Injectable grafts for hard tissue engineering: current trends and future perspectives [0.03%]
用于硬组织工程的注射型移植物：现状和未来展望
Rajeev Ranjan,Vikash Kumar,Ayush Katyayan
Rajeev Ranjan
Objective: Injectable bone grafts have emerged as a promising solution for bone tissue regeneration due to their minimally invasive nature and ability to conform to complex anatomical defects. Recent advancements in mater...
Intranasal Nanoemulsion-based In-Situ Gel Containing Dexlansoprazole: Formulation Development, In-Vitro and Ex-Vivo Evaluation [0.03%]
含有DEXLANSOPRAZOLE的鼻用纳米乳原位凝胶制剂的研发及体外和在体评价
Gyati Shilakari,U Sai Kumar,Meghamala G et al.
Gyati Shilakari et al.
Aim: Dexlansoprazole (DXL) is clinically effective in gastroesophageal reflux and ulcer healing, yet its oral bioavailability is compromised by acid instability, poor aqueous solubility, and extensive first-pass metabolis...
Estimation of rezdiffra (MGL-3196) by validated RP-HPLC approach in bulk material and pharmaceutical formulation [0.03%]
一种经验证的RP-HPLC方法在原料和制剂中估算Rezdiffra（MGL-3196）含量
Md Abid Hasan,Raisa Tasnim,Ejaj Sumit et al.
Md Abid Hasan et al.
Introduction: Rezdiffra MGL-3196 is a newly authorized systemic medication for moderate to severe liver fibrosis associated with noncirrhotic nonalcoholic steatohepatitis (NASH). ...
Curcumin-loaded beta-glucan nanoparticles: preparation, physicochemical properties, and molecular modeling [0.03%]
姜黄素载荷β-葡聚糖纳米粒：制备、理化性质及分子模拟研究
Quoc-Hoai Nguyen,An-Khanh Pham,Huu-Manh Nguyen et al.
Quoc-Hoai Nguyen et al.
Objectives: This study introduces the application of wet milling, a well-established top-down technique, as a novel approach for preparing beta-glucan nanoparticles (BG-NPs) as carriers for poorly soluble drugs, using cur...
Enhanced topical delivery of terbinafine HCl nanomicelles embedded in chitosan gel for improved antifungal activity [0.03%]
壳聚糖凝胶中特比萘芬HCl纳米胶束制剂的经皮递送及其抗真菌作用增强效果的研究
Gul-E Maryam,Fazli Nasir,Shazma Gohar et al.
Gul-E Maryam et al.
Objectives: Terbinafine Hydrochloride nanomicelles loaded chitosan gel was prepared with a goal to provide effective and controlled drug deliveryto the skin layers where conventional topical preparations are unable to pen...
AQbD-based UHPLC approach for quantification of everolimus residues in cleaning validation processes [0.03%]
基于AQbD的UHPLC法在抗肿瘤药物西罗莫司清洁验证过程残留量测定中的应用研究
Jagdish Gohel,Ajay Patel,Rajendra Kotadiya
Jagdish Gohel
Objective: This study aimed to develop and validate a robust reverse-phase ultra-performance liquid chromatography (UHPLC) method for the quantification of everolimus residues on pharmaceutical manufacturing equipment sur...
Generative artificial intelligence and large language models in pharmaceutical formulation and personalized pharmacy: a review of opportunities, technical constraints, and regulatory readiness [0.03%]
生成式人工智能和大型语言模型在药物制剂和个人化药房中的应用：机遇、技术限制及监管准备情况综述
Atharv Shinde,Hrushikesh Mhaismale,Pratik Pawar et al.
Atharv Shinde et al.
Objective: This article reviews the emerging applications of generative artificial intelligence (GenAI) and large language models (LLMs) in areas beyond early drug discovery, specifically focusing on drug formulation and ...
Unlocking bactericidal potential of coenzyme Q10 through an optimized oral nano-system formulation approach: in-vitro characterization and antimicrobial evaluation [0.03%]
一种优化的辅酶Q10口服纳米系统制剂的体外特征和抗菌评价：解锁杀菌潜力
Heba Abdel Hafeez Ismail,Doaa Ahmed El-Setouhy,Basant A Habib et al.
Heba Abdel Hafeez Ismail et al.
Objective: Multidrug-resistant bacterial infections demand innovative therapies. Drug repurposing offers a faster, safer alternative to traditional development. ...
Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting [0.03%]
响应刺激的介孔硅纳米粒子在脑肿瘤诊疗和药物靶向中的应用研究
Mainuddin,Deepak Tomar,Amulya Jindal et al.
Mainuddin et al.
Objective: Designing a delivery system to target a drug to brain tumors (BT) is a complex process. Drug delivery to BT presents a plethora of obstacles, such as poor bioavailability, drug targeting and its efficacy due to...
Albendazole-loaded chitosan nanoparticle conjugated with hyaluronic acid for the treatment of psoriasis [0.03%]
负载 albendazole 的壳聚糖纳米粒与透明质酸共轭制剂治疗银屑病
Shrikanth Nair,Prabha Singh
Shrikanth Nair
Objective: To design and develop hyaluronic acid (HA) conjugated Albendazole (ABZ) loaded chitosan nanoparticles (HA-ABZ-CSNP) loaded hydrogel for the treatment of psoriasis. ...