The Chemistry Behind and Beyond the Molecular Engineering of 1,7-Naphthiporphyrin [0.03%]
基于和超出1,7-萘基卟啉分子工程的化学原理
Min-Sung Ko,Dong-Gyu Cho
Min-Sung Ko
ConspectusThe discovery of 1,7-naphthiporphyrin was based on a specific naphthalene connectivity that disrupts naphthalene's local aromaticity, and its global aromaticity was experimentally confirmed without dispute. Its unique conjugated p...
Bioinspired Chiral Peptide-Phosphonium Salt Catalysis: From Enzymes to Cationic Small-Molecule Enzyme Mimics [0.03%]
受生物启发的手性肽-磷𬭩盐催化：从酶到阳离子小分子酶模拟物
Siqiang Fang,Zanjiao Liu,Fan Wang et al.
Siqiang Fang et al.
ConspectusEnzymes exemplify nature's catalytic mastery through precise stereochemical control and remarkable rate enhancements, yet their synthetic application remains limited by inherent vulnerabilities: thermal instability, narrow substra...
Tonglin Yang,Yanwei Tang,Ying Wei et al.
Tonglin Yang et al.
ConspectusOrganic π-conjugated molecules and polymers have emerged as some of the most promising candidates of semiconductors for future information, intelligent technology, and smart manufacturing because of their unique properties such a...
Light-Driven C(sp3)-C(sp3) Bond Functionalizations Enabled by the PCET Activation of Alcohol O-H Bonds [0.03%]
光驱动的C(sp3)-C(sp3)键官能团化反应PCET活化醇O-H键实现
Danny Q Thach,Robert R Knowles
Danny Q Thach
ConspectusMethods that enable the selective functionalization of C-C bonds offer unique opportunities for the skeletal diversification of complex molecules and provide access to unique structures without the need for de novo synthesis. Whil...
Emerging Capabilities of Nonclassical Noncovalent Interactions and Asymmetric Catalysis in Stereoselective Glycosylations and Carbohydrate Functionalizations [0.03%]
非经典非共价相互作用及不对称催化的新兴能力在立体选择性糖基化和碳水化合物功能化中的应用
Amal Tom Sebastian,Charles C J Loh
Amal Tom Sebastian
ConspectusDeriving inspiration from frontier catalytic paradigms has emerged as a major force to tackle long-standing stereoselectivity issues in carbohydrate synthesis. In particular, there is a strong momentum in the harnessing of nonclas...
Fluorinated Radicals in Divergent Synthesis via Photoredox Catalysis [0.03%]
光氧化还原催化生成氟化自由基在发散合成中的应用
Rahul Giri,Anthony J Fernandes,Dmitry Katayev
Rahul Giri
ConspectusFluorine is an essential element in pharmaceuticals, agrochemicals, and material sciences, significantly enhancing the bioactivity, metabolic stability, and physicochemical properties of organic molecules. In medicinal chemistry, ...
Nucleic Acid Nanocapsules as a New Platform to Deliver Therapeutic Nucleic Acids for Gene Regulation [0.03%]
核酸纳米胶囊作为递送治疗性核苷酸以调控基因的新平台
Suman Pal,Jenna N Cannata,Jessica L Rouge
Suman Pal
ConspectusTherapeutic nucleic acids have shown enormous potential to treat a vast number of diseases, ranging from cancers to inflammatory diseases. siRNA formulated within lipid nanoparticles (LNPs) achieved FDA approval for a rare liver d...
Hydrogen Atom Transfer Promoted by Carbon-Centered Biradicals via Energy Transfer Catalysis [0.03%]
能量转移催化促进的碳自由基正离子中间体参与的氢原子转移反应
Ben Mao,Jun Yan,Yin Wei et al.
Ben Mao et al.
ConspectusIn the past decade, visible-light-mediated photocatalysis has emerged as an applicable strategy for the generation of diverse radical species via single electron transfer (SET) and energy transfer (EnT) processes. Within this cont...
Flexible Metal-Organic Frameworks for Adsorptive Separation of Liquid Hydrocarbons [0.03%]
用于液态碳氢化合物吸附分离的柔性金属有机骨架材料
Feng Xie,Hao Wang,Jing Li
Feng Xie
ConspectusThe separation and purification of liquid hydrocarbons are vital for producing various petrochemical feedstocks. However, the structural and chemical similarities among these hydrocarbons make conventional separation methods such ...
Regulating Bacteria-Host Interactions for Disease Intervention by Covalent Conjugation of Bacterial Surface [0.03%]
通过共价连接调节细菌表面的宿主相互作用以干预疾病治疗
Mian Chen,Jinyao Liu
Mian Chen
ConspectusThe interactions between bacteria and in vivo environments are critical for microorganism-host association, which plays essential roles in host immunomodulation and nutrient metabolism. Regulating the interactions of bacteria with...