte uptake, tissue distribu...
Evaluation of Compatibility of Domperidone with Selected Excipients used in Preparation of Orally Disintegrating Tablets [0.03%]
多潘立酮与口崩片用辅料相容性评价
Hamad S Alyami,Amjad Khan,Shabnam Nazir et al.
Hamad S Alyami et al.
Objective: The present study aims systematic evaluation of potential drug excipient interactions and by using a multi technique analytical approach. Signi...
Development and Evaluation of Rizatriptan Benzoate Orally Disintegrating Tablets for Migraine Treatment [0.03%]
利扎曲普坦苯甲酸盐口服速溶片的研发及评价用于偏头痛治疗
Nevin Çelebi,Emine Tuncay
Nevin Çelebi
ObjectiveThis study aimed to develop rizatriptan benzoate (RZT) orally disintegrating tablets (ODTs), used in migraine treatment, using various excipients and, in particular, super-disintegrants, through the direct compression method, and t...
Chemical Aspects of Controlled Cisplatin Release and Apoptosis via Nerium oleander Latex Nano-carriers in Breast Cancer Cells [0.03%]
利用夹竹桃乳胶纳米载体控制顺铂的释放及其在乳腺癌细胞中诱导凋亡的化学作用机制研究
Sultan Saad Almadhhi,Raju Suresh Kumar,D V Surya Prakash et al.
Sultan Saad Almadhhi et al.
Plant-derived nano-carriers offer a sustainable and targeted strategy for cancer therapy. This study reports the synthesis and characterization of a latex-hybrid nano-carrier derived from Nerium oleander (LHNC), engineered for cisplatin (CD...
Safety, Tolerability, and Pharmacokinetics of Oral FM888 in Healthy Chinese Adults: A Phase I, Randomized, Double-Blind, Placebo-Controlled Study [0.03%]
FM888口服溶液剂在健康中国成年人受试者中的安全性和耐受性以及药代动力学：一项I期随机双盲安慰剂对照研究
Yan Jiang,Fang Tian,Jianren Zhou et al.
Yan Jiang et al.
Purpose: Targeting adenylate cyclase 1 (AC1) offers a novel, non-opioid strategy for pain treatment. The active moiety of FM888 had been evaluated previously in an older tablet formulation. This Phase I study assessed the...
Comparative Evaluation of Nanofiber and Wafer-Based Systems for Ophthalmic Delivery of a Water-Soluble Drug [0.03%]
纳米纤维和晶片系统递送水溶性眼用药物的比较研究
Fatemeh Tavakoli,Mahya Farazmand,Marzieh Akrami et al.
Fatemeh Tavakoli et al.
Objective: Aimed at developing and comparing wafer and nanofibers as biocompatible and prolong release ophthalmic delivery systems, we have prepared various formulations of sulfacetamide-a soluble drug- and evaluate them....
Tumor microenvironment improved by nanostructured lipid carriers co-deliverying paclitaxel and ubenimex to treat breast cancer [0.03%]
载有紫杉醇和乌苯美司的纳米结构脂质载体联合递药改善乳腺肿瘤微环境用于治疗乳腺癌
Shuai Xia,Tao Sheng,Jia-Min Li et al.
Shuai Xia et al.
Objective: The aim of this research was to design nanostructured lipid carriers co-delivering paclitaxel and ubenimex to improve the tumor microenvironment and enhance efficacy against breast cancer. ...
Advances in Pectin-Based Bead Formation via Ionotropic Gelation for Enhanced Drug Delivery: A Scoping Review [0.03%]
基于离子交联的果胶基微球制备及其在药物递送中的应用进展：范围研究型文献综述
Laura Helena Schroeder Borges,Victoria Louise de Luca,Joslaine Jacumazo et al.
Laura Helena Schroeder Borges et al.
Objective: This review summarizes recent advances in pectin-based beads produced via ionotropic gelation for drug delivery, focusing on formulation variables, processing parameters, and their influence on encapsulation ef...
Hamed Morad,Reza Abdollahzadeh,Mostafa Rostamnezhad et al.
Hamed Morad et al.
Objective: To review the design strategies and therapeutic applications of transformable nanosystems in cancer therapy. Significance of review: ...
Harnessing the potential of spider silk proteins as emerging biomaterials for drug delivery: classification, comparative evaluation and future perspectives [0.03%]
蛛丝蛋白作为药物递送生物材料的潜力：分类、比较评估和未来展望
Jahanvi Kumari,Shruti Chopra,Sanjay Bharati et al.
Jahanvi Kumari et al.
ObjectiveThe objective of this review is to consolidate the role of native and recombinant spider silk in drug delivery systems. It aims to classify and compare their performance with natural and synthetic polymers, and emphasises their pot...