Alessia Ghidini,Eleonora Serra,Andrea Cavalli
Alessia Ghidini
ConspectusThis Account discusses recent progress and challenges in binding free energy computations, focusing on two classes of enhanced sampling techniques: alchemical transformations and path-based methods. Binding free energy is a crucia...
Ionizable Lipid Nanoparticles for mRNA Delivery: Internal Self-Assembled Inverse Mesophase Structure and Endosomal Escape [0.03%]
可电离脂质纳米颗粒的mRNA递送：内部自组装反介观结构和溶酶体逃逸机制
Haitao Yu,Brendan P Dyett,Calum J Drummond et al.
Haitao Yu et al.
ConspectusThe clinical use of mRNA COVID-19 vaccines developed by Moderna and Pfizer-BioNTech has highlighted the critical role of ionizable lipid nanoparticles (LNPs) in the efficient loading, intracellular delivery, and cytoplasmic releas...
Theoretical Assistant Experimental Optimization for Advanced All-Solid-State Sodium Batteries [0.03%]
先进全固态钠电池理论、辅助实验优化方法研究
Xiangdan Zhang,Wenbin Li,Zhenling Wang et al.
Xiangdan Zhang et al.
ConspectusAll-solid-state sodium batteries (ASSSBs) are indispensable components as alternatives to balance the energy structure owing to high energy density, high safety, and high resource abundance. The innovation of ASSSBs technology not...
Isomer-Selective Mass Spectrometry Imaging Using Nanospray Desorption Electrospray Ionization (Nano-DESI) [0.03%]
基于纳喷脱溶电喷雾离子化（nano-DESI）的异构体选择性成像质谱技术
Sara Amer,Li-Xue Jiang,Mushfeqa Iqfath et al.
Sara Amer et al.
ConspectusMass spectrometry imaging (MSI) has transformed our ability to explore molecular distributions in biological tissues with high chemical specificity and sensitivity. Despite significant advances in this field, the absence of separa...
Dissecting the Mechanism of Biosynthesis of Sulfurated Biomolecules: The Case of tRNA Sulfuration [0.03%]
分解生物素化硫化生物分子的合成机制：tRNA硫化的例子
Sylvain Gervason,Marc Fontecave,Béatrice Golinelli-Pimpaneau
Sylvain Gervason
ConspectusSulfuration of biomolecules is a crucial biochemical process responsible for producing essential organic cofactors, coenzymes, vitamins, and other sulfurated biomolecules. In particular, thiomodified nucleosides in tRNA play a key...
Chemical Adaptation in Drug Discovery: The Medicinal Chemistry Journey of Olverembatinib and Limertinib in Overcoming Kinase Drug Resistance [0.03%]
药物发现中的化学适应性：Olverembatinib和Limertinib克服激酶耐药性的药物化学历程
Ke Ding,Yupeng Li,Yang Zhou et al.
Ke Ding et al.
ConspectusDrug resistance remains one of the biggest challenges in kinase inhibitor therapy, particularly in cancers where prolonged treatment fosters the emergence of resistant mutations. These mutations often alter amino acid residues wit...
Revealing Mechanisms in the Early Stages of Virus Infection by Single-Virus Tracking [0.03%]
单病毒追踪揭示病毒感染早期阶段的机制
Lei Du,Li-Juan Zhang,Dai-Wen Pang
Lei Du
ConspectusUnraveling the mechanisms of viral infection is crucial for controlling viral transmission and treating viral diseases. Viral infection exhibits highly complex and dynamic processes, involving diverse infection routes, multistep i...
Revealing Mechanisms in the Early Stages of Virus Infection by Single-Virus Tracking [0.03%]
单病毒追踪揭示病毒感染早期机制
Lei Du,Li-Juan Zhang,Dai-Wen Pang
Lei Du
ConspectusUnraveling the mechanisms of viral infection is crucial for controlling viral transmission and treating viral diseases. Viral infection exhibits highly complex and dynamic processes, involving diverse infection routes, multistep i...
Qihang Ding,Manlin Qi,Wen Li et al.
Qihang Ding et al.
ConspectusThe complex and dynamic microenvironments of pathological sites, including infections, tumors, and neurological disorders, impose formidable challenges on conventional therapies due to features such as iron dysregulation, localize...
Molecular Insights into Bismuth's New Applications against Antimicrobial Resistance and Coronaviruses [0.03%]
铋在抗微生物耐药和冠状病毒方面的新的应用的分子见解
Hongyan Li,Xueying Wei,Hongzhe Sun
Hongyan Li
ConspectusBismuth, a heavy metal distinguished by its low toxicity, compared to lead or mercury, has long been associated with medicine for the treatment of various conditions, notably as a key component in triple and quadruple therapies fo...