Recent advances in cationic material integration for enhanced antimicrobial formulations [0.03%]
用于改善抗菌配方的阳离子材料集成的最新进展
Sara Salatin,Shirin Ahmadi,Parvin Abedi Ghobadloo et al.
Sara Salatin et al.
Objective: To review recent advances in cationic antimicrobial systems - including surfactants, polymers, peptides, quaternary ammonium-based materials, and ionic-liquid-derived agents - and to summarize emerging strategi...
Solid Dispersions: A Review on Instability, Improvement Methods and Future Development Directions [0.03%]
固体分散体的研究现状及未来发展趋势展望
Wenjuan Wang,Yurong Lin,Sheng Wang et al.
Wenjuan Wang et al.
Objective: To systematically review the structural characteristics, release mechanisms, and stability challenges of solid dispersions (SDs), identifying key determinants of physical instability and summarizing emerging st...
Recent advancements and clinical translation of cinnamaldehyde derivatives in therapeutics [0.03%]
肉桂醛衍生物在治疗中的最新进展及临床转化
Shakir Ullah Shakir,Saeed Ahmad Khan,Majeed Ullah et al.
Shakir Ullah Shakir et al.
Objective: This review systematically evaluates why CA derivatives have failed to transition from bench to bedside despite superior preclinical performance. ...
Preclinical Evaluation of Asparagus stipularis in a Rat Model of Metabolic Syndrome and Development of Its Nanoencapsulated Form [0.03%]
天门冬属植物Asparagus stipularis防治代谢综合征的药理学评价及纳米载体制备研究
Khaoula Adouni,Olfa Zouaoui,Pedro Brandão et al.
Khaoula Adouni et al.
Context: Asparagus stipularis Forssk. decoction (ASD) has shown potential metabolic and antioxidant benefits, yet its effects on pancreatic dysfunction associated with metabolic syndrome remain insufficiently explored. ...
Pre-formulation Study of 3D-Printed Topical Film by Semisolid Extrusion Incorporated with Spray-dried Extract of Punica granatum Linn [0.03%]
石榴提取物喷雾干燥应用于药物3D打印的处方前研究
José Roberto da Costa Rodrigues,João Victor Rocha Bitú,Camylla Janiele Lucas Tenório et al.
José Roberto da Costa Rodrigues et al.
Objective: To develop semisolid extrusion (SSE) 3D-printed topical films containing spray-dried extract (SDE) of Punica granatum Linn. leaves and determine how formulation properties and infill architecture influence film...
Pharmacokinetic and dissolution profiling of tadalafil formulated with SNEDDS and β-cyclodextrin in fast-dissolving tablets [0.03%]
基于SNEDDS和β-环糊精的硝苯地平快速溶解片的溶出度及药动学研究
Cyril Jose,Sankalp Gharat,Afiya Baig et al.
Cyril Jose et al.
One of the main challenges in the oral administration of tadalafil is its low water solubility, which limits its bioavailability. The research aims for enhancement of solubility and bioavailability for tadalafil, through comparing effective...
Improving Paclitaxel Permeation and Anticancer Efficacy through Soluplus-based Solid Dispersion with Piperine [0.03%]
通过胡椒碱制备Soluplus为基础的固体分散体改善紫杉醇透膜及抗癌效力
Riyad F Alzhrani,Syed Sarim Imam,Sultan Alshehri et al.
Riyad F Alzhrani et al.
Objective: This study aimed to develop and optimize a Soluplus-based Paclitaxel-Piperine (PTX-PPN) solid dispersion to enhance PTX solubility, intestinal permeation and anticancer efficacy in metastatic breast cancer cell...
Emerging Trends and Future Directions in CO-AMORPHOUS Solid Dispersions for BCS Class II and IV Drugs [0.03%]
二类和四类BCS药物共无定形固态分散体的新趋势和未来方向
Himali Rohit,Jitendra Patel,Manisha Lalan
Himali Rohit
Objective: The objective of this review is to critically evaluate the potential of co-amorphous solid dispersions (CASDs) in improving the performance of poorly soluble active pharmaceutical ingredients (APIs). ...
Boosting oral bioavailability of icaritin and piperine: A co-amorphous approach with molecular insights and performance validation [0.03%]
增加icaritin和胡椒碱的口服生物利用度：分子见解和性能验证的共无定形方法
Xiaoxian Yao,Weidong Ye,Pingfu Huang et al.
Xiaoxian Yao et al.
Purpose: To overcome the poor aqueous solubility limitations of Icaritin (ICT) and Piperine (PIP), which restrict their therapeutic potential, by developing a co-amorphous drug delivery system. ...
Effect of formulation components on surface free energy of orodispersible films [0.03%]
组成成分对口腔速崩膜片表面自由能的影响
Motoki Inoue,Moyumi Odate,Toshiro Fukami
Motoki Inoue
Objective: Surface free energy was demonstrated to be a useful formulation-guiding parameter relevant to the surface wettability of orodispersible film substrates, while also providing insight into disintegration behavior...