Development of nimesulide-loaded pH-triggered ocular in situ gels; In vitro characterization, MTT assay and Drazie test [0.03%]
尼美舒利载药pH触发型眼部原位凝胶的制备及其体外表征、MTT试验和Draize试验研究
Nasif Fatih Karakuyu,Heybet Kerem Polat,Sedat Unal et al.
Nasif Fatih Karakuyu et al.
Objective: The present study created nimesulide-loaded in situ gels and assessed their potential application in ocular inflammation. Methods: ...
Injection molded multidrug intravaginal rings with antimicrobial properties for prophylaxis and cancer treatment in women's health context [0.03%]
具有抗菌性能的用于女性健康的多药阴道环注射模制模具用于预防和癌症治疗
Gabriela Abreu Raimundo,Tauana Batistella,Maria Johann Fensterseifer et al.
Gabriela Abreu Raimundo et al.
OBJECTIVE: This study explores the development of intravaginal rings with controlled drug release, fabricated through injection molding, for the treatment of viral and bacterial gynecological diseases such as HIV/AIDS, cervical cancer cause...
Transdermal Delivery of Lornoxicam via Transethosomal Gel as a Novel Strategy for Management of Rheumatoid Arthritis [0.03%]
新型经皮给药策略：通过穿越脂质体凝胶递送洛硝考胺治疗类风湿性关节炎
Ayesha Muneer,Shefaat Ullah Shah,Rashna Mirza et al.
Ayesha Muneer et al.
Objective: This study aimed to develop and optimize lornoxicam-loaded transethosomal vesicles (LOR-TES) to improve the solubility, skin permeation, and transdermal delivery of lornoxicam for potential use in the treatment...
Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing [0.03%]
膳食和配制pH值调节对多种大鼠给药模型中BCS一至四类化合物药动学的影响
Satish Kumar,Lakshmi Prasanna Tattala,Ravi Akkireddy et al.
Satish Kumar et al.
Objective: This study was performed to appraise the effect of modulation of formulation pH and abdominal pH on the pharmacokinetics of the selected compounds from different drugs of the biopharmaceutics classification sys...
Formulation of metered-dose inhalers containing beclomethasone dipropionate using quality by design approach [0.03%]
基于质量设计的布地奈德混悬液定量吸入剂的开发
Tu Man Tieu,Van-Hoa Huynh,Thai-Duong Nguyen et al.
Tu Man Tieu et al.
Objective: Metered-dose inhalers (MDIs) containing corticosteroids are widely prescribed for the treatment of asthma and chronic obstructive pulmonary disease, but the high cost of brand-name products limits access in dev...
Stability, in vitro release, and pharmacokinetic evaluation of standardized crude extracts, isolated compounds, and their nano-liposomes derived from Syzygium campanulatum Korth using Sprague-Dawley rats [0.03%]
基于Syzygium campanulatum Korth的标准化粗提物、分离化合物及其纳米脂质体的大鼠稳定性、体外释放和药动学评价
Abdul Hakeem Memon,Osama Memon,Asad Ur Rahman et al.
Abdul Hakeem Memon et al.
Objective: This study aimed to leverage nano-liposomes (NLs) for optimizing the solubility, bioavailability, and pharmacokinetic profiles of 7-hydroxy-5-methoxy-6,8-dimethyl flavanone (7-HMDF), 5,7-dihydroxy-6,8-dimethyl-...
Folate-Functionalized Core-Shell Nanocarrier System for Sustained and Targeted Delivery of Saraca Indica for Breast Cancer Treatment [0.03%]
叶酸功能化核壳型纳米载体系统用于持续靶向递送密花豆提取物治疗乳腺癌
Youssra Ragheb,Sarah Yahia,Rabab M El Sherif et al.
Youssra Ragheb et al.
Background: Targeted therapy plays a crucial role in minimizing the adverse effects of chemotherapy on normal cells by specifically directing therapeutics to cancerous tissues. ...
Ultra-Stabilized Transethosomal Gel for Co-Delivery of 5-Fluorouracil and Carvedilol: Cytotoxicity and In-vivo studies in Skin Cancer [0.03%]
用于联合递送5-氟尿嘧啶和卡维地洛的超稳定跨脂质体凝胶：癌皮肤的细胞毒性和体内研究
Prafull Shinde,Amit Page
Prafull Shinde
ObjectiveSkin cancer is a widespread malignancy requiring advanced strategies to address poor skin permeation, drug resistance and low local bioavailability. This study aimed to develop and evaluate FU-CVD-loaded transethosomal gel for enha...
Quality by Design-Driven Approach to Develop a Nanocarrier-Based Sulfasalazine Topical System for Rheumatoid Arthritis Management [0.03%]
基于质量设计的载磺胺吡唑钠纳米载体外用制剂的研发用于类风湿性关节炎的治疗
Ankit Raj,Pradip Nirbhavane,Himanshu Gandhi et al.
Ankit Raj et al.
ObjectiveThis study was conducted to improve the transdermal delivery of Sulfasalazine, by encapsulating it into the nanostructured lipid carrier (NLC)-based gel products.MethodsSulfasalazine (SSZ) was loaded into NLCs through solvent diffu...
A Framework for Transferring Sinomenine Hydrochloride Sustained-Release Tablet from Batch to Continuous Direct Compression Manufacturing [0.03%]
氯化丝瓜碱缓释片从批次生产向连续直接压片生产的转换框架研究
Guoming Zhou,Hao Chang,Guangpu Fang et al.
Guoming Zhou et al.
Objective The primary objective of this study was to establish and validate a practical framework for the transfer of a Sinomenine Hydrochloride sustained-release tablet from a legacy batch process to a pilot-scale Continuous Direct Compres...