Effects of dexmedetomidine on pain threshold, memory ability, and neurological function in sleep-deprived rats through expression of PSD95 protein and the phosphorylation level of the PI3K/AKT pathway [0.03%]
右美托咪啶通过PSD95蛋白表达和PI3K/AKT信号通路磷酸化水平影响睡眠剥夺大鼠痛阈、记忆能力及神经功能损伤的研究
Minru Zhang,Fang Li,Min Jia
Minru Zhang
Introduction: The study aimed to observe the effects of different doses of dexmedetomidine (Dex) on pain threshold, memory, and neurological ability in rats with sleep deprivation. ...
MUC1 overexpression in glioma correlated with tumor malignancy and poor prognosis [0.03%]
MUC1在胶质瘤中的高表达与肿瘤恶性度及预后不良有关
Abdul Wahab Jamali,Arshad Mehmood,Shiyang Zhang et al.
Abdul Wahab Jamali et al.
Mucin 1 (MUC1), a transmembrane glycoprotein, is aberrantly expressed in multiple cancers and implicated in tumor progression. This study investigated MUC1 expression in glioma tissues and cell lines, its correlation with tumor malignancy, ...
MK-2206 dihydrochloride ameliorates the neuronal function in spinal cord injured rats by reducing oxidative stress and modulating the PI3K/Akt pathway [0.03%]
MK-2206二盐酸盐通过减少氧化应激和调节PI3K/Akt通路改善脊髓损伤大鼠的神经元功能
Jinjuan Wang,Juanrong Zhou,Alok Tripathi
Jinjuan Wang
Introduction: Spinal cord injury (SCI) is one of the major causes of paralysis and physical inability, and its management remains a challenge. The present study evaluated the effect of MK-2206 dihydrochloride in rats with...
Neuroectodermal interleukin 12 signaling attenuates spinal cord inflammation and demyelination [0.03%]
神经外胚叶白细胞介素12信号转导可减轻脊髓炎症和脱髓鞘现象
Arshad Mehmood,Miraj Din,Muhammad Munawer et al.
Arshad Mehmood et al.
Introduction: Interleukin 12 (IL-12) is a driver of type 1 immunity. Interleukin 12 reduces inflammation in an autoimmune condition in the spinal cord. The aim of this study was to investigate the therapeutic effect of IL...
Role of apocynin in alleviation of oxidative stress and neuronal autophagy after traumatic brain injury by activating the PI3K/Akt/Nrf2 pathway in rats [0.03%]
阿朴菲尼通过激活PI3K/AKT/Nrf2信号通路缓解创伤性脑损伤后氧化应激及神经元自噬的作用研究
Yan Feng,Yaru Ju,Ming Yang et al.
Yan Feng et al.
Introduction: The study aimed to determine whether apocynin (APO) can protect neurons in rats with traumatic brain injury (TBI) by activating the PI3K/Akt/Nrf2 pathway, acting as an antioxidant, and suppressing autophagy....
TUG1 suppresses neural repair subsequent to cerebral hemorrhage via the miR-381-3p/BDNF axis [0.03%]
TUG1通过miR-381-3p/BDNF轴抑制脑出血后的神经修复
Fei Li,Xin Zhang,Hong Jiang et al.
Fei Li et al.
Intracerebral hemorrhage (ICH) has a high rate of death and disability. LncRNA-TUG1 is essential for the pathological changes secondary to ICH. The purpose of this work was to investigate the possible mechanism by which TUG1 inhibits neural...
USP22 overexpression mitigates spinal cord injury via NLRP3 pathway modulation [0.03%]
USP22过表达通过调节NLRP3途径缓解脊髓损伤
Ming-Chen Yu,Xiao-Lin Li,Shuai-Jin Lu et al.
Ming-Chen Yu et al.
Introduction: The purpose of this study was to explore the effect of ubiquitin-specific protease (USP) 22 overexpression on spinal cord injury (SCI) in rats and its potential mechanism, to assess its role in the recovery ...
The role of synaptic plasticity in Alzheimer's disease: from molecular mechanisms to therapeutic targets [0.03%]
阿尔茨海默病中突触可塑性的作用：从分子机制到治疗靶点
Yunyun Li,Sichong Li,Jing Ma et al.
Yunyun Li et al.
Alzheimer's disease (AD) is characterized by a complex pathophysiology, involving abnormal aggregation of amyloid b (Ab) and tau proteins, neuroinflammatory responses, and significant synaptic dysfunction, which collectively contribute to c...
Rapidly growing glioblastoma multiforme at the cervicomedullary junction - a diagnostic and neuroradiological challenge [0.03%]
迅速增长的顶叶胶质母细胞瘤-诊断和神经放射学挑战
Magdalena Konopko,Michał Sobstyl,Paweł Jezierski et al.
Magdalena Konopko et al.
Brainstem gliomas in adults are a rare and heterogeneous group of brain tumours, which account for less than 2% of all adult gliomas and usually involve the pons (60-63%). The medulla oblongata and the midbrain are the least common location...
Case Reports
Folia neuropathologica. 2025;63(4):426-435. DOI:10.5114/fn.2025.158261 2025
Tumor-suppressive role of miR-129-5p in gliomas through downregulation of CCND1 [0.03%]
miR-129-5p通过下调CCND1在胶质瘤中的肿瘤抑制作用
Tao Teng,Min Zhang
Tao Teng
Introduction: Gliomas are among the most aggressive brain tumors, with limited treatment options and poor patient outcomes. Recent studies suggest that miRNAs play a crucial role in tumor development and progression. This...