Degradation kinetics of apomorphine hydrochloride in buffered formulations and the effect of antioxidants [0.03%]
缓冲体系中盐酸阿朴吗啡降解动力学及抗氧剂的影响研究
Abeer M Al-Ghananeem,Sarah Baltzley,Azzam A Malkawi et al.
Abeer M Al-Ghananeem et al.
Introduction: Apomorphine (APO) is inherently unstable in aqueous solutions, as it forms auto-oxidation products. The study investigates the degradation kinetics of APO as the function of pH and evaluates the stabilizing ...
Development of berberine-loaded PEGylated liposomes: in-vitro and ex-vivo evaluation [0.03%]
载小檗碱PEG修饰脂质体的制备及其体内外评价研究
Neeraj Kumar,Akanksha,Rama Tyagi et al.
Neeraj Kumar et al.
Objective: To develop and evaluate a PEGylated berberine (BE)-loaded nanoliposome formulation (Opt-BE-PEG-Ls) using a Quality by Design (QbD) approach, aimed at providing an effective, long-term antidiabetic therapeutic s...
Polysaccharide-based suspensions: A novel pediatric-friendly formulation for administering furosemide through nasogastric tubes [0.03%]
基于多糖的悬浮液：通过鼻胃管为儿童给药呋塞米的一种新型儿童友好型配方
Luiza Gonçalves Soutier,Carla Suellen Gurski,Felipe Neme Ribeiro et al.
Luiza Gonçalves Soutier et al.
Objective: Our study aimed to develop extemporaneous furosemide suspensions using a polysaccharide as the suspensor agent and to evaluate their stability and drug loss during tube administration. ...
Preparation, characterization of geraniol/HP-β-CD inclusion complex and its acute toxicity evaluation in mice [0.03%]
牻牛儿醇/羟丙基倍他环糊精包合物的制备、表征及其急性毒性评价
ZhongHui Pu,SiYi Luo,XingYun Liao et al.
ZhongHui Pu et al.
Objective: This study prepared a geraniol (Ger)/hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex (IC) and evaluated its acute toxicity in mice to support applications in functional foods and pharmaceuticals.. ...
Cabotegravir-loaded polymeric micelles: a promising strategy for improved solubility and therapeutic outcomes [0.03%]
卡博特egravir载药聚合物胶束：提高溶解性和治疗效果的策略
Siddharth Vernekar,Archana S Patil,Yadishma A Gaude et al.
Siddharth Vernekar et al.
Objective: To design and optimize a d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-stabilized polymeric micellar system for cabotegravir (CAB), strategically addressing its dissolution-rate and permeability con...
Lipid-polymer conjugated Nanocarriers of Ferulic Acid for Obesity Intervention via Oxidative Stress Regulation [0.03%]
通过调节氧化应激作用的富马酸脂质聚合物纳米载体用于肥胖干预
Preeti Meshram,Suvarna Bhadane,Dipika Pakhare et al.
Preeti Meshram et al.
Objective: Ferulic acid (FA) exhibits antioxidant and metabolic regulatory properties; however, its clinical translation in obesity management is limited by poor aqueous solubility, low permeability, and rapid systemic cl...
An innovative RP-HPLC strategy for dual-drug analysis: simultaneous estimation of selegiline and biochanin A in bulk and SNEDDS [0.03%]
一种创新的RP-HPLC策略用于两种药物的同时分析：同时估算盐酸司来吉兰和Biochanin A在原料药和SNEDDS中的含量
Shivani Tyagi,Manisha Trivedi,Jayendra Kumar
Shivani Tyagi
Introduction: This study aimed to develop and validate a rapid, accurate, and robust RP-HPLC method for the simultaneous quantification of Selegiline (SEL) and Biochanin A (BCA) in bulk and in self-nanoemulsifying drug de...
Optimization of Clausena anisata Leaf Extract Lozenges as Smoking Cessation Aid: Quality by Design Approach, Trial-Scale Production at Manufacturing Site, and Stability Evaluation [0.03%]
一种用于戒烟的Clausena anisata叶提取物含片的质量设计优化：制造现场中试生产及稳定性评价
Natawat Chankana,Poj Kulvanich,Jirapornchai Suksaeeree et al.
Natawat Chankana et al.
Objective: The objective of this study was to develop and optimize Clausena anisata leaf extract (CLE) lozenges, a smoking cessation aid, using a Quality by Design (QbD) approach. ...
Loise Silveira da Silva,Izabelle de Mello Gindri,Maria Johann Fensterseifer et al.
Loise Silveira da Silva et al.
Objective: To analyze drug's physicochemical properties and dissolution profiles of testosterone tablets compressed with two different load levels (2 and 15 tons) and to evaluate the influence of process additive on table...
Prediction of Penicillin Concentration Using Time Series Forecasting and Machine Learning Techniques [0.03%]
基于时间序列预测和机器学习技术的青霉素浓度估计模型
Michail Rekkas-Ventiris,Panorios Benardos
Michail Rekkas-Ventiris
Background: Time-series forecasting is crucial in pharmaceutical fermentation, where early detection of deviations safeguards product quality. As the industry evolves toward Pharma 4.0, integrating machine learning into p...