Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen [0.03%]
用于评价药物生物利用度的 dissolution-permeation 方法研究——以萘普生为例
Andrejs Sitovs,Katarina Gurkina,Liga Petersone et al.
Andrejs Sitovs et al.
Objectives: Dissolution and/or release profile alone are insufficient to predict the in vivo absorption of poorly soluble drugs. Thus, permeation test becomes a critical component for biopharmaceutical assessment. Current...
Practical considerations for managing patients being treated with topical roflumilast [0.03%]
托法米利治疗患者的管理要点
Sameh Hanna,Ahmad Chehade,Christina Han et al.
Sameh Hanna et al.
Topical roflumilast, available in 0.3% cream, 0.15% cream, and 0.3% foam formulations, is a novel, highly potent phosphodiesterase-4 (PDE4) inhibitor that was recently approved in Canada for the treatment of plaque psoriasis, atopic dermati...
Artificial intelligence directed computational protein design: lessons from COVID-19 for pandemic-ready vaccines and antibody therapeutics [0.03%]
人工智能指导的计算蛋白质设计：新冠疫情对大流行病疫苗和抗体疗法的启示
Rahul Kaushik,Suyong Re
Rahul Kaushik
Artificial intelligence (AI) directed computational protein design has emerged as a transformative force in modern therapeutic discovery, reshaping how vaccines and antibody-based interventions are conceived, optimized, and deployed against...
Qualitative phytochemical profiling, antioxidant activity, and development of a water-in-oil cream containing combined oil and water infusions of frankincense resin (Boswellia spp.): a preliminary in vitro study [0.03%]
乳香树脂（Boswellia spp。）含油和水提取物的水包油膏的定性植物化学特征，抗氧化活性及体外初步研究
Shamama Javed,Ahmad Salawi,Sivakumar S Moni et al.
Shamama Javed et al.
Background: Frankincense (gum olibanum, Boswellia spp.) is an oleo-gum resin widely used in traditional medicine and cosmetics owing to the presence of volatile oils and pentacyclic triterpenic acids (boswellic acids) wit...
Ketamine enhancement of dexmedetomidine attenuation of methamphetamine-induced agitation in rats [0.03%]
氯胺酮增强右美托咪定对甲基苯丙胺致大鼠兴奋的作用研究
Madhuri Budamkayala,Jyostna Yalakala,Madison B Skeen et al.
Madhuri Budamkayala et al.
Methamphetamine (METH)-induced agitation, a major concern in acute METH intoxication, is currently treated with benzodiazepines. Due to current polysubstance use patterns in METH consumption, this treatment may fatally exacerbate respirator...
Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients [0.03%]
基于体积吸收式毛细管采样技术的他克莫司和霉酚酸酯移植受者用药浓度监测及其血细胞比容校正方法评估研究
Liang Juan,Chih-Ning Cheng,Wen-Chi Chang et al.
Liang Juan et al.
Objectives: Mycophenolic acid (MPA) and tacrolimus (TAC) exhibit substantial pharmacokinetic variability, and volumetric absorptive microsampling (VAMS) offers a minimally invasive alternative for therapeutic drug monitor...
Integrative deep learning strategies to enhance early-stage drug discovery: optimizing computational structure-activity modeling for pharmacotherapeutic innovation [0.03%]
整合深度学习策略以增强早期药物发现：优化计算构效关系模型以促进药物治疗创新
Sarah Rezazi,Cherif Si-Moussa,Salah Hanini
Sarah Rezazi
The integration of computational intelligence into therapeutic development is increasingly important for accelerating early-stage drug discovery and improving compound prioritization. In this study, we developed an optimized neural network-...
Career commitment and professional satisfaction among Romanian pharmacy graduates: a nationwide cross-sectional survey [0.03%]
罗马尼亚药学毕业生的职业承诺和专业满意度全国横断面调查
Marius Călin Cherecheş,Aura Rusu
Marius Călin Cherecheş
Introduction: Professional satisfaction is a key determinant of career commitment and workforce sustainability and retention in the pharmacy sector. The study examines professional satisfaction among Romanian pharmacy gra...
Rethinking asthma therapy, part 2: transdermal strategies for adjunct asthma and allergy treatments [0.03%]
从透皮策略入手重新考虑哮喘的治疗（第二部分）：联合使用透皮疗法治疗哮喘和过敏
Joseph Correa,Nicole K Brogden
Joseph Correa
Asthma and allergies affect millions of people globally. Avoiding triggers and allergens is a basic management technique for all asthma subtypes (>80% of asthma patients also suffer from allergies), and pharmacological treatment is the corn...
Rethinking asthma therapy, part 1: transdermal delivery of β2-agonists [0.03%]
哮喘治疗新思路（一）：β₂肾上腺素受体激动剂透皮给药疗法
Joseph Correa,Nicole K Brogden
Joseph Correa
Asthma and allergies are closely related conditions affecting millions of people around the world. Current treatment options cover many classes of drugs for both acute and ongoing conditions. β2-agonists, leukotriene modifiers, and cortico...