Inhibition of AIM2 expression enhance treatment effect of osimertinib in treatment of glioma [0.03%]
抑制AIM2表达可增强奥希替尼治疗胶质瘤的效果
Hang Wang,Hongzhuang Zhang,Qianqian Wei
Hang Wang
Introduction: Glioma is one of the most commonly tumours which occurs in the central nervous system and accounts for nearly 80% of brain tumours, with a significantly high mortality and morbidity. Epidermal growth factor ...
Inhibitor of bromodomain and extraterminal domain proteins decreases transcription of Cd33 in the brain of mice subjected to systemic inflammation; a promising strategy for neuroprotection [0.03%]
溴结构域和末端外结构域蛋白抑制剂可降低小鼠全身炎症时脑中CD33转录；一种有前景的神经保护策略
Grzegorz A Czapski,Marta Matuszewska,Magdalena Cieślik et al.
Grzegorz A Czapski et al.
The neuroinflammation is a crucial component of virtually all neurodegenerative disorders, including Alzheimer's disease (AD). The bacterial lipopolysaccharide (LPS), a potent activator of the innate immune system, was suggested to influenc...
Cytidine does not affect acute toxicity of intravenously administered choline [0.03%]
胞苷不影响静脉注射胆碱的急性毒性
Kamil Synoradzki,Maciej Swiatkiewicz,Paweł Grieb
Kamil Synoradzki
Cytidine-5'-diphosphocholine (CDP-choline) is a key precursor for the intracellular synthesis of phosphatidylcholine and other phospholipids. Following either intravenous or oral application citicoline (CDP-choline of exogenous origin) unde...
Behavioral variant of frontotemporal dementia in carriers of biallelic TREM2 variants: cases study [0.03%]
遗传双等位基因TREM2变异的额颞叶痴呆行为变异型病例研究
Anna Barczak,Mariusz Berdyński,Tomasz Gabryelewicz et al.
Anna Barczak et al.
Introduction: First reports associated mutations in triggering receptors expressed on myeloid cells 2 (TREM2) with autosomal recessive Nasu-Hakola disease characterized by painful bone cysts and progressive presenile deme...
Case Reports
Folia neuropathologica. 2024;62(2):113-119. DOI:10.5114/fn.2024.140568 2024
Long non-coding RNA LBX2-AS1 activates IL4R to promote glioblastoma metastasis and angiogenesis by binding to the transcription factor NFKB1 [0.03%]
长链非编码RNA LBX2-AS1通过与转录因子NFKB1结合激活IL4R促进胶质母细胞瘤转移和血管生成
Qiang Li,Yong Cheng
Qiang Li
Introduction: LncRNA LBX2-AS1 drives the development of various cancers, but the exact mechanism whereby LBX2-AS1 affects glioblastoma (GBM) progression is unaddressed. This study intended to delineate the regulatory mech...
The early predictive value of maternal serum PAPP-A concentration at 11-14 weeks of pregnancy for preeclampsia [0.03%]
孕11-14周母血PAPP-A浓度对预测子痫前期的价值
Qing Wang,Weiping Zhang,Wushan Li et al.
Qing Wang et al.
Introduction: To determine the expression and clinical significance of maternal serum pregnancy-associated plasma protein A (PAPP-A) in pregnant women with different degrees of preeclampsia at 11-14 weeks of gestation. ...
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of the dura mimicking meningioma: a case report and literature review [0.03%]
类黏液组织相关淋巴样组织浆细胞样边缘区淋巴瘤侵犯硬脑膜并误诊为脑膜瘤一例及文献复习
Piotr Glinka,Michał Sobstyl,Grzegorz Rymkiewicz et al.
Piotr Glinka et al.
MALT lymphoma of the dura is a very rare type of low-grade B-cell lymphoma. Little more than 100 cases have been reported in the literature to date. We report a 43-year-old woman who was referred to hospital because of a series of three ton...
Transformation of IDH-wildtype glioblastoma to gliosarcoma with features of osteosarcoma [0.03%]
IDH野生型胶质母细胞瘤向具有骨肉瘤特征的偏血管型胶质肉瘤转化
Paweł Sobczyk,Michał Sobstyl,Albert Acewicz et al.
Paweł Sobczyk et al.
Gliosarcoma (GS) is a rare variant of IDH-wildtype glioblastoma. It is classified as grade 4 in the latest WHO CNS classification of both glial and mesenchymal components. Gliosarcoma may arise de novo or secondary from glioblastoma. It occ...
Case Reports
Folia neuropathologica. 2024;62(1):96-101. DOI:10.5114/fn.2024.136020 2024
Safety of GMP-compliant iPSC lines generated by Sendai virus transduction is dependent upon clone identity and sex of the donor [0.03%]
由沙粒病毒转导产生的符合GMP规范的iPSC系的安全性取决于克隆身份和供体性别
Zuzanna Kuczynska,Pawan Kumar Neglur,Erkan Metin et al.
Zuzanna Kuczynska et al.
Human induced pluripotent stem cells (hiPSCs) are a potential source of somatic cells for cell therapies due to their ability to self-renew and differentiate into various cells of the body. To date, the clinical application of hiPSCs has be...
A current view of mitochondria damage and the diversity of lipopigment inclusions in neuronal ceroid lipofuscinose type 2 from rectal biopsy [0.03%]
视神经萎缩脂褐素病2型肠道活检的线粒体损伤及脂色素包涵体多样性的一项研究观点摘要
Paulina Felczak,Aleksandra Kuźniar-Pałka,Agnieszka Ługowska et al.
Paulina Felczak et al.
Neuronal ceroid lipofuscinoses (NCLs) are a growing group of neurodegenerative storage diseases, in which specific features are sought to facilitate the creation of a universal diagnostic algorithm in the future. In our ultrastructural stud...
Case Reports
Folia neuropathologica. 2024;62(1):21-31. DOI:10.5114/fn.2023.133795 2024