Indane-Based Chiral Aryl Chalcogenide Catalysts: Development and Applications in Asymmetric Electrophilic Reactions [0.03%]
印度烷基手性芳族硫属化物催化剂的发展及其在不对称亲电反应中的应用
Lihao Liao,Xiaodan Zhao
Lihao Liao
Asymmetric electrophilic reactions provide an ideal method for the construction of chiral molecules by incorporating one or more functional groups into the parent substrates under mild conditions. However, due to the issues of the reactivit...
Click Step-Growth Polymerization and E/ Z Stereochemistry Using Nucleophilic Thiol-yne/-ene Reactions: Applying Old Concepts for Practical Sustainable (Bio)Materials [0.03%]
点击官能团的逐步增长聚合及异构体选择性硫烯/-烯基化学：用于可持续发展材料合成的经典反应的新概念与应用
Joshua C Worch,Andrew P Dove
Joshua C Worch
Polymer sustainability is synonymous with "bioderived polymers" and the zeitgeist of "using renewable feedstocks". However, this sentiment does not adequately encompass the requirements of sustainability in polymers. In addition to recyclin...
Unraveling the Chemistry of High Valent Arylcopper Compounds and Their Roles in Copper-Catalyzed Arene C-H Bond Transformations Using Synthetic Macrocycles [0.03%]
利用合成大环分子解析高价芳基铜化合物的化学及催化铜转移官能团化反应中的作用
Qian Zhang,Shuo Tong,Mei-Xiang Wang
Qian Zhang
Recent decades have witnessed a resurgence of the study of copper-catalyzed organic reactions. As the surrogate of noble metal catalysts, copper salts have been shown to exhibit remarkable versatility in activating various C-H bonds enablin...
Differences in the Second Coordination Sphere Tailor the Substrate Specificity and Reactivity of Thiol Dioxygenases [0.03%]
第二配位 sphere差异定制了硫氧还蛋白过氧化物酶的底物特异性和反应活性
Rebeca L Fernandez,Nicholas D Juntunen,Thomas C Brunold
Rebeca L Fernandez
In recent years, considerable progress has been made toward elucidating the geometric and electronic structures of thiol dioxygenases (TDOs). TDOs catalyze the conversion of substrates with a sulfhydryl group to their sulfinic acid derivati...
Da Seul Lee,Vineet Kumar Soni,Eun Jin Cho
Da Seul Lee
A radical shift toward energy transfer photocatalysis from electron transfer photocatalysis under visible-light photoirradiation is often due to the greener prospects of atom and process economy. Recent advances in energy transfer photocata...
The Stereoselective Total Synthesis of Axially Chiral Naphthylisoquinoline Alkaloids [0.03%]
轴手性萘异喹啉生物碱的立体选择性全合成
Nasir Tajuddeen,Doris Feineis,Heiko Ihmels et al.
Nasir Tajuddeen et al.
The naphthylisoquinoline (NIQ) alkaloids are a thrilling class of natural biaryls─structurally, biosynthetically, and pharmacologically. A common feature of these metabolites is the biaryl bond between their naphthalene and isoquinoline mo...
Fenglian Qi,Ki-Jae Jeong,Jianxiao Gong et al.
Fenglian Qi et al.
Self-assembly, which enables spontaneous arrangement of objects, is of particular importance for nanomaterials in both fundamental and applied research fields. Multiple types of nanoparticle superstructures have been successfully built in h...
Bridging Known and Unknown Unknowns: From Natural Products and Their Mimics to Unmet Needs in Neuroscience [0.03%]
化未知为已知：从天然产物及其模拟物到神经科学未被满足的需求
Stephen F Martin
Stephen F Martin
Scientific excursions into the unknown are often characterized by unanticipated twists and turns that may lead in directions that never could have been predicted. Decisions made during the course of these explorations determine what we disc...
Xiaobo Pang,Pei-Feng Su,Xing-Zhong Shu
Xiaobo Pang
Transition-metal-catalyzed reductive coupling of electrophiles has emerged as a powerful tool for the construction of molecules. While major achievements have been made in the field of cross-couplings between organic halides and pseudohalid...
Autonomous Chemical Experiments: Challenges and Perspectives on Establishing a Self-Driving Lab [0.03%]
自主化学实验：建立自动驾驶实验室所面临的挑战与前景展望
Martin Seifrid,Robert Pollice,Andrés Aguilar-Granda et al.
Martin Seifrid et al.
We must accelerate the pace at which we make technological advancements to address climate change and disease risks worldwide. This swifter pace of discovery requires faster research and development cycles enabled by better integration betw...