Generating Surprisingly Powerful Pharmacology from Chemically Induced Protein Interactions [0.03%]
基于化学诱导的蛋白质互作生成令人惊讶的强大药理学效应
Stephen M Hinshaw,Steven M Banik,Nathanael S Gray
Stephen M Hinshaw
ConspectusSmall molecules that induce proximity between proteins have transformed our ability to manipulate and study cellular processes. Beyond this, proximity-inducing small molecules and biologics are now a clinical reality with increasi...
Design and Engineering of Semiconductor-Organic Interfaces: Multilayer Synthesis on the Si(001) Surface Based on Cyclooctyne Chemistry [0.03%]
基于环辛炔化学的Si(001)表面上多层有机半导体异质结构的设计与合成
Michael Dürr,Ulrich Höfer,Ulrich Koert et al.
Michael Dürr et al.
ConspectusIn this Account, we will focus on how chemoselective strategies were employed for the controlled synthesis of organic multilayers on silicon, thus forming well-defined semiconductor-organic interfaces. We will start with the chemo...
Seungwon Lee,Geunmoo Song,Kyu-Sung Jeong
Seungwon Lee
ConspectusThe construction of synthetic counterparts that mimic the structures and functions of proteins and nucleic acids has become a central focus of research in supramolecular chemistry. Aromatic foldamers are capable of folding into se...
Genetically Encoded Photocatalysis for Spatiotemporally Resolved Mapping of Biomolecules in Living Cells and Animals [0.03%]
用于活细胞和活体动物生物分子时空解析映射的基因编码光催化技术
Yuxin Fang,Peng Zou
Yuxin Fang
ConspectusEngineered photosensitizer proteins, such as miniSOG, KillerRed, and SuperNova, have long been used for light-triggered protein inhibition and cell ablation. Compared to synthetic organic dyes, these genetically encoded tags provi...
Structural Descriptor Bridging the Microstructural Feature and Catalytic Reactivity for Rational Design of Metal Catalysts [0.03%]
基于结构表征的金属催化剂活性构效关系研究及理性设计策略
Haoxiang Xu,Jiayi Wang,Jin Liu et al.
Haoxiang Xu et al.
ConspectusMetal heterogeneous catalysis is the workhorse of the chemical industry, driving the conversion of reactants to desirable products. Traditional design approaches for metal catalysts rely on trial-and-error tests and take a lot of ...
Alkyne Benzannulations: A Powerful Tool for the Efficient Synthesis of Chiral and Achiral Nanographenes and of Graphene Nanoribbons [0.03%]
用于高效合成手性和非手性亚纳米石墨烯和石墨烯纳米带的炔烃并苯反应：一种强有力的工具
Ryan J Malone,Wesley A Chalifoux
Ryan J Malone
ConspectusPolycyclic aromatic hydrocarbons (PAHs) have become ubiquitous in the design of organic electronics due to their extended π-electron systems that give rise to potentially useful optical and electronic properties. These properties...
Stereoselective Nondirected α-C(sp3)-H Functionalization of Oxygen Heterocycles [0.03%]
氧杂环的立体选择性非导向α-碳氢官能团化反应
Yuanyuan Ping,Sheng Xu,Wangqing Kong
Yuanyuan Ping
ConspectusOxygen-containing heterocycles are increasingly recognized for their biological significance, especially in the field of drug discovery. Therefore, the enantioselective synthesis of oxygen-containing heterocycles has attracted gre...
Covalent and Strong Metal-Support Interactions for Robust Single-Atom Catalysts [0.03%]
用于稳健单原子催化剂的共价和强金属载体相互作用
Yalin Guo,Jinxia Liang,Yike Huang et al.
Yalin Guo et al.
ConspectusOver the past decade, single-atom catalysis has emerged as a cutting-edge research frontier in the field of catalysis, because of its distinctive attributes, such as optimal metal utilization, atomically precise active sites, and ...
Asymmetric Catalytic Radical Reactions Enabled by Chiral N, N'-Dioxide-Metal Complexes [0.03%]
手性N,N-二氧杂胺-金属配合物催化的不对称自由基反应
Weidi Cao,Xiaohua Liu,Xiaoming Feng
Weidi Cao
ConspectusThe strategic implementation of asymmetric catalytic radical reactions has evolved into a sophisticated methodology for constructing stereogenic centers, driven by remarkable advancements in radical generation techniques. However,...
When gem-Diborylalkanes Meet Carboxylic Acids and Their Derivatives: Enolate/Enamine Chemistry beyond Conventional Reactivity [0.03%]
当Gem-二硼烷烷与羧酸及其衍生物相遇时：超越传统反应性的烯醇化物/烯胺化学
Tongchang Fang,Bowen Ren,Chao Liu
Tongchang Fang
ConspectusThe booming progress of organoboron chemistry has unleashed a profound revolution in the field of synthetic chemistry. Among emerging organoboron reagents, gem-diborylalkanes stand out as uniquely versatile platforms that unlock u...