Involvement of nitric oxide in fading of 5-hydroxytryptamine-induced vasocontraction in rat isolated vena portae smooth muscle [0.03%]
一氧化氮参与5-羟色胺引起的分离褐鼠门静脉平滑肌血管收缩的耗竭效应
J Y Datté,M A Offoumou
J Y Datté
Purpose: The aim of the present study was to investigate a nitric oxide (NO) involvement in the mediation of a 5-HT-induced vasoconstrictions response in the rat portal vein in vitro. ...
The antinociceptive activities of 1-(4-aryl-2-thiazolyl)-3,5-disubstituted-2 pyrazolines in mouse writhing test [0.03%]
一类取代噻唑基吡挫啉衍生物的抗痛作用研究
Abbas Shafiee,Maryam Bagheri,Maryam Shekarchi et al.
Abbas Shafiee et al.
Purpose: Sympathetic nervous system stimulation, which releases noradrenalin, influences the nociceptive activity that develops after tissue injury. The alpha2-adrenergic agonist, clonidine, produces analgesia through a c...
A comparison of gastrointestinal permeability induced by diclofenac-phospholipid complex with diclofenac acid and its sodium salt [0.03%]
一种新型的依托度酸磷脂复合物与依托度酸及其钠盐对胃肠道通透性影响的比较研究
Tahereh Khazaeinia,Fakhreddin Jamali
Tahereh Khazaeinia
Purpose: Gastrointestinal (GI) side effects of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac may be reduced if it is administered as a complex with phospholipid. The upper and lower GI permeability induced by...
Application of a new high performance liquid chromatography method to the pharmacokinetics of dibudipine in rats [0.03%]
高效液相色谱法在二丁酰环磷腺苷钙药动学研究中的应用
Shahab Bohlooli,Fariborz Keyhanfar,Saeed Ghiaee et al.
Shahab Bohlooli et al.
Purpose: To develop a HPLC method for assay of dibudipine in biological fluids and to study its pharmacokinetics in the rat. Methods: H...
Influence of storage conditions and type of plasticizers on ethylcellulose and acrylate films formed from aqueous dispersions [0.03%]
储存条件和增塑剂类型对乙基纤维素和丙烯酸酯膜性质的影响
Paul W S Heng,L W Chan,K T Ong
Paul W S Heng
Purpose: To investigate the influence of storage conditions and types of plasticizers on the properties and stability of ethylcellulose and polymethacrylate films and to elucidate the mechanism for the changes observed. ...
Protection of pancreatic beta-cell by the potential antioxidant bis-o-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes [0.03%]
双羟基肉桂酰甲烷保护糖尿病实验中胰岛β细胞的抗氧化作用及类天然茋的作用
Anusuya Srivivasan,Venugopal P Menon,Viswanathan Periaswamy et al.
Anusuya Srivivasan et al.
Purpose: To evaluate the antioxidant defense by bis-o-hydroxycinnamoylmethane, analogue of the naturally occurring curcuminoid bis-demethoxycurcumin in streptozotocin induced diabetes in male Wistar rats and its possible ...
Preparation and in vitro transfection efficiency of chitosan microspheres containing plasmid DNA:poly(L-lysine) complexes [0.03%]
含质粒DNA:聚赖氨酸复合物的壳聚糖微球的制备及体外转染效率研究
Cenk Aral,Julide Akbuga
Cenk Aral
Purpose: Studies on DNA complexes with cationic polymers are prompted by the search for nonviral DNA carriers for gene therapy. Among them, poly(L-Lysine) (PLL) has been extensively studied. On the other hand, these syste...
Permeation prediction of M100240 using the parallel artificial membrane permeability assay [0.03%]
利用并行人工膜通透性试验预测M100240的通透性
Kin-Kai Hwang,Nancy E Martin,Lan Jiang et al.
Kin-Kai Hwang et al.
Purpose: Kansy et al first introduced the Parallel artificial membrane permeation assay (PAMPA) in 1998. In this system, the permeability through a membrane formed by a mixture of lecithin and an inert organic solvent on ...
Chemotherapy induced gastrointestinal toxicity in rats: involvement of mitochondrial DNA, gastrointestinal permeability and cyclooxygenase -2 [0.03%]
化疗引起的大鼠胃肠毒性：线粒体DNA、胃肠通透性和环氧合酶-2的参与
Jaime A Yáñez,Xiao Wei Teng,Kathryn A Roupe et al.
Jaime A Yáñez et al.
Purpose: The gastrointestinal damage induced by xenobiotics is occurring more frequently and with greater toxicological significance than previously thought. Although there are some preliminary clinical studies and report...
Measurement of nitric oxide in murine Hepatoma Hepa1c1c7 cells by reversed phase HPLC with fluorescence detection [0.03%]
反相高效液相色谱-荧光检测法测定小鼠肝癌Hepa 1c1c7细胞中一氧化氮
Negar Gharavi,Ayman O S El-Kadi
Negar Gharavi
Purpose: Nitric oxide (NO) is produced by various cell types in picomolar to nanomolar range and has important roles in a variety of biological functions. The aim of the present study was to investigate a sensitive and re...