Host-Guest Complexes of Cucurbituril with the neutral Guest Valrubicin: An Experimental and Computational Study [0.03%]
葫芦[7]脲与中性 guest 长春地辛的主客体复合物研究：实验和计算研究
Yara N Al-Shdifat,Yazan H Akkam,Abdel-Monem M Rawashdeh et al.
Yara N Al-Shdifat et al.
IntroductionValrubicin (VAL) is an N-trifluoroacetyl 14-valerate derivative of the anthracycline doxorubicin (DOX)and is known to have anti-tumor activity. Unfortunately, itis characterized by low solubility and instability in aqueous solut...
QbD assisted formulation, optimization and characterization of psoralen phytosome prepared through thin film hydration method [0.03%]
质量源于设计指导的补骨脂内生噬植体的制备、优化及评价
Kamini Kamini,Dinesh Puri
Kamini Kamini
ObjectiveTo enhance dermal delivery and therapeutic potential of psoralen from Psoralea corylifolia in psoriasis through phytosomal encapsulation.SignificancePsoriasis is a chronic inflammatory skin disorder affecting 2-4% of the Western po...
Polymeric Oral Fast Dissolving Films of Metformin: Fabrication, Optimization, In Vitro and In Vivo Evaluation [0.03%]
甲福明聚合物口服快速溶解薄膜的制备、优化及体内外评价
Malik Muhammad Imtiaz,Sheikh Abdur Rashid,Faiza Naseem et al.
Malik Muhammad Imtiaz et al.
Background: Metformin is gold standard for polycystic ovary syndrome (PCOS), but associated with gastrointestinal side effects, leading to poor patient adherence. Present oral fast-dissolving films (OFDFs) offer rapid dis...
Greenness Assessment and Stability-Indicating Hptlc Method for The Concurrent Analysis of Empagliflozin and Metoprolol Succinate in A Novel Combined Oral Formulation [0.03%]
用于新型复方制剂中恩格列净与酒石酸美托洛尔同时分析的绿色评价和稳定性指示型HPTLC方法研究
Heena Ninama,Shaileshkumar K Koradia
Heena Ninama
BackgroundEmpagliflozin a sodium-glucose co-transporter 2 inhibitor, and Metoprolol succinate, a cardioselective β1-blocker, are co-formulated in a novel bilayer tablet currently under clinical evaluation. Reliable stability-indicating met...
The Future Trends of Artificial Intelligence and Innovative Technologies in the New Era of Pharmaceutical Sciences and Industry 4.0 [0.03%]
新时代药物科学与工业4.0背景下的人工智能及创新技术发展趋势
Phuvamin Suriyaamporn,Boonnada Pamornpathomkul,Tanasait Ngawhirunpat et al.
Phuvamin Suriyaamporn et al.
Objective: This review article outlines the transformative impact of Artificial Intelligence (AI) in the pharmaceutical sciences, focusing on its integration with modern technologies and its role in advancing medication r...
Design Expert Analysis of Tacrolimus Compatibility with Common Excipients [0.03%]
他克莫司与常用辅料相容性研究专家评审分析报告
Sara Sajjadi,Ali Shayanfar,Mohammadreza Siahi-Shadbad
Sara Sajjadi
Objective: Tacrolimus is a potent macrolide immunosuppressant widely utilized in solid organ transplantation and the management of autoimmune disorders. The current study aimed to investigate the compatibility of tacrolim...
High-throughput excipient screening using 384-well plates and a pipetting robot: assessing protein stability after freeze-drying to pre-select viable formulations [0.03%]
采用384孔板和移液机器人进行高通量辅料筛选：通过冷冻干燥后评估蛋白稳定性以预先筛选可行的处方配方
Daan Zillen,Noa N van der Ploeg,Ronald van Merkerk et al.
Daan Zillen et al.
Introduction: Formulation research benefits from high-throughput excipient screening methods, considering the ever-growing excipient space. We investigate the use of 384-well plates as freeze-drying containers and for subsequent analyses, t...
Bioequivalence and Pharmacokinetic Prediction of Oral Marketed Metformin Extended-Release Tablets in Saudi Arabia [0.03%]
沙特阿拉伯市场上口服降糖药盐酸二甲双胍缓释片的生物等效性和药代动力学预测研究
Talal S Alrashidi,Mohammed A Amin,Abdullah S Aljutyali et al.
Talal S Alrashidi et al.
Objective: The Saudi market offers dosages of metformin that have varying release rates and can lead to different pharmacological reactions. Studying formulation bioequivalences helps patients choose the optimum medicine ...
A new approach for the development of Etodolac emulgels for rheumatic arthritis cure: In vitro and in vivo assessments [0.03%]
一种治疗风湿性关节炎的新方法：艾托多拉克乳胶凝胶的开发及体内外评价
Shaaban K Osman,Ahmed M Mohammed,Khaled I Saleh et al.
Shaaban K Osman et al.
Objectives: Etodolac (ETD), an insoluble anti-inflammatory drug, undergoes first-pass metabolism, which limits its oral bioavailability. The current study presents the trials for improvement of drug solubility on one hand...