L-RNA Aptamer-Based Tools for G-Quadruplex Structure: Identification, Characterization, and Application [0.03%]
基于L-RNA适配体的G-四链体结构研究工具：识别、表征及应用
Danyang Ji,Kun Zhang,Maryana Yarshova et al.
Danyang Ji et al.
ConspectusAptamers are single-stranded DNA or RNA oligonucleotides that bind specifically and strongly to their target molecules. However, the inherent instability of natural DNA and RNA aptamers in biological environments limits their appl...
Advancing Genetically Encoded Lysine (GEK) Chemistry: From Precision Modulation to Therapeutic Innovation [0.03%]
遗传编码赖氨酸(GEK)化学研究进展：从精准调控到药物创制
Guoqing Jin,Yifan Shi,Shivangi Sharma et al.
Guoqing Jin et al.
ConspectusGenetically encoded lysine (GEK) chemistry has transformed protein engineering by enabling precise and site-specific modifications, which expand lysine's functional landscape beyond its native post-translational modifications (PTM...
Matteo Ceppatelli,Manuel Serrano-Ruiz,Marta Morana et al.
Matteo Ceppatelli et al.
ConspectusNitrides represent a class of chemical compounds of high scientific and technological relevance. Nevertheless, due to the challenging synthetic conditions, essentially related to the stability of the N2 molecule, nitrides have rem...
Mary Canzano,Gonçalo J L Bernardes
Mary Canzano
ConspectusProximity-induced chemistry (PIC) refers to the transient reactivity between two or more molecules upon physical closeness which are otherwise unreactive. Harnessed by nature to control fundamental biological processes such as tra...
Sason Shaik,David Danovich,Surajit Kalita et al.
Sason Shaik et al.
ConspectusThis Account outlines principles of electric-field-mediated chemistry, whereby oriented-external electric fields (OEEFs) function as universal "reagents" that control reactivity/selectivity and structures of molecules/clusters. Th...
Hong-Juan Feng,Ming-Yu Zhang,Lin-Han Jiang et al.
Hong-Juan Feng et al.
ConspectusPhoton upconversion, particularly triplet-triplet annihilation upconversion (TTA-UC), converts low-energy photons into higher-energy ones through multiphoton fusion, offering unique photophysical properties with broad applications...
Gabriel Maria Ingo,Cristina Riccucci,Francesca Boccaccini et al.
Gabriel Maria Ingo et al.
ConspectusNumerous metal artifacts of exceptional historical and artistic value from the Moche civilization (ca. 450 AD) were unearthed in the tomb of the Lady of Cao (El Brujo, Peru). The tomb yielded the tattooed, mummified remains of a y...
CO2 Chemical Fixation into Value-Added Heterocycles Catalyzed by Non-Noble-Metal Metal-Organic Frameworks [0.03%]
非贵金属金属有机框架催化二氧化碳合成高附加值杂环化合物
Fang-Yu Ren,Bin Zhao
Fang-Yu Ren
ConspectusThe conversion of CO2 into high-value-added chemicals represents an effective strategy for CO2 utilization. However, due to the inherent thermodynamic stability of CO2, its conversion primarily relies on harsh conditions, such as ...
Catalytic Upcycling of PET: From Waste to Chemicals and Degradable Polymers [0.03%]
PET催化升级回收：从废物到化学品和可降解聚合物
Zhenbo Guo,Yuchen Li,Meng Wang et al.
Zhenbo Guo et al.
ConspectusThe global plastic waste crisis, driven by exponential growth in plastic production, has necessitated the development of innovative approaches for recycling and upcycling. Poly(ethylene terephthalate) (PET), one of the most widely...
Developing New Strategies to Construct Pseudo-natural Macrocycles for Undruggable Targets [0.03%]
开发针对难成药靶点构建伪天然大环化合物的新策略
Han Wang,Tongyu Bi,Weibo Yang
Han Wang
ConspectusUp to 85% of human-disease-related target proteins are classified as undruggable. These targets play critical roles in disease pathogenesis and progression yet lack effective agents for therapeutic intervention. In recent years, s...