Pharmacokinetics of intravenously administered liposomal all-trans-retinoic acid (ATRA) and orally administered ATRA in healthy volunteers [0.03%]
健康志愿者静脉注射全反式维甲酸脂质体和口服全反式维甲酸后的药代动力学特征研究
Bulent Ozpolat,Gabriel Lopez-Berestein,Peter Adamson et al.
Bulent Ozpolat et al.
Purpose: To determine single-and multiple-dose pharmacokinetics of liposomal-all- trans -retinoic acid (Atragen) following intravenous and oral ATRA (Vesanoid) administration in healthy volunteers. ...
Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery [0.03%]
作为控释药物传递体系的聚合作物、疏水及亲水聚合物之比较评估研究
Md Selim Reza,Mohiuddin Abdul Quadir,Syed Shabbir Haider
Md Selim Reza
Purpose: The present study was undertaken to investigate the effect of plastic, hydrophilic and hydrophobic types of polymers and their content level on the release profile of drug from matrix systems. As the physico-chem...
Preparation and in vitro evaluation of chitosan matrices for colonic controlled drug delivery [0.03%]
用于结肠定位给药的壳聚糖控释体系的体外研究
Ylenia Zambito,Giacomo Di Colo
Ylenia Zambito
Purpose: The work was aimed at studying in vitro the release of 5-aminosalicylic acid (5-ASA) or diclofenac sodium (DS) from matrices based on chitosan (Ch) or Ch hydrochloride (Ch-HCl), destined to be introduced into ent...
Ambikanandan Misra,S Ganesh,Aliasgar Shahiwala et al.
Ambikanandan Misra et al.
The brain is a delicate organ, and evolution built very efficient ways to protect it. Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Many existing pharmaceuticals...
Effect of cannulation surgery and restraint stress on the plasma corticosterone concentration in the rat: application of an improved corticosterone HPLC assay [0.03%]
改良的皮质酮HPLC测定法在大鼠导管手术和禁锢应激对血浆皮质酮浓度影响中的应用研究
Spencer Ling,Fakhreddin Jamali
Spencer Ling
Purpose: Stress increases plasma corticosterone concentration in rats. We studied the time-course of plasma corticosterone post jugular vein cannulation, a potential stress producing process, and after 1 h restraint stres...
Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetration [0.03%]
聚正丁基氰基丙烯酸酯(PNBCA)纳米囊作为NSAIDs载体：体外释放和皮肤渗透的体内研究
Shozo Miyazaki,Akie Takahashi,Wataru Kubo et al.
Shozo Miyazaki et al.
Purpose: The aim of this work was to prepare poly n-butylcyanoacrylate (PNBCA) nanocapsules loaded with indomethacin and to evaluate the ability of this carrier system to deliver the drug systemically after its topical ap...
Therapeutic and hemolytic evaluation of in-situ liposomal preparation containing amphotericin - beta complexed with different chemically modified beta - cyclodextrins [0.03%]
负载不同化学修饰β-环糊精复合阿米卡星脂质体的制备及其药理和溶血评价
K K Chakraborty,S R Naik
K K Chakraborty
Purpose: The objective of this study was to evaluate therapeutic and haemolytic effects of liposomal preparation derived from proliposome entrapping inclusion complex of amphotericin B (AmB) with the chemically modified b...
HPLC determination of amoxicillin comparative bioavailability in healthy volunteers after a single dose administration [0.03%]
高效液相色谱测定健康志愿者单剂量给药后氨苄西林相对生物利用度的方法
Luis Renato Pires de Abreu,Rodrigo Mas Ortiz,Silvana Calafatti de Castro et al.
Luis Renato Pires de Abreu et al.
Purpose: An accurate, precise and sensitive HPLC assay was developed for the determination of amoxicillin in human plasma samples, to compare the bioavailability of two amoxicillin capsule (500mg) formulations (Amoxicilin...
Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic [0.03%]
紫藤属植物中三取代苯并黄酮类化合物可削弱苯二氮卓成瘾性：一种无致畸的抗焦虑成分
Kamaldeep Dhawan,Sanju Dhawan,Sumit Chhabra
Kamaldeep Dhawan
Purpose: A tri-substituted benzoflavone moiety (BZF) recently isolated from the methanol extract of aerial parts of the plant Passiflora incarnata Linneaus had exhibited encouraging results in countering the dependence pr...
Li Hui Zhen
Li Hui Zhen
Purpose: This article is used to give a brief overview for people who would like to submit a drug registration application in China, or for those who would like to get a broader international drug registration perspective...