Jie Liu,Xinzhi Zhao,Peifei Liu et al.
Jie Liu et al.
The advancement of precision medicine depends critically on well-defined molecular targets. Pathologically activated fibroblasts drive disease progression in cancer, fibrosis and chronic inflammation through sustained inflammation, extracel...
Controllable and Diverse Migrations of Tetracoordinate Borons: Beyond 1,2-Shift [0.03%]
四配位硼的可控和多样迁移：超越1,2迁移反应
Xingxing Ma,Qiuling Song
Xingxing Ma
The chemistry of tetracoordinate borons has long been dominated by the classic 1,2-metalate shift, a powerful yet inherently predictable rearrangement where the migrating aptitude is dictated by the electronic bias of the substituents. Brea...
Affinity Peptide-Driven Precision Glycan Analysis: From Targeted Capture to Single-Molecule Profiling [0.03%]
亲和肽指导的精简糖链分析：从靶向捕获到单分子定位检测
Minmin Li,Guangyan Qing
Minmin Li
Glycans play pivotal roles in cell-cell communication, immune recognition, signal transduction, and pathogen-host interactions. Their versatile functions stem from extraordinary structural diversity, defined by variations in composition, li...
Single Fluorogens and Orientation-Localization Microscopy for Quantifying Chemical and Biomolecular Dynamics at the Nanoscale [0.03%]
单分子荧光和取向定位显微镜在纳米尺度上量化化学及生物分子动力学方面的应用
Yiyang Chen,Yuanxin Qiu,Matthew D Lew
Yiyang Chen
Many chemical systems look uniform only because ensemble measurements average over their most interesting molecules. Electron-transfer rates vary across electrode surfaces; lipid membranes contain nanodomains with distinct packing and fluid...
Organocatalytic Enantioselective Electrophilic C-H Sulfenylation of Arenes [0.03%]
有机催化的对映选择性亲电芳烃磺化反应
Yu-Xuan Huo,Zhi-Min Chen
Yu-Xuan Huo
Electrophilic aromatic substitution has long served as a cornerstone for C-H functionalization, yet its catalytic enantioselective variant, especially for sulfenylation, remains largely unexplored. The challenges are multifaceted: the stere...
Hugo Valdés,Belen Batanero
Hugo Valdés
Oxygen heterocycles are ubiquitous across chemistry─from epoxides that underpin bulk materials and industrial manufacturing to five- and six-membered rings that populate natural products, fragrances, agrochemicals, dyes, and modern medicin...
R Graham Cooks,Thalappil Pradeep
R Graham Cooks
We suggest that accelerated reactions in confined volumes, specifically in microdroplets that contain water in contact with air, represent a remarkable, indeed a revolutionary chemical phenomenon. This strong claim is justified by the magni...
Formal Hydride Abstraction: A Unified Photoredox Platform for Nucleophilic C(sp3)-H Functionalization [0.03%]
阳离子氢负离子 abstraction策略促进的中性自由基生成及其在sp3-C-H键氨氧化反应中的应用
James Mortimer,Patricia Z Musacchio
James Mortimer
ConspectusCarbocations are among the most versatile reactive intermediates in organic synthesis. Serving as the electrophilic linchpin for fundamental transformations such as SN1 substitutions, Friedel-Crafts alkylations, Ritter reactions, ...
Guang-Rui Si,Lin-Hua Xie,Xin Zhang et al.
Guang-Rui Si et al.
ConspectusThe development of adsorbents acting as "molecule traps" for advanced adsorption and separations on specific molecular recognition has garnered increasing attention over the past decade. Molecule trapping can be understood as stro...
Why Single-Atom Alloys (SAAs) Outperform Their Individual Metal Components in Catalysis [0.03%]
单原子合金的催化活性和选择性优于其组分金属的原因分析
Francisco Zaera
Francisco Zaera
ConspectusMuch industrial catalysis employs noble metals such as Pt, Pd, and Rh to facilitate the activation of key diatomic reactants such as H2 and O2, a requisite for the promotion of hydrogenation and oxidation reactions, respectively. ...