Pubertal Exposure to Lambda-Cyhalothrin Disrupts Adrenal Steroidogenesis via Downregulation of AGTR1A/CYP11B2 and Apoptosis Induction [0.03%]
Wanwan Chen,Xin Liu,Hang Lin et al.
Wanwan Chen et al.
Lambda-cyhalothrin (LCT) is a pyrethroid widely employed in agriculture. However, their effects on adrenal function during puberty remain unclear. The objectives of the study are to demonstrate LCT-mediated impairments of adrenal steroidoge...
Xiaofang Zheng,Ping Fu,Yingqi Zhao et al.
Xiaofang Zheng et al.
Oxidative damage to mitochondrial DNA is closely associated with the development of various human diseases. 8-Oxo-7,8-dihydroguanine (8-oxoG) is a vital biomarker of oxidative DNA damage with a putative role as an epigenetic-like modificati...
Linde Schoenmaker,Emmelie E M van der Veer,Daan A Jiskoot et al.
Linde Schoenmaker et al.
Current methods for determining the neurotoxic potential of (agro)chemicals are not comprehensive enough, as is suggested by the increased incidence of Parkinson's disease (PD) among people exposed to certain pesticides. Mechanism-based in ...
Yuanyuan Lin,Ziying Jiang,Ying Peng et al.
Yuanyuan Lin et al.
Stiripentol (STP) is a kind of effective antiepileptic medicine, but its hepatotoxicity has been documented. However, the cause of its hepatotoxicity remains unclear. In this study, we attempted to explain its hepatotoxicity from the perspe...
New Docking, Molecular Dynamics, and QSAR Models to Predict Disruption of Human and Rat Transthyretin Function by Per- and Polyfluoroalkyl Substances (PFAS) [0.03%]
Nuno M S Almeida,Heather M Bolstad,Scott Coffin et al.
Nuno M S Almeida et al.
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemicals that require an improved understanding of the toxicity mechanisms and the development of predictive models for risk assessment. One observed effect of PFAS ...
Early ADME and Preliminary Toxicity Studies of I-152, an N-Acetyl-l-Cysteine/ S-Acetylcysteamine Conjugate [0.03%]
I-152（N-乙酰半胱氨酸/S-乙酰基胱胺缀合物）的早期ADME和初步毒性研究
Francesca Bartoccini,Aurora Valeri,Matteo Gregori et al.
Francesca Bartoccini et al.
This study aimed to estimate the ADME properties and safety of I-152, a conjugate of N-acetyl-l-cysteine (NAC) and S-acetylcysteamine (also known as S-acetyl-β-mercaptoethylamine; SMEA), linked by an amide bond. Its potent antioxidant and ...
Neuroprotection Against a Panel of Toxicants via a Novel Analog of the Natural Product Fraxinellone [0.03%]
一种天然产物塞斯酮的新类似物对抗多种毒物的神经保护作用
Anna E Bartman,Michael A Garcia-Mares,Sarah E Preston et al.
Anna E Bartman et al.
Humans are exposed to a myriad of environmental pollutants, with recent evidence indicating several of these toxicants serve as risk factors for neurodevelopmental disorders and neurodegenerative diseases. Given this, there is a need for bo...
QSAR-ME Profiler 2025: A New Software for QSA(P)R Predictions Supported by Structural Analysis [0.03%]
QSAR-ME Profiler 2025：一种新的QSA（P）R预测软件（具备结构分析功能）
Nicola Chirico,Arianna Sgariboldi,Marco Evangelista et al.
Nicola Chirico et al.
Quantitative structure-activity (property) relationships (QSA(P)Rs) are an alternative to in vivo /in vitro experiments. Over the past 20 years, QSA(P)Rs targeting various properties and activities have been developed by the QSAR research u...
Modulation of ER Stress via cAMP Signaling: Protective Role of Rolipram in Paracetamol-Induced Liver Injury [0.03%]
通过cAMP信号调控内质网应激：Rolipram在对乙酰氨基酚致肝损伤中的保护作用
Saziye Sezin Palabiyik-Yucelik,Nagihan Demirtas,Nevra Aydemir Celep et al.
Saziye Sezin Palabiyik-Yucelik et al.
This investigation sought to assess the potential protective function of the phosphodiesterase-4 (PDE) enzyme inhibitor rolipram (ROL) against paracetamol (PARA) induced liver damage, as well as any potential underlying mechanism through mo...
Correction to "1,4-Benzoquinone (PBQ) Induced Toxicity in Lung Epithelial Cells Is Mediated by the Disruption of the Microtubule Network and Activation of Caspase-3" [0.03%]
“1,4-苯醌(PBQ)通过破坏微管网络和激活Caspase-3诱导肺上皮细胞毒性”的勘误证
Amlan Das,Subhendu Chakrabarty,Diptiman Choudhury et al.
Amlan Das et al.
Published Erratum
Chemical research in toxicology. 2026 Apr 20. DOI:10.1021/acs.chemrestox.6c00165 2026