Liposomal prilocaine: preparation, characterization, and in vivo evaluation [0.03%]
普鲁卡因脂质体的制备、表征及体内评价
Cíntia Maria Saia Cereda,Daniele Ribeiro de Araujo,Giovana Bruschini Brunetto et al.
Cíntia Maria Saia Cereda et al.
Purpose: This study reports the development and in vivo evaluation of a liposomal system for the local anesthetic, prilocaine. Methods: ...
Comparison of urinary excretion of phenolsulfonphthalein in an animal model for Wilson's disease (Long-Evans Cinnamon rats) with that in normal Wistar rats: involvement of primary active organic anion transporter [0.03%]
Wilson病动物模型(Long-Evans Cinnamon大鼠)与正常Wistar大鼠尿酚红排泄的比较：主要有机阴离子转运体的作用
Shirou Itagaki,Soji Shimamoto,Takeshi Hirano et al.
Shirou Itagaki et al.
Purpose: The aim of this study was to determine the cause of the decline in phenolsulfonphthalein (PSP) excretion in Long-Evans Cinnamon (LEC) rats. Metho...
Cyclooxygenase-3: axiom, dogma, anomaly, enigma or splice error?--Not as easy as 1, 2, 3 [0.03%]
环氧化酶-3：公理、信条、反常、谜或剪接错误？——不仅仅是1，2，3的事
Neal M Davies,Renee L Good,Kathryn A Roupe et al.
Neal M Davies et al.
A continued need to develop safe and effective analgesics and anti-inflammatory drugs fuels the ongoing investigations of cyclooxygenase (COX). In addition, a long unanswered question in the biomedical arena revolves around the mechanism of...
Aidan Hollis
Aidan Hollis
Purpose: This article compares pharmaceutical prices paid by governments in the United States and Canada. Methods: The comparator price...
In vitro characterization and delivery of chitosan-DNA microparticles into mammalian cells [0.03%]
壳聚糖-DNA微粒的体外表征及其对哺乳动物细胞的导入作用
Tugce Dastan,Kadir Turan
Tugce Dastan
Purpose: Chitosan has a high potential for transferring DNA molecules into mammalian cells because of its cationic properties. In the present study, we have investigated DNA encapsulation efficiency and loading capacity o...
Simultaneous determination of vitamins C, E and beta-carotene in human plasma by high-performance liquid chromatography with photodiode-array detection [0.03%]
高效液相色谱-光电二极管阵列检测法同时测定人血浆中维生素C、E及β-胡萝卜素
Bin Zhao,Su-Yin Tham,Jia Lu et al.
Bin Zhao et al.
Purpose: To develop a high-performance liquid chromatography (HPLC) method with photodiode-array ultraviolet detection for the simultaneous determination of vitamin C, vitamin E and beta-carotene. ...
A new topological descriptors based model for predicting intestinal epithelial transport of drugs in Caco-2 cell culture [0.03%]
基于拓扑描述符的预测药物在Caco-2细胞培养中肠道上皮转运的新模型
Yovani Marrero Ponce,Miguel A Cabrera Pérez,Vicente Romero Zaldivar et al.
Yovani Marrero Ponce et al.
Purpose: Quantitative Structure-Permeability Relationships (QSPerR) of the intestinal permeability across the (Caco-2) cells monolayer could be obtained by the application of new molecular descriptors. ...
Fluorometric variable-temperature kinetics investigations of the transesterification reaction of procaine with aliphatic alcohols [0.03%]
长链醇与(procain)贝诺扎反应温度动力学的荧光研究
Ali Reza Harifi-Mood,Saeed Haghighi,Mohammad Reza Gholami
Ali Reza Harifi-Mood
Purpose: Variable-Temperature Kinetics has been used to obtain the rate constants of the reaction at various temperatures during one kinetic run. Methods:...
Umma Pathmanathan,David Halgrain,Fouad Chiadmi et al.
Umma Pathmanathan et al.
Purpose: To assess the stability of sulfadiazine (SDZ) oral liquids prepared from tablets and powder at two temperatures. Methods: Solu...
Evaluation of anti-hyperglycemic activity of some novel monocyclic beta lactams [0.03%]
几种新型单环β-内酰胺的抗高血糖活性评价
Rajesh K Goel,Mohinder P Mahajan,Shrinivas K Kulkarni
Rajesh K Goel
Purpose: The present study was undertaken to examine the effect of monocyclic beta-lactams (compounds 5a-5o) for anti-hyperglycemic activity against alloxan-induced diabetes in rats. As these compounds have been shown to ...