Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500 [0.03%]
新型连接器使环二核苷酸的生物偶联用于STING抗体药物偶联物TAK-500的鉴定
Hong Myung Lee,Kojo Abdul-Hadi,Vicky A Appleman et al.
Hong Myung Lee et al.
STING activates the innate immune system by inducing type-1 interferon (IFN) production and has been pursued as a therapeutic option in immuno-oncology. The targeted delivery of STING agonists to CCR2+ immune cells could enhance the therape...
Bioorthogonal Probe BTD-Az Enables Sensitive and Rapid In Vivo Profiling of Protein Cysteine Sulfenylation [0.03%]
生物正交探针BTD-Az实现细胞内蛋白质半胱氨酸磺酰化的敏感而快速的成像及体内定位 profiling及体内定位翻译为in vivo profiling会更好一些，其他部分按照标题正常语序调整下： 实现活体细胞内蛋白质半胱氨酸磺酰化敏感而快速成像和定位的生物正交探针BTD-Az
Mingyou Xu,Chunxu Wang,Ruyi Liu et al.
Mingyou Xu et al.
Cysteine sulfenylation (Cys-SOH) is a transient redox-sensitive post-translational modification that regulates protein activity and cellular stress responses, yet its in vivo dynamics remain difficult to capture due to short half-life and l...
Probing the Broad-Spectrum Virus-Neutralizing Epitopes Using the High-Density Oligomannose-Conjugates and Carbohydrate Microarrays [0.03%]
基于寡聚甘露糖疫苗的广谱抗病毒中和抗体及其表位研究
Christian Toonstra,Lisa Wu,Lai-Xi Wang et al.
Christian Toonstra et al.
Following global efforts to decipher the glycome of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), we further explored the immunologically potent carbohydrates in the viral glycan shield. Specifically, we constructed a la...
Elucidating the Critical Attributes of Sodium Triacetoxyborohydride to Tune Glycoconjugation via Reductive Amination [0.03%]
阐明钠三乙酰氧基硼氢化物调节还原胺化糖基化的关键属性
Mackenzie L Smith,Sarah Sirajuddin,Adriana N Santiago-Miranda et al.
Mackenzie L Smith et al.
Pneumococcal conjugate vaccines (PCVs) have effectively enhanced immunogenicity by conjugating a carrier protein to a purified capsular polysaccharide. The degree of conjugation influences the effective size of the final conjugate, and cont...
Propiolates-Based Selective Labeling and Affinity Capture Enables High-Fidelity Transcriptome-Wide Profiling of A-to-I RNA Editing [0.03%]
基于丙二酸盐的选择性标记和亲和捕获可实现高保真全转录组A到I的RNA编辑谱分析
Jian-Feng Qin,Tong-Meng Yan,Chen Huang et al.
Jian-Feng Qin et al.
Adenosine-to-inosine (A-to-I) RNA editing is a critical post-transcriptional modification that regulates various biological processes and has been implicated in neurological diseases, cancer, and autoimmune diseases. However, current method...
Double-Responsive Metallic Magnetic Nanoparticles Based on Tumor Microenvironment "Leverage" Rebalancing for Triple Collaborative Cancer Therapy [0.03%]
基于肿瘤微环境“杠杆”再平衡的双响应金属磁性纳米颗粒的三重协同癌症疗法
Yimei Zhang,Liqun Wei,Xiaole Yin et al.
Yimei Zhang et al.
Targeted perturbation of redox balance through concurrent elevation of reactive oxygen species (ROS) production and glutathione (GSH) depletion has emerged as a therapeutic paradigm for triggering tumor cell apoptosis. Nevertheless, the con...
Mitochondria-Targeting Antimicrobial Peptide (AMP) Regulating N6-Methyladenosine (m6A) Modification to Promote Colon Cancer Ferroptosis [0.03%]
靶向线粒体抗菌肽通过调控N6-甲基腺苷促进结直肠癌铁死亡发生
Chenyu Li,Shuai Li,Linlin Lv et al.
Chenyu Li et al.
Colon cancer (COAD) is one of the common malignant tumors in the gastrointestinal tract; it is urgent to deeply study the mechanism of COAD and develop new therapeutic agents, which will provide new hope for improving the therapeutic effica...
A HCOF-Based Drug Delivery System for Cancer Therapy via Intracellular Click Chemistry [0.03%]
基于HCOF的药物递送系统通过细胞内点击化学进行癌症治疗
Xianhao Wei,Jiarui Qiao,Wenjing Wei et al.
Xianhao Wei et al.
Click reactions exhibit remarkable selectivity within biological systems, making them powerful and useful tools for synthesizing various novel anticancer drugs in biomedical fields. Utilizing the overexpressed enzyme in a tumor microenviron...
Indocyanine Green-Labeled Antibody-NOTCH2 as a New Fluorescent Molecular Imaging Probe for Gastric Cancer [0.03%]
一种新型近红外荧光标记分子探针ICG-抗体NOTCH2用于胃癌的可视化检测及成像研究
Mei Li,Jinglan Wang,Qinan Li et al.
Mei Li et al.
Gastric cancer is a malignant tumor that seriously threatens human health. Its high mortality is mainly due to delayed diagnosis, which makes early detection important for improving patient prognosis. Near-infrared (NIR) fluorescence imagin...
Live-Cell Imaging of the Binding between a Chemical Drug and Its Target Proteins Based on Intracellular Redistribution of the Target Proteins [0.03%]
基于细胞内靶蛋白重新分布的化学药物与靶蛋白结合的活细胞成像法
Jung Me Hwang,Young-Chul Shin,Enkhzul Amasanaa et al.
Jung Me Hwang et al.
In modern pharmacology, obtaining an in-depth understanding of the interaction of chemical drugs with their target proteins is essential for drug discovery and the advancement of precision medicine. However, detecting these drug-protein int...