Formulation dependent pharmacokinetics, bioavailability and renal toxicity of a selective cyclooxygenase-1 inhibitor SC-560 in the rat [0.03%]
选择性环氧合酶-1抑制剂SC-560的药动学、生物利用度及肾毒性的剂型依赖性研究（英文）
Xiao Wei Teng,Abdallalah K M Abu-Mellal,Neal M Davies
Xiao Wei Teng
Purpose: To delineate formulation dependent pharmacokinetics and bioavailability of SC-560, a relatively new cycloooxygenase-1 (COX-1) specific inhibitor, in the rat and examine its influence on the renal tubular enzyme, ...
Correlation of photosensitizer delivery to lipoproteins and efficacy in tumor and arthritis mouse models; comparison of lipid-based and Pluronic P123 formulations [0.03%]
光敏剂递送与脂蛋白的相关性及在肿瘤和关节炎小鼠模型中的疗效；基于lipid和Pluronic P123形式的比较研究
Rubinah K Chowdhary,Isha Sharif,Namrata Chansarkar et al.
Rubinah K Chowdhary et al.
Purpose: The purpose of this study was the use of animal models to demonstrate the importance of drug delivery (verteporfin) to plasma lipoproteins in order to attain efficacy of photodynamic therapy (PDT) in vivo. ...
Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats [0.03%]
聚氧乙烯-聚氧丙烯嵌段共聚物407对大鼠脂质代谢调节酶活性的影响
Kishor M Wasan,Ramaswamy Subramanian,Mona Kwong et al.
Kishor M Wasan et al.
Purpose: Recently, the P-407-treated mouse was established as a useful animal model of hyperlipidemia and atherosclerosis. The present study was aimed to determine whether P-407-induced hyperlipidemia in the rat is associ...
Zhaolin Wang,H T Chen,Wilson Roa et al.
Zhaolin Wang et al.
Purpose: A nebulized aerosol formulation of the anti-cancer agent farnesol is developed and shown to induce cell death of human lung cancer cells in vitro. ...
Stephen Law,Weiqiu Wu
Stephen Law
Purpose: This paper evaluates a pilot project to determine the desirability of implementing a reimbursement model for pro-active interventions. A drug plan administration conducted an experiment in which a pharmacist coul...
Agatha W K Ng,Kishor M Wasan,Gabriel Lopez-Berestein
Agatha W K Ng
Purpose: The purpose of this review article is to review the development of a number of liposomal polyene antibiotics. Background: In t...
M K Chourasia,S K Jain
M K Chourasia
Purpose: Although oral delivery has become a widely accepted route of administration of therapeutic drugs, the gastrointestinal tract presents several formidable barriers to drug delivery. Colonic drug delivery has gained...
Co-encapsulation of two plasmids in chitosan microspheres as a non-viral gene delivery vehicle [0.03%]
Suna Ozbas-Turan,Cenk Aral,Levent Kabasakal et al.
Suna Ozbas-Turan et al.
Purpose: The aims of this study are to encapsulate two different plasmid DNAs (pGL2 and pMK3) in the same microsphere structure and to investigate in vivo transfection characteristics of chitosan microspheres. Furthermore...
Tanveer Ahmad Khan,Kok Khiang Peh
Tanveer Ahmad Khan
Purpose: To investigate the wound healing efficacy of two chitosan films, Chit-AA and Chit-LA, in comparison with a commercial preparation, Omiderm, using punch biopsy wounds in rats. ...
Rubinah K Chowdhary,Isha Shariff,David Dolphin
Rubinah K Chowdhary
Purpose: The purpose of this study was to examine the transfer of verteporfin (BPDMA) from its lipid based formulation to serum proteins. Methods: ...