Electric-Field-Mediated Molecular Scalpel for Programmable Cleavage and Reconfiguration of Monolayer Covalent Organic Frameworks [0.03%]
电场调控分子剪刀实现二维共价有机框架的可编程剪切与重排
Guangyuan Feng,Qian Zhang,Vipin Mishra et al.
Guangyuan Feng et al.
Monolayer covalent organic frameworks (COFs) featuring reversible linkages have emerged as promising platforms for dynamic structural reconfiguration. However, achieving programmable depolymerization and reconstruction of robust imine COFs ...
Decoupling Zeolite-Confined Hydrated Protons from Bulk Alkalinity for Efficient Hydrogen Evolution [0.03%]
高效产氢的包裹在分子筛客体酸位中的水合质子与主体碱位的解耦机制研究
Tian Ke,Qingju Wang,Kevin Siniard et al.
Tian Ke et al.
The scarcity of protons in alkaline media limits many proton-coupled energy conversion processes, particularly the hydrogen evolution reaction (HER). Here, we introduce a strategy to create a confined acidic microenvironment within strongly...
Sprayable Lactococcus lactis-Nanocatalyst Gel for Postsurgical Immunomodulation in Preclinical Oral Squamous Cell Carcinoma [0.03%]
用于临床前期口腔鳞状细胞癌术后免疫调节的喷雾型乳酸链球菌-纳米催化剂凝胶
Senfeng Zhao,Bin Liu,Yesi Shi et al.
Senfeng Zhao et al.
Oral squamous cell carcinoma (OSCC) is one of the most prevalent and aggressive head and neck cancers. Emerging evidence shows that distinct microbiomes coexist with tumor and immune cells in the tumor microenvironment (TME), shaping tumor ...
Blue Shift in Electrochromic Dye Emission Indicates Distinct Electrostatic Environment at Air-Water Interfaces [0.03%]
电致变色染料发射的蓝移表明空气-水界面静电环境的独特性
Alessandra Mandala Kol,Teddy Herriman,Wendy C Salmon et al.
Alessandra Mandala Kol et al.
The electrostatic properties of gas-liquid interfaces are thought to play essential roles in microdroplet chemistry with applications ranging from atmospheric chemistry to organic reactivity and aerosolized drug delivery. In this study, we ...
Thermodynamic and Kinetic Modulation of Artificial H2O2 Photosynthesis via Spatial Control of Redox Catalytic Sites [0.03%]
空间控制氧化还原催化位点的人工H2O2光合成的热力学和动力学调控
Xu Zhang,Qixin Zhou,Chen Li et al.
Xu Zhang et al.
The thermodynamic and kinetic mismatch between oxidative and reductive half-reactions represents a central barrier in photocatalysis, largely due to the absence of well-defined and functionally differentiated active sites. Herein, we constr...
An Automation Platform for the Chemoenzymatic Synthesis of Complex Sulfated and Branched Glycans [0.03%]
糖链的化学酶法合成自动化平台
Saptashwa Chakraborty,Kyle Minder,Anthony Robert Prudden et al.
Saptashwa Chakraborty et al.
Diverse collections of well-defined glycans are needed to investigate the molecular mechanisms by which these biomolecules mediate biological and disease processes. Several automation approaches have been introduced to accelerate the enzyma...
Alberto Privitera,Alessandro Chiesa,Fabio Santanni et al.
Alberto Privitera et al.
Molecules provide a modular and chemically tunable platform for quantum information science. In recent years, significant advances have been made in enabling optical spin initialization, coherent control, and both optical and electrical rea...
In Vitro Evolution of the Adenosine A2A Receptor Based on an Antagonist Binding Using a Ribosome Display [0.03%]
基于拮抗剂结合的腺苷A2A受体的体外进化（使用核糖体展示技术）
Genki Fukasawa,Yuma Matsuoka,Duy Phuoc Tran et al.
Genki Fukasawa et al.
In vitro evolution is one of the powerful methods for altering the characteristics of a protein of interest; however, its application to membrane proteins remains challenging due to the requirement of a membrane environment in vitro. This s...
Microstructure-Mediated Electron Transfer Dominates the Photoconversion of NO2 to HONO on Soot [0.03%]
氮氧化物在碳黑表面转化为羟基硝酸盐的光化学机制研究
Shiwei Lai,Shaojie Yang,Jianwei Zheng et al.
Shiwei Lai et al.
Soot microstructure significantly influences the photochemical conversion of NO2 to HONO, and potential regulatory pathways remain insufficiently understood. Here, we systematically investigated the photochemical pathways of NO2 with soot a...
NIR-II Nanomedicine Engineered CAR-NK Cells for Precision Navigation and Potentiating Lung Cancer Immunotherapy by Remodeling Tumor Microenvironment [0.03%]
用于肺癌免疫治疗的精准导航和重塑肿瘤微环境的近红外二区纳米医学工程CAR-NK细胞
Yeneng Dai,Qihang Ding,Ze Chen et al.
Yeneng Dai et al.
Despite the prominent success against hematologic malignancies in clinical settings, chimeric antigen receptor NK (CAR-NK) cell immunotherapy is still hindered in lung cancer tumors owing to insufficient infiltration and poor immune activat...