Immune reconstitution for the treatment of myasthenia gravis: the focus on cladribine [0.03%]
免疫细胞重建治疗重症肌无力：克拉屈滨的应用
Konrad Rejdak,Dariusz Baranowski,Paweł Grieb
Konrad Rejdak
Autoimmune diseases (AID) such as multiple sclerosis, rheumatoid arthritis, type 1 diabetes, inflammatory neuropathies, and some 100 other conditions, affect 5-10% of the global population, and their incidence is increasing, particularly in...
Diagnostic difficulties in progressive multifocal leukoencephalopathy: a case report [0.03%]
进行性多灶性白质脑病的诊断难题——一例报告
Angelika Stapińska-Syniec,Michał Sobstyl,Katarzyna Kurowska et al.
Angelika Stapińska-Syniec et al.
Progressive multifocal leukoencephalopathy (PML) is a demyelination disease of the central nervous system (CNS) caused by viral infection with John Cunningham polyomavirus (JC virus, JCV). PML affects mainly patients with immunodeficiency. ...
TREM2/DAP12 complex promotes proliferation and invasion of glioma cells via the PI3K-AKT signaling pathway [0.03%]
TREM2/DAP12复合体通过PI3K-AKT信号通路促进胶质瘤细胞的增殖和侵袭
Zhitong Deng,Xingming Zhong,Yong Cai et al.
Zhitong Deng et al.
Introduction: Triggering receptor expressed on myeloid cells 2 (TREM2), part of the immunoglobulin superfamily, is implicated in various malignancies. However, its role in glioma formation remains unclear. Our study uncov...
Factors influencing hemorrhagic transformation after mechanical thrombectomy for acute anterior circulation large vessel occlusion stroke and prediction modeling [0.03%]
急性前循环大血管闭塞卒中机械取栓后出血转化的影响因素及预测模型研究
Linyu Zhou,Hong Yu,Jianbing Bai et al.
Linyu Zhou et al.
Introduction: The aim was to explore the factors influencing hemorrhagic transformation (HT) after mechanical thrombectomy (MT) in acute anterior circulation large vessel occlusion stroke (ALVOS) and establish a correspon...
Lipoic acid remodels neurovascular units through the AMPK/NLRP3 signaling pathway after cerebral infarction [0.03%]
左旋肉碱通过AMPK/NLRP3信号通路重塑脑梗死后神经血管单元
Yaoru Li,Kai Yu,Lan Zhang et al.
Yaoru Li et al.
Introduction: Ischemic stroke (IS) is a disease caused by blood circulation disorders in the brain, ischemia, and hypoxia, resulting in ischemic necrosis or softening of localized brain tissue. Lipoic acid (ALA) is effect...
L1 modulates protein kinase D1 (PKD1) phosphorylation during H2O2-induced cell senescence [0.03%]
L1调节H2O2诱导的细胞衰老过程中蛋白激酶D1(PKD1)磷酸化作用
Xia Mi,Yu Peng,Heng Wu et al.
Xia Mi et al.
Age-dependent oxidative stress is considered to be involved in degenerative processes in age-related neurodegenerative disorders. The L1 cell adhesion molecule (L1CAM or L1) plays an essential role in the regeneration process following neur...
Intraspinal collision tumor comprising a schwannoma and ependymocytoma: a rare case study and literature review [0.03%]
脊髓内神经鞘瘤和ependymocyton合并发生罕见病例报告及文献复习
Zhiwu Wu,Qinglin Zhong,Zhi Wang et al.
Zhiwu Wu et al.
Collision tumors, a rare phenomenon wherein two tumors with different histological features appear in the same anatomical region, present a challenging clinical diagnosis, particularly in the context of intraspinal collision tumors. This st...
Molecular sequencing and phenotyping study of chemokines CCL2, CCL5, and CXCL10 in patients with neuroinflammation multiple sclerosis [0.03%]
神经炎症多发性硬化患者的细胞因子CCL2、CCL5和CXCL10的分子测序及表型研究
Ahmed Salim,Ihsan AlSaimary,Amal Adil Kasid Alsudany
Ahmed Salim
Introduction: A molecular sequencing and phenotyping study was conducted on chemokines CCL2, CCL5, and CXCL10 to assess the relation to multiple sclerosis (MS). ...
Targeting brain injury in sepsis: How remimazolam modulates the TLR4/NF-κB pathway in rats [0.03%]
针对脓毒症脑损伤的机制研究及右美托咪定干预的效果评价：TLR4/NF-κB信号通路的作用及其机制研究
Quan-Hui Dong,Xiao-Shi Liu,Shu-Ting Liu et al.
Quan-Hui Dong et al.
Sepsis-associated brain injury can lead to severe neurobehavioral and cognitive impairments due to inflammation, oxidative stress, and blood-brain barrier (BBB) dysfunction. Remimazolam (RM), a novel benzodiazepine, may have therapeutic pot...
Comprehensive analysis of ferroptosis and its correlation with peripheral immune infiltration in epileptic patients [0.03%]
癫痫患者的铁死亡综合分析及其与外周免疫浸润的相关性研究
Dongjuan Yuan,Zhenzhen Qu,Zhuofeng Mao et al.
Dongjuan Yuan et al.
Introduction: Aim of the study was to explore the association between ferroptosis genes in peripheral blood and immune infiltration in epileptic patients. ...