Microfluidic-Based Intra-Articular Sustained Release of Triamcinolone Acetonide Microsphere-Gel Composite System [0.03%]
基于微流控技术的透明质酸凝胶载Ace联合玻璃体腔注射治疗新生血管性年龄相关黄斑变性的临床疗效观察
Yuan Zhu,Yongqi Lv,Jiaqi Xu et al.
Yuan Zhu et al.
Objective: This study presents a novel injectable microsphere-gel system for sustained intra-articular delivery of triamcinolone acetonide (TA) to treat osteoarthritis. ...
Quality by Design in parenteral drug development: Addressing formulation challenges and industrial insights [0.03%]
基于质量的设计在注射剂开发中的应用：配方挑战及工业实践启示
Kanika Thakur,Simran Deep Kaur,Ditsaah Kak et al.
Kanika Thakur et al.
Objective: The primary aim of the study is to highlight the application of Quality by Design (QbD) in the formulation of parenterals, with a focus on academic and industrial aspects. ...
Pre-formulation studies and orodispersible formulation of solidagenone, a labdane diterpene from Solidago chilensis Meyen, with potential anti-asthmatic activity [0.03%]
南美雏菊中抗哮喘活性成分固醇胶诺烯的药物开发前研究及或可分散固体剂型的制定
Deise Cristina Drummond Xavier Paes Lopes,Isadora Guimarães da Silva,Ana Beatriz Souza Soares et al.
Deise Cristina Drummond Xavier Paes Lopes et al.
Objective: This study aimed to develop and characterize orodispersible tablets (ODTs) containing solidagenone (SLG), a bioactive constituent of Solidago chilensis Meyen with described anti-inflammatory properties and pote...
Atchaya C,Jawahar N,Roshan P Rao et al.
Atchaya C et al.
Objective: Rosuvastatin has been used to treat hyperlipidaemia commercially by reducing triglycerides, apolipoproteins, and low-density lipoproteins, increasing high-density lipoproteins, and decreasing triglycerides. ...
Kinetic and Biocatalytic Evaluation of Dodecyl Nicotinate Hydrolysis in Aqueous Buffers and Biological Media [0.03%]
月桂尼古酸酯在水缓冲液和生物介质中水解的动力学及生化催化性能评估研究
Razan Haddad,Bashar Al-Taani,Aliaa Al-Tarakji et al.
Razan Haddad et al.
Objective: This study evaluated the hydrolytic behavior of dodecyl nicotinate under chemical and biological conditions to determine its suitability as a controlled-release prodrug of niacin.Significance: Niacin therapy is...
"Enhancing Intranasal Transport: Levetiracetam-Loaded Nanospheres Journey from Nose to Brain-Optimization via Box-Behnken Design and Comprehensive In vitro/In vivo Assessment" [0.03%]
“鼻用药物传输增强：利维坦素酯纳米球从鼻至脑传输之旅——基于Box-Behnken设计的优化及全面体内外评估”
Zeinab M Hussein,Afaf A Ramadan,Shereen A Eladawy et al.
Zeinab M Hussein et al.
Objective: The aim of this work was to formulate and develop LEV loaded nanospheres in situ nasal gel. Significance: This is an efficie...
Novel Elastic Nanovesicular Hydrogel System: Advancing Metronidazole Delivery for Effective Periodontitis Management [0.03%]
新型弹性纳米囊凝胶系统：提高甲硝唑的递送以有效管理牙周炎
Arooj Komal,Naveed Ahmed,Muhammad Usman Khan et al.
Arooj Komal et al.
ObjectivePeriodontitis, characterized by chronic gingival inflammation driven by polymicrobial biofilm formation, presents a significant therapeutic challenge due to the inherent difficulty of antimicrobial penetration through the biofilm m...
Formulation and evaluation of an enoxaparin aqueous spray for the treatment of contusions by topical application [0.03%]
用于治疗外伤性淤血的达肝素钠喷雾剂的处方与评价
Neha Singh,Sree Prakash Pandey,Shweta Yadav et al.
Neha Singh et al.
Objectives: Enoxaparin (ENX), an anticoagulant, was developed as a topical aqueous spray that provides rapid treatment for contusions by dissolving micro-clots, reducing inflammation, and thereby alleviating pain and edem...
Statistically Optimized Liposomal Formulation of Dorzolamide Hydrochloride for Sustained Ocular Delivery: In vitro and Allergic Evaluation in Rabbit [0.03%]
一种用于持续眼部给药的 dorzolamide 羟氯化物脂质体制剂的统计优化配方：兔体内的体外和过敏评价
Susanta Paul,Anannya Bose,Kunal Ray et al.
Susanta Paul et al.
SignificanceThe liposomal formulation reveals a safe, sustained, and efficient ocular drug delivery to improve the therapeutic potential of dorozolamide hydrochloride in glaucoma treatment.ObjectiveA liposomal formulation of Dorzolamide hyd...
Role of novel drug delivery system in enhancing iron bioavailability and reducing gastrointestinal side effects in iron deficiency anemia [0.03%]
新型给药系统在提高缺铁性贫血中铁的生物利用度和减少胃肠副作用方面的角色
Bindu Soni,Riya Shivgotra,Kamal Kishore Kashyap et al.
Bindu Soni et al.
ObjectiveThe primary objective of this review is to comprehensively analyse advancements in novel drug delivery systems, including carrier-based approaches, M cell targeting, and controlled and sustained release formulations, which have bee...