Vinylcyclopropanes as Three-Carbon Synthons in Rhodium-Catalyzed Cycloadditions: Reaction Development, Mechanistic Studies, New Inspirations, and Synthetic Applications [0.03%]
铑催化的环加成反应中作为三碳合成单元的乙烯基环丙烷：反应开发，机理研究，新的启发及合成应用
Pan Zhang,Zhi-Xiang Yu
Pan Zhang
ConspectusCyclic structures are common in natural products and pharmaceuticals, but pose major synthetic challenges. Transition metal-catalyzed cycloadditions provide a direct and efficient route to complex ring systems in a single step. Th...
Motif-Directed Oxidative Folding to Design and Discover Multicyclic Peptides for Protein Recognition [0.03%]
基序导向氧化折叠设计及发现用于蛋白质识别的多环肽化合物
Chuanliu Wu
Chuanliu Wu
ConspectusMulticyclic peptides that are constrained through covalent cross-linkers can usually maintain stable three-dimensional (3D) structures without the necessity of incorporating noncovalently interacting cores. This configuration allo...
Unimolecular Fragment Coupling and Single Carbon Atom Doping as Tools for Structural Reprogramming [0.03%]
单分子片段偶联和单碳原子掺杂作为结构重编程的工具
Hayato Fujimoto,Mamoru Tobisu
Hayato Fujimoto
ConspectusOver the past decade, the precise deletion or insertion of atom(s) within a molecular skeleton has emerged as a powerful strategy for constructing and diversifying complex molecules. This approach is particularly valuable in organ...
Selective Transformation of Biomass and the Derivatives for Aryl Compounds and Hydrogen via Visible-Light-Induced Radicals [0.03%]
可见光诱导的自由基选择性转化生物质及其衍生物制取芳香族化合物和氢气
Wen-Min Zhang,Wen-Ting Niu,Fang-Fang Tan et al.
Wen-Min Zhang et al.
ConspectusFor sustainable development, exploring renewable resources is an urgent priority. Nonfood biomass, one of the largest renewable resources on Earth, primarily comprises three key components: lignin (ca. 15-30%), cellulose (ca. 35-5...
Biological Regulation Studied in Vitro and in Cellulo with Modified Proteins [0.03%]
用修饰的蛋白体外和体内研究生物调控机制
Shengxi Chen,Larisa M Dedkova,Sidney M Hecht
Shengxi Chen
ConspectusProteins and peptides occur ubiquitously in organisms and play key functional roles, as structural elements and catalysts. Their major natural source is ribosomal synthesis, which produces polypeptides from 20 amino acid building ...
Arene and Heteroarene Functionalization Enabled by Organic Photoredox Catalysis [0.03%]
有机光氧化还原催化实现的芳烃及杂芳烃官能化反应
Zhengbo Zhu,Xuedan Wu,Zibo Li et al.
Zhengbo Zhu et al.
ConspectusAromatic functionalization reactions are some of the most fundamental transformations in organic chemistry and have been a mainstay of chemical synthesis for over a century. Reactions such as electrophilic and nucleophilic aromati...
Two-Dimensional Heteropore Covalent Organic Frameworks: From Construction to Functions [0.03%]
二维异孔共价有机框架：从构建到功能
Cheng Qian,Xin Zhao
Cheng Qian
ConspectusCovalent organic frameworks (COFs) represent a fascinating class of crystalline porous polymers constructed from organic building blocks linked by covalent bonds. Benefiting from their high crystallinity, large surface area, and e...
Reimagining Dearomatization: Arenophile-Mediated Single-Atom Insertions and π-Extensions [0.03%]
重新构想除芳化：芳族分子受体介导的单原子插入和π扩展反应
Zohaib Siddiqi,David Sarlah
Zohaib Siddiqi
ConspectusDearomatization of simple aromatics serves as one of the most direct strategies for converting abundant chemical feedstocks into three-dimensional value-added products. Among such transformations, cycloadditions between arenes and...
Detection of Analytes with the Outer Surface of Solid-State Nanochannels: From pm to μm [0.03%]
从皮米到微米：用实心纳米通道外表面检测分析物
Jing-Jing Hu,Niya Lin,Lizhen Yuan et al.
Jing-Jing Hu et al.
ConspectusAccurately simulating or sensitively monitoring specific substances, such as ions, molecules, and proteins in the life process, is essential for gaining a fundamental comprehension of the underlying biological mechanism, which has...
Aldehyde-Stabilization Strategies for Building Biobased Consumer Products around Intact lignocellulosic Structures [0.03%]
围绕完整的木质纤维结构构建生物基消费产品的醛稳定策略
Shasha Zheng,Songlan Sun,Lorenz P Manker et al.
Shasha Zheng et al.
ConspectusDwindling fossil resources and their associated environmental concerns have increased interest in biobased products. In particular, many approaches to convert lignocellulosic biomass into small-molecule building blocks are being e...