Precise Synthesis of Dual-Atom Catalysts for Better Understanding the Enhanced Catalytic Performance and Synergistic Mechanism [0.03%]
精确合成双原子催化剂以更好地了解增强的催化性能和协同作用机制
Di-Chang Zhong,Yu-Chen Wang,Mei Wang et al.
Di-Chang Zhong et al.
ConspectusDual-atom catalysts (DACs), featuring two catalytic sites in close proximity, have emerged as a new frontier in energy-related catalysis. Compared with single-atom catalysts (SACs), DACs have more space to optimize the catalytic p...
Haowen Zhou,Taras Khvorost,Anastassia N Alexandrova et al.
Haowen Zhou et al.
ConspectusChemists have a firm understanding of the concept of a functional group: a small molecular moiety that confers properties (reactivity, solubility, and chemical recognition) onto a larger scaffold. Analogously, a quantum functional...
Explaining Kinetic Isotope Effects in Proton-Coupled Electron Transfer Reactions [0.03%]
解释质子耦合电子转移反应中的动力学同位素效应
Sharon Hammes-Schiffer
Sharon Hammes-Schiffer
ConspectusProton-coupled electron transfer (PCET) is essential for a wide range of chemical and biological processes. Understanding the mechanism of PCET reactions is important for controlling and tuning these processes. The kinetic isotope...
Super-Resolution Mapping and Quantification of Molecular Diffusion via Single-Molecule Displacement/Diffusivity Mapping (SM d M) [0.03%]
基于单分子位移/扩散系数图谱的超分辨率映射及分子扩散量化方法(SMdM)
Wan Li,Ke Xu
Wan Li
ConspectusDiffusion underlies vital physicochemical and biological processes and provides a valuable window into molecular states and interactions. However, it remains a challenge to map molecular diffusion at subcellular and submicrometer ...
Inorganic Nanobiomaterials Boost Tumor Immunotherapy: Strategies and Applications [0.03%]
无机纳米生物材料增强肿瘤免疫治疗：策略与应用
Qi Meng,Binbin Ding,Ping&#x;an Ma et al.
Qi Meng et al.
ConspectusTumor immunotherapy, as a new antitumor method to fight cancer by activating or enhancing the body's own immune system, has been extensively studied and applied in clinical practice. However, as an extremely complex system, tumor ...
Hideki Yorimitsu
Hideki Yorimitsu
ConspectusAromatic rings are fundamental structural motifs found in natural products, synthetic intermediates, pharmaceuticals, agrochemicals, and functional materials. While transformations at the periphery of these rings are well-establis...
Skeletal Editing of Polymer Backbones and Its Impact Across the Polymer Lifecycle [0.03%]
聚合物主链的骨架构编辑及其对聚合物全生命周期的影响
Sydney E Towell,Mark J Jareczek,Lauren S Cooke et al.
Sydney E Towell et al.
ConspectusIn the last five years, interest in the precise modification of molecular cores─termed skeletal editing─has rapidly expanded in the Chemistry community. Beyond the intrinsic value of these transformations, skeletal editing also ...
Xingyu Liu,Enyi Zhou,Qianqian Qi et al.
Xingyu Liu et al.
ConspectusOver the past decade, RNA-guided gene editing technologies, particularly those derived from CRISPR systems, have revolutionized life sciences and opened unprecedented opportunities for therapeutic innovation. Despite their transfo...
Total Synthesis of Polycyclic Natural Products via Photoenolization/Diels-Alder Reaction [0.03%]
光促进烯醇化/狄尔斯-阿尔德反应合成并环天然产物全合成
Baochao Yang,Min Hou,Shuanhu Gao
Baochao Yang
ConspectusPolycyclic ring systems represent the most common structural features of drug molecules and natural products. Chemical synthesis of complex polycyclic molecules with multiple stereogenic centers, especially quaternary carbon stere...
Wenqing Xu,Christina M Woo
Wenqing Xu
ConspectusThe E3 ligase substrate adapter cereblon (CRBN) has garnered widespread interest from the research laboratory to the clinic. CRBN was first discovered for its association with neurological development and subsequently identified a...