Azidocoumarin Glycan Probes for Photoinduced Cross-Linking and In Situ Fluorescent Labeling [0.03%]
用于光交联和原位荧光标记的叠氮鸟苷糖探针
Nina Jahnke,Marc D Driessen,Georgia Partalidou et al.
Nina Jahnke et al.
Photoinduced affinity labeling for cross-linking biomolecules in close spatial proximity has become a powerful strategy in life science studies to identify interaction partners in fundamental research as well as biomarkers in applied studie...
A Cysteine-Specific Cationization Strategy for Versatile Antibody Production against Intrinsically Disordered Proteins [0.03%]
一种半胱氨酸特异性阳离子化策略，用于内在无序蛋白抗体的多样化生产
Ryui Sakaguchi,Ai Miyamoto,Rikako Kutsuma et al.
Ryui Sakaguchi et al.
Several autoantigens relevant to the immune system, especially those targeted by autoantibodies induced by antitumor responses, tend to be rich in disordered regions and are prone to aggregation. This inherent instability presents significa...
NanoBRET Tracer Development for Class I Bromodomain Target Engagement in Live Cells [0.03%]
活细胞中I类溴结构域靶向参与的NanoBRET示踪剂开发
Molly S Sneddon,Chun-Ju Tsou,Xiang Fu et al.
Molly S Sneddon et al.
Epigenetic reader proteins, such as bromodomains, are often associated with diseases such as cancer and inflammation. Bromodomain and extra-terminal (BET) bromodomain inhibitors have been studied extensively; however, non-BET bromodomains a...
DNA-Encoded Libraries (DELs) for Discovering New Molecular Probes: Application to Live-Cell Bioimaging and Personalized Theranostics [0.03%]
用于发现新分子探针的DNA编码库（DEL）：在活细胞生物成像和个性化诊疗中的应用
Julien Poupart,Sunit Kumar Jana,Sasmita Tripathy et al.
Julien Poupart et al.
While DNA-encoded libraries (DELs) are well recognized as valuable tools for the development of novel small-molecule therapeutics, their significant potential for developing new imaging probes initially received less attention. However, as ...
Coelenterazine Analog Library for Specific Imaging of Serum Albumins on Conventional and Paper Microplates [0.03%]
用于常规和纸基微孔板血清白蛋白特异性成像的腔肠素类似物库
Sung-Bae Kim,Genta Kamiya,Ryohei Nihongi et al.
Sung-Bae Kim et al.
Paper-based analytical devices (PADs) are promising platforms to achieve Point-of-Care Testing (POCT) due to their low cost, ease of operation, disposability, and simplicity of assaying. Inspired by the bioanalytical potential of marine luc...
Correction to "In Vivo Interrogation of Cell-Penetrating Peptide Function: Accumulation in Tumors and the Potential as a Specific PET Probe" [0.03%]
“有关细胞穿入肽功能的活体研究：在肿瘤内的聚集及作为特异型PET探针的应用潜能”的勘误通知
Zhan Si,Lulu Tian,Hongxin Zhou et al.
Zhan Si et al.
Published Erratum
Bioconjugate chemistry. 2026 Feb 20. DOI:10.1021/acs.bioconjchem.6c00081 2026
Neuropeptide-GPCR Regulation of the Neuroimmune Axis in Neurodegeneration: Mechanisms and Translation [0.03%]
神经退行性疾病中神经肽-GPCR调控神经免疫轴的机制及转化研究
Xiaoting Zhang,Hongying Bao,Jiayi Hu et al.
Xiaoting Zhang et al.
Chronic neuroinflammation and dysfunction of the neuro-glial-vascular unit (NGVU) are central mechanisms driving the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Neuropeptides, as key regulatory sig...
Molecular Design Strategies Enabling Activity-Based Sensing and Labeling as a Platform for Probing Enzyme Activity, Redox Regulation, and Transition-Metal Signaling [0.03%]
基于活性的传感和标记的设计策略作为探究酶活、氧化还原调控及过渡金属信号传导的技术手段
Hanna I Humpel,Alexander P Luancing,Benjamin H Shostak et al.
Hanna I Humpel et al.
Activity-based sensing and labeling (ABSL) has emerged as a powerful platform for the selective detection of transient biological analytes with high sensitivity and spatial fidelity. Here, we highlight emerging molecular design strategies t...
Efficient Inhibition of TGF-β Signaling via Cytosolic Delivery of a Smad2/3-Binding Peptide Using the Cell-Penetrating PG-Surfactant DKDKC12-K5 to Block Smad2/3 Nuclear Translocation [0.03%]
利用细胞穿透性PG表面活性剂DKDKC12-K5高效递送Smad2/3结合肽到细胞质抑制TGF-β信号转导并阻断Smad2/3核转位
Ryunosuke Suzuki,Nanami Kono,Riku Kawasaki et al.
Ryunosuke Suzuki et al.
Targeting intracellular signaling molecules that translocate to the nucleus is a promising approach for peptide-based therapeutics. Here, we focused on Smad2/3, key mediators of TGF-β signaling that act as transcription factors upon nuclea...
On-Resin DIAMSAR-Conjugated CD38-Targeted Peptides and Their Inverso and Dimeric-Inverso Analogs for PET Imaging of Multiple Myeloma [0.03%]
用于多发性骨髓瘤PET成像的CD38靶向肽及其反式和二聚体反式类似物与树脂结合的DIAMSAR连接剂
Amit Kumar Sharma,Rui Tang,Alexander Zheleznyak et al.
Amit Kumar Sharma et al.
CD38 is an established biomarker of multiple myeloma (MM), and peptide-based radiopharmaceuticals targeted to this receptor offer a route to molecularly specific imaging. In this work, we identified a novel CD38-targeted peptide sequence (H...