Design and self-assembly of nanomicelles loading 5-fluorouracil-ferulic acid cocrystal with synergistic antitumor activity: towards efficient encapsulation and sustained-release effect [0.03%]
一种高效包载和长效释药的负载5-氟尿嘧啶-阿魏酸共晶的纳米胶束的设计及自组装：协同抗肿瘤作用研究
Yue-Ming Yu,Xue-Jie Li,Zhi-Long Zhao et al.
Yue-Ming Yu et al.
Objective: The research is aimed at fulfilling long-term and high-performance synergistic anticancer effects of 5-fluorouracil (Flu), opening up new horizons for drug-nutrient cocrystal formulation. ...
Advanced Nanoparticle-Enabled Risperidone Delivery for Improved Therapeutic Outcomes of Schizophrenia Management: A Review [0.03%]
用于改善精神分裂症管理治疗效果的新型利培酮递送系统：综述
Ashwin Kumar,Mahesha Keerikkadu,Pragathi Devanand Bangera et al.
Ashwin Kumar et al.
ObjectiveThis review aims to evaluate the therapeutic potential of Risperidone (RSP)-loaded nanoparticles as an innovative drug delivery approach for effective schizophrenia (SZ) management and improved patient outcomes.SignificanceSchizoph...
Dual Extrusion-based 3D-Printed Core-Shell Tablets for Colorectal Delivery of Mebeverine Hydrochloride [0.03%]
基于双喷嘴3D打印的壳核片剂用于甲氧氯普胺的结肠给药
Azin Goudarzi,Tahmineh Karami,Hussein Abdelamir Mohammad et al.
Azin Goudarzi et al.
Objective: This study aimed to fabricate a delayed-release tablet of Mebeverine hydrochloride using a novel dual extrusion-based 3D printing approach to improve the management of irritable bowel syndrome (IBS). ...
Applications of Hot-Melt Extrusion in Drug Solubility Enhancement: Recent Innovations and Future Directions [0.03%]
热熔挤出在提高药物溶解度方面的应用：近期创新及未来方向
Shamama Javed
Shamama Javed
Objective: Hot-melt extrusion (HME) has emerged as a solvent-free, scalable, efficient, and continuous process to overcome the challenges of poor solubility in new drug entities. Using HME technique, crystalline drugs are...
Tartaric acid pellets as a core for extended-release of sildenafil citrate: development via solid dispersion and factorial design [0.03%]
棓酸颗粒作为西地那非的缓释核心：固体分散与析因设计开发
Amanda Moscibroski da Silva Bedin,Jéssika Adriane Janning,Volnei José Tondo et al.
Amanda Moscibroski da Silva Bedin et al.
Introduction: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by elevated pulmonary arterial pressure, causing vascular remodeling and eventual right heart failure. Sildenafil citrate (SC), a...
Sustainable Vesicular Nanosystems Incorporated Into Film-Forming Gels for Niacinamide Cutaneous Delivery [0.03%]
用于开发皮肤氨苯酚的可持续囊泡纳米系统薄膜形成凝胶中的纳入技术
Schauana Freitas Fraga,Larissa Pedron Duarte,Renata Vidor Contri et al.
Schauana Freitas Fraga et al.
Background: Niacinamide is a hydrophilic cosmetic ingredient whose low skin permeation and limited incorporation into conventional nanocarriers present significant challenges. ...
Development and characterization of injection molded multi drug delivery IUD for women's health therapy against bacterial and viral infections [0.03%]
一种女性健康治疗用抗菌抗病毒多药递送宫内节育器的研发与表征
Maycon Jair Coelho,Gustavo Ferrari,Loise Silveira da Silva et al.
Maycon Jair Coelho et al.
Objective: To develop and evaluate a scalable, multidrug-releasing intrauterine device (IUD) capable of treating common gynecological infections caused by viral, bacterial, and fungal pathogens. ...
Cathepsin C: A Critical Mediator Between Immune Response and Cardiovascular Disease - Therapeutic Implications of Enzyme Inhibition [0.03%]
猫hepsin C：免疫反应和心血管疾病之间的关键介质-酶抑制的治疗意义
Alaa A A Aljabali,Mohammad Obeid,Omar Gammoh et al.
Alaa A A Aljabali et al.
Cathepsin C (CatC) is a lysosomal dipeptidyl peptidase that performs multiple physiological and pathological functions in the body. This review focuses on the complex biological roles of this enzyme in proteolytic networks, immune cell regu...
Formulation and optimization of micro-emulgel loaded with Teucrium polium and chicken bile extracts [0.03%]
载有特克里乌姆和鸡胆提取物微乳凝胶的处方及优化研究
Fatima Zohra Badaoui,Abdallah Bakhouche,Soheib Bechkri et al.
Fatima Zohra Badaoui et al.
Objective: In order to optimize the extraction of Teucrium polium (TP) and chicken bile (Bi), evaluate their biological activities and formulate a micro-emulgel for hemorrhoidal therapy. ...
Nanocarriers as Drug Delivery System for Chemotherapeutic Agents: from Inception to Clinical Implementation [0.03%]
化疗药物的纳米载体给药系统：从概念到临床实施
Talha Zubair,Sheikh Arefin Rashid,Nishat Laila Bristy et al.
Talha Zubair et al.
Objective: This review investigates the advancements of nanocarrier-based chemotherapeutic agents from their inception to present-day implementation. It focuses on the types of nanocarriers introduced to date, the FDA-app...