Impact of Dietary Practices on DNA Adduct Formation by Aristolochic Acid I in Mice: Drinking Alkaline Water as a Risk Mitigation Strategy [0.03%]
饮碱性水减少 Aristolochic Acid I 鼠类模型DNA加合物形成的研究
Hong-Ching Kwok,Jiayin Zhang,Nikola M Pavlović et al.
Hong-Ching Kwok et al.
Balkan endemic nephropathy (BEN) is a chronic kidney disease associated with the consumption of aristolochic acids (AAs) through contaminated food sources. AAs are known to form DNA adducts that are implicated in tumorigenesis and kidney fi...
Metabolism Profiles of Trimethoprim in Idiosyncratic Adverse Drug Reaction-Affected Tissues [0.03%]
受药物不良反应影响的组织中特异性的代谢谱型分析
Robert T Tessman,Whitney Nolte,Priscilla Flores-Ascencio et al.
Robert T Tessman et al.
Trimethoprim (TMP) is an essential antibiotic used in combination with sulfamethoxazole to treat and prevent bacterial infections. Idiosyncratic adverse drug reactions (IADRs) to TMP occur in a small but significant percentage of the treatm...
Human APE2 and TREX2 Repair 3'-DNA-Peptide Cross-links Derived from Abasic Sites [0.03%]
人源APE2和TREX2修复来自碱基缺失位点的3′-DNA-肽交联反应
Xiaoying Wei,Joel Cepeda,Jee Min Chung et al.
Xiaoying Wei et al.
Histones react with one of the most abundant endogenous DNA lesions, the apurinic/apyrimidinic (abasic, AP) site, to form reversible but long-lived Schiff base DNA-protein cross-links at 3'-DNA termini (3'-histone-DPCs). These DPCs need to ...
Per- and Polyfluoroalkyl Substances Induce Cardiotoxicity and Alter Protein Profiles of Extracellular Matrix, Metabolism, and Mitochondrial Function in Human Cardiomyocytes [0.03%]
全氟和多氟烷基物质诱导心肌细胞毒性和细胞外基质、代谢及线粒体功能相关蛋白表达量的改变
Wenhao Zhang,Zeyu Wang,Olivia Reid et al.
Wenhao Zhang et al.
Per- and polyfluoroalkyl substances (PFAS), common environmental contaminants, can cause cardiotoxic effects particularly during fetal development. However, the effect of combined PFAS exposure, which more closely reflects real-world enviro...
Comparative Study of Molecular Descriptors and AI-Based Embeddings for Toxicity Prediction [0.03%]
基于分子描述符和AI嵌入的毒性预测比较研究
Magnus Gray,Leihong Wu
Magnus Gray
Accurate toxicity prediction is a critical component of pharmaceutical development and regulatory safety evaluation, traditionally relying on molecular descriptor-based models. This study compares the performance of descriptor-based feature...
Cannabinoid Vaping Products: Regulation, Composition, Toxicological Effects, and Emerging Research [0.03%]
cannabinoids雾化产品：监管、成分、毒理学影响及新兴研究
Charlotte A Love,Ned A Porter,Hye-Young H Kim et al.
Charlotte A Love et al.
The 2018 U.S. Farm Bill inadvertently paved the way for a market of unregulated, hemp-derived cannabinoid vaping products, including cannabidiol (CBD) and Δ8-tetrahydrocannabinol (Δ8-THC). These products contain extremely high cannabinoid...
Differential Reactivity of Airborne Quinones on Human Red Blood Cells: Insights into Their Biochemical and Morphological Alterations [0.03%]
气载醌类物质对人红细胞差异化反应性：对其生化及形态变化的见解
Neha Yadav,Jayamohan P M,Santosh Kumar Mondal et al.
Neha Yadav et al.
Airborne fine particulate matter (PM2.5) exposure has been epidemiologically linked to increased risk of cardiovascular complications, thrombosis, and hypoxia-related disorders. Quinones, prevalent constituents of PM2.5, are suspected media...
A Chemically Stable Interstrand Cross-Link Generated via a Reductive Amination Process Involving an Apurinic/Apyrimidinic Site and an Adenine Residue in Duplex DNA [0.03%]
通过还原胺化过程在双链DNA中的apurinic/apypyrimidinic位点和腺嘌呤残基之间形成的稳定的链间交联
Tanhaul Islam,Nathan E Price,Saosan Binth Md Amin et al.
Tanhaul Islam et al.
Apurinic/apyrimidinic (AP) sites are unavoidably generated in the DNA of living organisms by the spontaneous or catalyzed loss of coding nucleobases from the deoxyribose backbone. AP sites can lead to the generation of interstrand DNA cross...
RNA Oxidative Damage by the Iron-Fenton Reaction is Influenced by Bicarbonate Concentration and Ligand Strength [0.03%]
碳酸氢盐浓度和配体强度影响铁-芬顿反应介导的RNA氧化损伤
Justin C Dingman,Aaron M Fleming,Cynthia J Burrows
Justin C Dingman
Oxidative damage to RNA is associated with neurodegeneration, cardiovascular diseases, and cancer development. Studies that monitor RNA damage by H2O2 often omit the physiological buffer bicarbonate in the reaction, which fails to account f...
Maternal-Fetal Transfer and Toxicokinetics of 2,2',5,5'-Tetrachlorobiphenyl, [14C]-PCB52, Following Intratracheal Administration [0.03%]
[14C] PCB52气管给药后母体与胎儿间的转运及毒代动力学研究
Yau Adamu,Andrea Adamcakova-Dodd,Xuefang Jing et al.
Yau Adamu et al.
Despite increased recognition of the adverse impacts of PCB exposure on human health, comprehensive risk assessments, particularly regarding inhalation exposure and effects on the developing fetus, are lacking. Out of all PCB congeners, low...